Black Turmeric and Aloe Vera in the Management of Oral Submucous Fibrosis: A Prospective Clinical Study

Abstract

Aim: To determine the therapeutic efficacy of Kali haldi in the management of Oral submucous Fibrosis (OSMF) v/s steroid therapy. Materials and Methods: A clinical prospective study was conducted on 42 patients of oral submucous fibrosis were equally divided into 2 groups. Group A patients were treated with a mixture of powdered Kali Haldi and aloe vera gel in equal ratio 3 times a day for 3 months. Group B patients were treated with intralesional injection of hydrocortisone and hyaluronidase for 6 weeks with oral antioxidant supplements for 3 months. Burning sensation, cheek flexibility, mouth opening, and tongue protrusion were evaluated before, during, and after treatment at an interval of 15 days, 1 month, 2, month and 3 months. Results: Statistically significant results were obtained at the end of 3 months duration for both the groups (P < 0.001). The Symptomatic correction was more evident in the case of Group A patients than Group B. Response of the ayurvedic regimen was potentially better as compared to the regular steroid therapy. Conclusion: The study concludes that Combination therapy works wonders in the case of OSMF in stages I, II, III and can be a good option, comparatively safe and with negligible side effects, but potent and equally effective management of oral submucous fibrosis. Henceforth, it will be better to do such kinds of studies on a vast scale including larger samples and longer duration to check the efficacy and durability of this ancient ayurvedic regimen.

Antioxidant treatments in patients with oral submucous fibrosis: A systematic review

“…18,23,24,28 In addition, aloe vera showed better results when compared to curcumin 29 or other antioxidant compounds. 18,24,28 However, if we compare the effects of spirulina with aloe vera, we can conclude that spirulina shows major clinical improvements. 30 Aloe vera contains many antioxidants, including α-tocopherol (vitamin E), carotenoids, ascorbic acid (vitamin C), flavonoids, and tannins.…”

“…All patients treated with aloe vera showed an improvement in the parameters mouth opening, 18,23,24,28–30 burning sensation, 18,23,24,28,29 tongue protrusion 23,24,28 and check flexibility 18,23,24,28 . In addition, aloe vera showed better results when compared to curcumin 29 or other antioxidant compounds 18,24,28 . However, if we compare the effects of spirulina with aloe vera, we can conclude that spirulina shows major clinical improvements 30 .…”

“…A total of 97 articles were obtained from the initial search process: All the studies measured the progression of the OSMF in terms of mouth opening, [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] 17 articles reported on burning sensation, [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] 16 articles discussed tongue protrusion [15][16][17][18]21,26,28,31,33 and 8 articles examined cheek flexibility. 16,18,[21][22]…”

“…All the studies measured the progression of the OSMF in terms of mouth opening, 15–33 17 articles reported on burning sensation, 16–33 16 articles discussed tongue protrusion 15–18,21,26,28,31,33 and 8 articles examined cheek flexibility 16,18,21–24,28,31 . Regarding the type of the study, 17 articles were prospective clinical trials, 15,16,18–25,27–33 1 was a parallel‐group randomized monocentric trial, 17 and 1 was a prospective, randomized, single‐blind study 26 . A total of 1721 patients were treated.…”

“…All patients treated with aloe vera showed an improvement in the parameters mouth opening, 18,23,24,[28][29][30] burning sensation, 18,23,24,28,29 tongue protrusion 23,24,28 and check flexibility. 18,23,24,28 In addition, aloe vera showed better results when compared to curcumin 29 or other antioxidant compounds. 18,24,28 However, if we compare the effects of spirulina with aloe vera, we can conclude that spirulina shows major clinical improvements.…”