Black titania-based theranostic nanoplatform for single NIR laser induced dual-modal imaging-guided PTT/PDT

Mou, Juan; Lin, Tianquan; Huang, Fuqiang; Chen, Hangrong; Shi, Jianlin

doi:10.1016/j.biomaterials.2016.01.009

Cited by 190 publications

(105 citation statements)

References 61 publications

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“…. For example, the recently discovered black titania nanoparticles 27-30 have opened new avenues to broaden their optical absorption from UV to NIR region to some extent, and triggered explosive interests in energy and biological fields. However, attributing to its limited absorption in NIR region, the laser power density generally used for PTT is as high as 2 W cm -2 31, which exceeds the conservative limit ( i.e.…”

Section: Introductionmentioning

confidence: 99%

A New Green Titania with Enhanced NIR Absorption for Mitochondria-Targeted Cancer Therapy

et al. 2017

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A new kind of green titania (G-TiO2-x) with obvious green color was facilely synthesized from black titania (B-TiO2-x) through subsequently strong ultrasonication. Comparatively, this stable G-TiO2-x shows much enhanced near infrared (NIR) absorption, especially around 920 nm, which can be ascribed to the obvious change of TiO2-x lattice order owing to the effect of ultrasonication. This feature enables G-TiO2-x to be stimulated with 980 nm laser in the combined photodynamic therapy (PDT) and photothermal therapy (PTT), which is greatly beneficial for improving tissue penetration depth. Furthermore, since mitochondria are preferred subcellular organelles for PDT/PTT, G-TiO2-x was further designed to conjugate with triphenylphosphonium (TPP) ligand for mitochondria-targeted PDT/PTT to obtain precise cancer treatment. Attributing to the high mitochondria-targeting efficiency and simultaneously synergistic PDT/PTT, high phototherapeutic efficacy and safety with a much lower laser power density (980 nm, 0.72 W cm-2) and low materials dosage were achieved both in vitro and in vivo. In addition, negligible toxicity was found, indicating high biocompatibility. This novel G-TiO2-x could provide new strategies for future precise minimal/non-invasive tumor treatment.

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Section: Introductionmentioning

confidence: 99%

A New Green Titania with Enhanced NIR Absorption for Mitochondria-Targeted Cancer Therapy

et al. 2017

Self Cite

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“…Mou et al. report the development of a black titania (B‐TiO 2− x )‐based nanoagent for single NIR‐light‐triggered PDT and PTT . Prepared B‐TiO 2− x is further functionalized with PEG‐NH 2 to obtain admirable stability and dispersity in various solvents.…”

Section: Cancer Therapy Based On Polymer‐decorated Transition‐metal Nmentioning

confidence: 99%

“…Mou et al report the development of ab lack titania (B-TiO 2Àx )-based nanoagent for single NIR-light-triggered PDT and PTT. [115] PreparedB -TiO 2Àx is furtherf unctionalized with PEG-NH 2 to obtain admirable stabilitya nd dispersity in variouss olvents. Moreover,B -TiO 2Àx has aw ide absorption range in the NIR and UV regions, which provides the possibility to induce the generationo fR OS for PDT and hyperthermia forP TT under irradiation of as ingle l = 808 nm laser (1 Wcm À2 ).…”

Section: Photothermal Andphotodynamic Therapymentioning

confidence: 99%

Recent Advances in Functional‐Polymer‐Decorated Transition‐Metal Nanomaterials for Bioimaging and Cancer Therapy

Zhao

Zhang

et al. 2018

ChemMedChem

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In this review, we focus on recent advances in the synthesis of polymer-functionalized transition-metal-based nanomaterials and follow this up by discussing their applications in bioimaging diagnosis and cancer therapy. Transition-metal-based nanomaterials show great potential in cancer therapy owing to their intensive near-IR absorption, excellent photothermal conversion efficiency, strong X-ray attenuation, and magnetic properties. Functional polymers are usually introduced by a one-step or multistep method to further endow these nanomaterials with great biocompatibility and physiological stability. Polymer-decorated transition-metal nanomaterials show great potential in multimodal imaging diagnosis (photoacoustic imaging, computed tomography, photoluminescence imaging, positron emission tomography, etc.) and cancer therapy (chemotherapy, photothermal therapy, microwave therapy, radiotherapy, photodynamic therapy). At the end of this review, the prospects of these polymer-decorated transition-metal-based nanomaterials are also discussed.

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“…This resulted in a cumulative 15°C temperature rise in the tumor in vivo, which was consistent in 2 days post-injection. [249] They enabled photothermal and PA imaging in vivo with PA signals detectable as early as 5 s after intravenous injection. In another study, superparamagnetic iron oxide (SPION) nanoparticles were functionalized as targeted PTT, NIR fluorescence, and MRI contrast agent.…”

Section: Metal Oxidesmentioning

confidence: 99%

Advanced Near‐Infrared Light‐Responsive Nanomaterials as Therapeutic Platforms for Cancer Therapy

Chien

Chan

Anderson

et al. 2018

Advanced Therapeutics

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Cancer is one of the leading causes of death. Despite the huge progress in the field of cancer drugs and therapies, the treatment outcome is still bleak for most cancer patients. Nanotechnology has revolutionized cancer therapeutics. By using nano-sized particles as delivery systems, therapeutic biomolecules are transported efficiently to the target sites. Moreover, these particles are designed to carry out multiple cancer treatments simultaneously. Near-infrared (NIR) light-responsive nanomaterials have gained much attention as NIR light has a greater penetration depth, minimal phototoxicity, lower autofluorescence, and reduced light scattering. Among the available NIR light-responsive nanomaterials, gold nanorods, upconversion nanoparticles, carbon dots, transition metal dichalcogenide, metal oxides, black phosphorus, and polymeric nanomaterials have become attractive options owing to their excellent optical properties, ease of synthesis and modification, outstanding photodynamic and photothermal conversion properties, and most importantly, favorable toxicity level and biocompatibility which are prerequisites for biological applications. In this review, the outstanding properties, synthesis, and surface functionalization of the aforementioned NIR light-responsive nanomaterials are introduced in detail. Recent advances of these nanomaterials for various cancer treatment modalities are summarized to highlight their versatility and potential in cancer theranostics. Finally, a perspective is proposed on future research directions and their clinical translation.

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Black titania-based theranostic nanoplatform for single NIR laser induced dual-modal imaging-guided PTT/PDT

Cited by 190 publications

References 61 publications

A New Green Titania with Enhanced NIR Absorption for Mitochondria-Targeted Cancer Therapy

A New Green Titania with Enhanced NIR Absorption for Mitochondria-Targeted Cancer Therapy

Recent Advances in Functional‐Polymer‐Decorated Transition‐Metal Nanomaterials for Bioimaging and Cancer Therapy

Advanced Near‐Infrared Light‐Responsive Nanomaterials as Therapeutic Platforms for Cancer Therapy

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