Black tea in chemo-prevention of cancer and other human diseases

Pan, Min; Lai, Ching Shu; Wang, Hong; Lo, Chih Yu; Ho, Chi‐Tang; Li, Shiming

doi:10.1016/j.fshw.2013.03.004

Cited by 73 publications

(64 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1,5 To exert any effects, absorption and biotransformation of chemical ingredients in BTE were taken into account. Some compounds contained in both green tea and black tea, such as catechins, were relatively well established in mammals, including in human.…”

Section: Journal Of Agricultural and Food Chemistrymentioning

confidence: 99%

See 1 more Smart Citation

Black Tea Increased Survival of Caenorhabditis elegans under Stress

Xiong

Huang

et al. 2014

J. Agric. Food Chem.

View full text Add to dashboard Cite

The present study examined the effects of black tea (Camellia sinensis) extracts (BTE) in Caenorhabditis elegans under various abiotic stressors. Results showed BTE increased nematode resistance to osmosis, heat, and UV irradiation treatments. However, BTE could not increase nematodes' lifespan under normal culture conditions and MnCl2-induced toxicity at concentrations we used. Further studies showed that BTE decreased reactive oxygen species and up-regulated some antioxidant enzymes, including GSH-PX, and genes, such as gsh-px and sod-3. However, only a slight extension in mev-1 mutants mean lifespan was observed without significance. These results indicated that the antioxidant activity of BTE might be necessary but not sufficient to protect against aging to C. elegans. Moreover, BTE increased the mRNA level of stress-response genes such as sir-2.1 and sek-1. Our finding demonstrated BTE might increase heat and UV stress resistance in a sir.2.1-dependent manner. Taken together, BTE enhanced stress resistance with multiple mechanisms in C. elegans.

show abstract

Section: Journal Of Agricultural and Food Chemistrymentioning

confidence: 99%

“…1,2 In general, tea is classified into the three following fermentation levels: nonfermented (green tea), semifermented (oolong tea), and fully fermented (black tea). 3 The worldwide consumption of black tea is higher than green tea and oolong tea.…”

Section: ■ Introductionmentioning

confidence: 99%

Black Tea Increased Survival of Caenorhabditis elegans under Stress

Xiong

Huang

et al. 2014

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…Although numerous studies have largely been directed toward the biological properties of GT, currently there are also evidence showing the health benefits of BT. In this sense, Bahorun et al (2012), Fatima and Rizvi (2015), Grassi, Draijer, Desideri, Mulder, and Ferri (2015), Pan et al (2013), Sun et al (2013) and Tang, Li, Liu, Huang, and Ho (2013) indicated the benefits of BT in the prevention of cancer and many inflammatory and metabolic diseases including cardiovascular diseases. Furthermore, the potential health benefits associated with tea consumption have been largely ascribed to the antioxidant capacity of its bioactive molecules (Khan & Mukhtar, 2007;Liu & Huang, 2014).…”

Section: Introductionmentioning

confidence: 99%

Biosorption of green and black tea polyphenols into Saccharomyces cerevisiae improves their bioaccessibility

Jilani

Cilla

Barberá

et al. 2015

Journal of Functional Foods

View full text Add to dashboard Cite

“…20,21 Moreover, a large body of literature is available on the efficacy of flavonoids with regard to chemoprevention and chemotherapy. 20,[22][23][24] High cost, toxic nature and rapid development of resistance have become synonymous with conventional cancer treatment. 25,26 As such, there is an overwhelming need to invest in research that aims to identify new lead compounds that may address these challenges.…”

mentioning

confidence: 99%

Preliminary Screening of Crude Extracts of Fagaropsis Angolensis for Anticancer Activity

Yiaile¹,

Mbaria²,

Ole-Mapenay³

et al. 2018

View full text Add to dashboard Cite

Background: The use of conventional cancer medication is limited by cytotoxicity on normal cells, intolerability of the drugs used and emergence of aggressive tumors which do not respond to treatment. Herbal alternatives are now being touted to be of promising efficacy. Fagaropsis angolensis (FA) has wide ranging ethno medicinal uses in Kenya. However, the anticancer potential of this plant is yet to be fully explored. The present study aims to determine the antiproliferative activity of crude extracts of Fagaropsis angolensis (FA) against African monkey kidney (Vero, E6), throat cancer (Hep2) and colon cancer (CT 26-CL 25) cell lines. Methods: Water and methanol extracts of FA were qualitatively screened to determine their phytochemical composition. In vitro growth inhibition capacity of these extracts on African monkey kidney (Vero, E6), throat cancer (HeP2) and colon cancer (CT-26-CL-25) cell lines was then assessed using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium assay and expressed as 50% inhibitory concentration (IC 50 ). Doxorubicin (standard anticancer agent) was used for comparison. Results: On Vero cell lines, statistical differences (p<0.05) were noted in the IC 50 values of methanol whole root and methanol root stem extracts of FA (5.80+/-0.80μg/ml) against 1.10+/-0.70μg/ml) as well as between Doxorubicin and methanol root stem extracts of FA (6.5+/-3.25 μg/ml against 1.10+/-0.70μg/ml). On colon cancer cell lines, statistical differences (p<0.05) were noted between the IC 50 values of Doxorubicin and the methanol root stem extract of FA (19.00+/-9.00ug/ml against 8.33+/-1.42μg/ml) as well as between Doxorubicin and methanol whole root extract of FA (19.00+/-9.00μg/ml against 5.25+/-0.35μg/ml). The effects of the extracts of FA on throat cancer cell lines were unremarkable. Conclusions: These findings suggest that the choice of solvent may have some effect on the IC 50 values of the extracts on cancer cell lines. It may also be suggested that the methanol root stem and whole root extracts of FA may be sources of important lead molecules that may be useful in the treatment of colon cancer. Conclusion: These findings suggest that the methanol root stem and whole root extracts of FA may be sources of important lead molecules in cancer therapy. 3,4,5 However, therapy induced toxicity on normal body cells, the emergence of aggressive and therapy resistant tumors, as well as low selectivity indices of some chemotherapeutic agents has limited the efficacy of current conventional therapy. 4,6,7 Therefore, there is a need to search for new sources of bioactive compounds that may serve as starting material in the drug development process. Fagaropsis angolensis is a tree that belongs to the Rutacea family.8 In Kenya, the stem bark is used in ethno medical treatment of malaria while the root is chewed as an expectorant.9,10 The antiproliferative activity of this plant is yet to be reported. The present study was conducted to evaluate the antiproliferative activity of Fagaropsis angolens...

show abstract

Black tea in chemo-prevention of cancer and other human diseases

Cited by 73 publications

References 96 publications

Black Tea Increased Survival of Caenorhabditis elegans under Stress

Black Tea Increased Survival of Caenorhabditis elegans under Stress

Biosorption of green and black tea polyphenols into Saccharomyces cerevisiae improves their bioaccessibility

Preliminary Screening of Crude Extracts of Fagaropsis Angolensis for Anticancer Activity

Contact Info

Product

Resources

About