Black Tea Improves Endothelial Function in Renal Transplant Recipients

Ardalan, Mohammadreza; Tarzamni, Mohammad Kazem; Shoja, Mohammadali Mohajel; Tubbs, R. Shane; Rahimi-Ardabili, Babak; Ghabili, Kamyar; Khosroshahi, Hamid T.

doi:10.1016/j.transproceed.2007.04.010

Cited by 35 publications

(27 citation statements)

References 19 publications

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“…In a randomized controlled parallel study, Hodgson et al [96] showed a significant and consistent increase in endothelium-dependent vasodilation after 4 week regular consumption of 5 cups/d of black tea in dyslipidemic subjects. Of interest, Ardalan et al [97] observed that shortterm consumption of black tea significantly increased FMD (P < 0.05) in renal transplant recipients, while Hodgson et al [98] showed no significant acute effects of black tea on endothelial function. Although the majority of available data supports the evidence that flavonoid-rich foods and beverages are able to improve NO bioavailability and thereby increase endothelium-dependent vasorelaxation in healthy subjects as well as in various pathological conditions a recent meta-analisys [88] that sought to systematically review the effectiveness of different flavonoid subclasses and flavonoid-rich food sources on CVD and risk factors including hundred thirty-three trials, reported no significant chronic effects from red wine or grape and other flavanols, while the data suggested a beneficial effect of black tea and chocolate or cocoa [black tea improved FMD by 3.40% (95% CI:…”

Section: Flavanols Endothelium and Athero-sclerosis: Vascular Healthmentioning

confidence: 99%

Flavonoids, Vascular Function and Cardiovascular Protection

Grassi¹,

Desideri²,

Croce³

et al. 2009

CPD

170

179

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A large body of evidence supports that the dietary intake of polyphenols - particularly of flavonoids and the specific class of flavonoids named flavanols - might be able to exert some beneficial vascular effects and reduce the risk for cardiovascular morbidity and mortality. The review of epidemiological and mechanistic studies supports the role of flavonoids, particularly cocoa and tea flavanols, in protecting the cardiovascular system against cardiovascular disease. Nevertheless, flavonoids are an heterogeneous group of natural molecules differently represented in fruit and vegetables and definitive data on cardiovascular benefits are lacking. The weakness of the available data include few and very small studies, no crossover designed studies and a wide range of dose and type of flavonoids tested. Thus, although flavonoid-rich foods and beverages are likely to protect cardiovascular system, further research is needed to characterize the mechanism of action on flavanol-rich foods. Long-term clinical trials are also needed to definitively clarify the benefits deriving from long-term consumption of flavanol-rich foods, particularly focussing on the lowest effective levels as well as synergism or antagonistic actions between different classes of flavonoids commonly found in foods.

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Section: Flavanols Endothelium and Athero-sclerosis: Vascular Healthmentioning

confidence: 99%

Flavonoids, Vascular Function and Cardiovascular Protection

Grassi¹,

Desideri²,

Croce³

et al. 2009

CPD

170

179

View full text Add to dashboard Cite

show abstract

“…Endothelial dysfunction is common in renal transplant recipients. A recent study demonstrates that short-term consumption of black tea improves endothelium-dependent vasodilatation in renal transplant recipients (Ardalan et al, 2007).…”

Section: Protective Effect Against Endothelial Dysfunctionmentioning

confidence: 99%

Tea polyphenols benefit vascular function

et al. 2008

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Tea, the most popular beverage worldwide, is consumed in three basic forms; green tea, black tea and oolong tea. Tea contains over 4,000 chemicals some of which are bioactive. In recent years there has been a mounting interest in understanding the cardiovascular and metabolic benefits of polyphenolic flavonoids in tea, which can be used as a supplement among patients. Diverse cardioprotective effects of consuming tea or tea polyphenols have been described on pathological conditions, e. g. hypertension, atherosclerosis, diabetics, hypercholesterolemia, obesity, and are attributed to antioxidative, anti-thrombogenic, anti-inflammatory, hypotensive and hypocholesterolemic properties of tea polyphenols. This review focuses on cardiovascular benefits of tea polyphenols based on in vitro and in vivo studies on experimental animal models and on studies of human subjects in four areas: (1) vasorelaxant effect; (2) protective effect against endothelial dysfunction; (3) antioxidant effect and (4) hypolipidemic effect. We will briefly discuss the effects of tea on atherosclerosis and hypertension.

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“…These derangements develop early in the course of CKD, and in conjunction with traditional risk factors (age, hypertension, diabetes mellitus, hypercholesterolemia, smoking, etc.) further contribute to the development and progression of vascular calcification and atherosclerosis [3-5]. …”

Section: Introductionmentioning

confidence: 99%

The Relationship between Carotid and Femoral Artery Intima-Media Thickness and Histopathologic Grade of Atherosclerosis in Patients with Chronic Kidney Disease

Nezami

Ghabili

Shokouhi-Gogani

et al. 2018

Nephron

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Background/Aims: Variability in the grade of atherosclerosis among patients with chronic kidney disease (CKD) could affect the ultrasound measurements of intima media thickness (IMT). We sought to investigate IMTs of carotid (cIMT) and femoral (fIMT) arteries in CKD patients and assess the degree of their correlation with histopathological atherosclerosis. Methods: Eighty-nine out of 99 enrolled subjects completed this study. The subjects were divided into 3 groups: 34 patients with CKD (Case group), 31 with coronary artery disease undergoing coronary artery bypass graft (CABG, positive control group), and 24 healthy kidney donors (negative control group). For histopathological assessment of atherosclerosis, arterial tissue samples were obtained from the patients in each study group. The cIMT and fIMTs were measured by ultrasonography. Results: Histopathological atherosclerosis was present in 82.3, 100, and 20.8% of CKD, CABG, and donor groups respectively (p < 0.001). CKD patients had higher values of cIMT and fIMT than the donor group (p = 0.01 and 0.004, respectively). cIMT was positively correlated with the grade of atherosclerosis in the CKD group only (p < 0.001), while fIMT was correlated with the grade of atherosclerosis in both CKD and donor groups (p < 0.001 and p = 0.009 respectively). In CKD patients, cIMT >0.65 mm and femoral values >0.57 mm predicted the presence of histopathological atherosclerosis with sensitivities of 96 and 92% respectively. Conclusion: Higher values of cIMT and fIMT in CKD patients are associated with higher rates and degrees of histopathological atherosclerosis. Additionally, when compared to fIMT, cIMT has a higher sensitivity for detecting atherosclerosis in CKD patients.

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Black Tea Improves Endothelial Function in Renal Transplant Recipients

Cited by 35 publications

References 19 publications

Flavonoids, Vascular Function and Cardiovascular Protection

Flavonoids, Vascular Function and Cardiovascular Protection

Tea polyphenols benefit vascular function

The Relationship between Carotid and Femoral Artery Intima-Media Thickness and Histopathologic Grade of Atherosclerosis in Patients with Chronic Kidney Disease

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