Black tea consumption and cancer risk: A prospective study

Heilbrun, Lance K.; Nomura, Abraham M. Y.; Stemmermann, Grant N.

doi:10.1038/bjc.1986.226

Cited by 133 publications

(51 citation statements)

References 25 publications

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“…Epidemiological studies, although not conclusive, have suggested the protective role of green tea against CaP development (10)(11)(12)(13)(14). Recent laboratory studies have indicated that green tea and its polyphenolic constituents impart inhibitory effects on the activities of many enzymatic, metabolic, and signaling pathways that have relevance to cancer development and progression (31)(32)(33)(34)(35)(36).…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiological studies, although inconclusive, suggest a protective effect of tea consumption on some cancer types in humans (11,12). Limited epidemiological studies indicate that people who consume tea regularly may have a lower risk of CaP (13,14). Further, the Japanese and Chinese populations who regularly consume tea, especially green tea, have one of the lowest incidences of CaP in the world (15,16).…”

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confidence: 99%

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Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols

Gupta

Hastak

Ahmad

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

450

368

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Development of effective chemopreventive agents against prostate cancer (CaP) for humans requires conclusive evidence of their efficacy in animal models that closely emulates human disease. The autochthonous transgenic adenocarcinoma of the mouse prostate (TRAMP) model, which spontaneously develops metastatic CaP, is one such model that mimics progressive forms of human disease. Employing male TRAMP mice, we show that oral infusion of a polyphenolic fraction isolated from green tea (GTP) at a human achievable dose (equivalent to six cups of green tea per day) significantly inhibits CaP development and increases survival in these mice. In two separate experiments, the cumulative incidence of palpable tumors at 32 weeks of age in 20 untreated mice was 100% ( prostate cancer ͉ chemoprevention ͉ apoptosis

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols

Gupta

Hastak

Ahmad

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

450

368

View full text Add to dashboard Cite

show abstract

“…Epidemiological studies, though not conclusive, have suggested the protective role of green tea against CaP development (10)(11)(12)(13)(14). Recent laboratory studies have indicated that green tea and its polyphenolic constituents impart inhibitory effects on the activities of many enzymatic, metabolic and signaling pathways that have relevance to cancer development and progression (31)(32)(33)(34)(35)(36).…”

Section: Discussionmentioning

confidence: 99%

“…Since prostate cancer is typically diagnosed in men aged 50 years and older, even a slight delay in the onset and subsequent progression of the disease through the use of chemopreventive agent(s) could have important health benefits (2)(3)(4)(5) Epidemiological studies, though inconclusive, have suggested the protective role of green tea against prostate cancer development (6,7). Recent laboratory studies have indicated that green tea and its polyphenolic constituents impart inhibitory effects on the activities of many enrymatic, metabolic and signaling pathways that have relevance to cancer development and progression (8)(9)(10)(11)(12)(13). A number of studies have shown the growth inhibitory effects of green tea against many animal tumor bioassay systems including lung, skin and forestomach (14)(15)(16).…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiological studies, though inconclusive, suggest a protective effect of tea consumption on some cancer types in humans (11,12). Limited epidemiological studies indicate that people who consume tea regularly may have a lower risk of CaP (13,14). Further, the Japanese and Chinese populations who regularly consume tea, especially green tea, have one of the lowest incidences of CaP in the world (15,16).…”

Section: Introductionmentioning

confidence: 99%

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Green Tea in Prevention and Therapy of Prostate Cancer

Mukhtar¹

2001

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REPORT DOCUMENTATION PAGEForm Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302 and to the Office of Management and Budget, Paperwork Reduction Project (0704-0188), Washington, DC 20S03

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Green tea consumption and the risk of pancreatic and colorectal cancers

et al. 1997

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The effect of green tea drinking in reducing human cancer risk is unclear, though a protective effect has been reported in numerous animal studies and several epidemiologic investigations. Herein the hypothesis that green tea consumption may reduce the risk of cancers of the colon, rectum and pancreas is examined in a large population-based case-control study conducted in Shanghai, China. Newly diagnosed cancer cases (931 colon, 884 rectum and 451 pancreas) during 1990-1993 among residents 30-74 years of age were included. Controls (n 5 1,552) were selected among Shanghai residents and frequency-matched to cases by gender and age. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) of each cancer associated with green tea consumption were derived after adjustment for age, income, education and cigarette smoking. Additional adjustment for dietary items and body size was found to have minimal impact. An inverse association with each cancer was observed with increasing amount of green tea consumption, with the strongest trends for rectal and pancreatic cancers. r 1997 Wiley-Liss, Inc.* Tea preparations and tea polyphenols have been shown to inhibit formation and growth of a variety of solid tumors in laboratory rats and mice (Katiyar et al., 1993;Yang and Wang, 1993;Han, 1993;Narisawa and Fukaura, 1993;Mukhtar et al., 1994;Yin et al., 1994;Wang et al., 1994;Hirose et al., 1994;Bu-Abbas et al., 1995). Evidence for a protective effect of tea drinking on human cancers, however, has been inconclusive (IARC, 1991), though a reduced risk of gastrointestinal cancers has been suggested among green tea drinkers in several epidemiologic studies (Kono et al., 1988;Kato et al., 1990;Gao et al., 1994;Yu et al., 1995;Ji et al., 1996). Since green tea is one of the most commonly consumed beverages among Chinese adults, the wide range of intake levels provides a special opportunity to assess the association between green tea drinking and cancer risks. Herein we examine the association between green tea drinking and the risk of cancers of the colon, rectum and pancreas. MATERIAL AND METHODSThe methods for the study have been described in detail elsewhere (Ji et al., 1995). Briefly, cases were permanent Shanghai residents newly diagnosed with cancers of the colon, rectum or pancreas at ages 30-74 between October 1990 and June 1993, identified through the Shanghai Cancer Registry. A standardized medical abstract was used to collect information on date, method and outcome of diagnosis. Controls were selected randomly from files of permanent residents of Shanghai and frequency-matched to cases by age (5-year categories) and sex.Study subjects were interviewed in person by trained interviewers using a standardized questionnaire to elicit information on demographic and residential characteristics; dietary practices; consumption of cigarettes, alcohol and tea; height and weight; medical history; family cancer history; occupation; and physical activity. Information on tea consumption included regular tea drinking status (defi...

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Black tea consumption and cancer risk: A prospective study

Cited by 133 publications

References 25 publications

Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols

Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols

Green Tea in Prevention and Therapy of Prostate Cancer

Green tea consumption and the risk of pancreatic and colorectal cancers

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