Black Tea and Theaflavins Assist Healing of Indomethacin-Induced Gastric Ulceration in Mice by Antioxidative Action

Adhikary, Biplab; Yadav, Sudhir Kumar; Roy, K.N.; Bandyopadhyay, Sandip K.; Chattopadhyay, Subrata

doi:10.1155/2011/546560

Cited by 71 publications

(53 citation statements)

References 41 publications

(47 reference statements)

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“…Moreover, [19] suggested that, NSAIDs-induced impairment of the tight junction complex morphology and permeability between viable gastric mucosal epithelial cells may be a major contributing factor in the etiology of stomach disorder. The zymogenic granules of chief cell has a central deeper part with pale periphery, this was similar to the results of [20].…”

Section: Discussionsupporting

confidence: 87%

Protective Effect of Ascorbic Acid and Ranitidine on the Indomethacin Induced Gastric Injury in Adult Albino Rats; Light and Electron Microscopy

Shalaby¹

2016

IJCDA

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Abstract:Indomethacin is a non-steroidal anti-inflammatory drug, used in the treatment of many inflammatory diseases.The major side effect limiting its clinical use is the gastric damages. The aim of this work was to study the possible protective effects of vitamin c and ranitidine on the gastric lesion induced by indomethacin in adult albino rats. Forty adult albino rats were divided into five equal groups: The control group, indomethacin group, indomethacin plus vitamin c, indomethacin plus ranitidine, and indomethacin plus both vitamin c and ranitidine. In the control group, the rats received normal daily diet for 10 days. In the indomethacin group, the rats were treated with indomethacin for 10 consecutive days. In indomethacin plus vitamin c group, the rats were treated with indomethacin as the second group, in addition to vitamin c, 5 minutes prior to the indomethacin for 10 days. In the fourth group, the rats were treated with indomethacin as the second group, and then received ranitidine 5 min prior to the indomethacin, for 10 consecutive days. The last group received the indomethacin as the second group, and then received vitamin c and ranitidine, 5 min prior to the indomethacin, daily for 10 days. After 10 days from the treatment, all the rats were anaesthetized, and the specimens of the stomach were prepared for light and electron microscopies. Indomethacin produced erosions and ulcerations of the gastric mucosa. There are focal areas of degeneration and inflammatory cell infiltration in the lamina propria, the gastric gland cells showed vacuolations, degeneration and disappearance of their nuclei. It also induced dilatation and congestion of the blood capillaries in the submucosa of the stomach, also the surface mucin layer was decreased in its thickness. Electron microscopic examination showed that: Indomethacin induced degeneration and vacuolations of the gastric gland cells, with degeneration of their mitochondria and nuclei. Chief cells showed abnormalities in their zymogenic granules which appeared with dark central part and pale periphery. Administration of vitamin c and ranitidine prior to the indomethacin intake reduced the pathogenic changes of the gastric wall, with slight return to the picture of the control group.

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Section: Discussionsupporting

confidence: 87%

Protective Effect of Ascorbic Acid and Ranitidine on the Indomethacin Induced Gastric Injury in Adult Albino Rats; Light and Electron Microscopy

Shalaby¹

2016

IJCDA

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“…TF healed indomethacin induced gastric ulcer by its antioxidative properties, synthesis of PGE2 and enhancement of mucin secretion. TF also helps to suppress various inflammatory modulators in ulcer margin [53]. eNOS modulation may be another possible pathway of gastric ulcer healing by TF [53].…”

Section: Camellia Sinensismentioning

confidence: 99%

“…TF also helps to suppress various inflammatory modulators in ulcer margin [53]. eNOS modulation may be another possible pathway of gastric ulcer healing by TF [53].…”

Section: Camellia Sinensismentioning

confidence: 99%

Herbal Remedy: An Alternate Therapy of Nonsteroidal Anti-Inflammatory Drug Induced Gastric Ulcer Healing

Chatterjee

Bandyopadhyay

2014

Ulcers

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Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used therapeutic drug groups used worldwide for curing an array of health problems like pain, inflammation, cardiovascular complications, and many other diseases, but they may cause different side effects including gastroduodenal disorders. So, there is a growing interest and need to search for nontoxic, antiulcer formulations from medicinal plants to treat NSAIDs induced gastric ulcer. Extensive research has reported on many natural plants like Camellia sinensis, Phyllanthus emblica, Myristica malabarica, Piper betle, Picrorhiza kurroa, and so forth, and their active constituents reduced NSAIDs induced gastric ulcer via their antioxidative as well as immunomodulatory activity. Therefore, use of herbal formulations in daily life may prevent NSAIDs induced gastric ulceration and other side effects.

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“…PGs stimulate the secretion of bicarbonates and mucus, promote ulcer healing and inhibit the secretion of gastric acid. PGE 2 , one of the major PGs of the gastric mucosa, can inhibit the secretion of gastric acid (41). The ethanol-induced depletion of gastric mucus has been described previously (42), and this may be caused by an inhibitory effect on the gastric production of PGE 2 (43).…”

Section: Discussionmentioning

confidence: 95%

Syzygium aromaticum water extract attenuates ethanol-induced gastric injury through antioxidant effects in rats

Jin

Lee

Shin

et al. 2016

Molecular Medicine Reports

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Abstract. The aim of the present study was to investigate whether Syzygium aromaticum water extract (SAWE) has a protective effect against ethanol-induced gastric injury in rats. Acute gastric injury was induced via intragastric administration of absolute ethanol at a dose of 5 ml/kg. SAWE (250 or 500 mg/kg/day) or cimetidine (100 mg/kg/day), which was used as a positive control, were administered to the rats 2 h prior to ethanol administration for 3 days. All rats were sacrificed 24 h following the final ethanol administration. To examine whether SAWE has a gastroprotective effect, assays were performed to assess the contents of malondialdehyde (MDA) and glutathione (GSH), the activities of catalase, glutathione-S-transferase and superoxide dismutase, and an immune-linked immunosorbent assay was performed for prostaglandin E 2 (PGE 2 ) production in gastric tissues by hematoxylin and eosin and periodic acid-Schiff staining. Histological assessment of the gastric wall was performed. Compared with ethanol treatment alone, treatment with SAWE at a dose of 250 mg/kg/day significantly decreased the gastric MDA content and increased the GSH content, catalase activity, and production of gastric PGE 2 . Histological assessment showed that SAWE attenuated inflammatory cell infiltration and the loss of epithelial cells. These findings suggested that SAWE protected against ethanol-induced gastric mucosal injury in the rats. These effects appeared to be associated with antioxidant activity, activation of the production of PGE 2 , suppression of inflammatory cell infiltration and loss of epithelial cells in the gastric mucosa. Collectively, SAWE may be beneficial in the prevention of gastric disease associated to oxidative stress.

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Black Tea and Theaflavins Assist Healing of Indomethacin-Induced Gastric Ulceration in Mice by Antioxidative Action

Cited by 71 publications

References 41 publications

Protective Effect of Ascorbic Acid and Ranitidine on the Indomethacin Induced Gastric Injury in Adult Albino Rats; Light and Electron Microscopy

Protective Effect of Ascorbic Acid and Ranitidine on the Indomethacin Induced Gastric Injury in Adult Albino Rats; Light and Electron Microscopy

Herbal Remedy: An Alternate Therapy of Nonsteroidal Anti-Inflammatory Drug Induced Gastric Ulcer Healing

Syzygium aromaticum water extract attenuates ethanol-induced gastric injury through antioxidant effects in rats

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