Black Rice (<i>Oryza sativa L</i>., Poaceae) Extract Reduces Hippocampal Neuronal Cell Death Induced by Transient Global Cerebral Ischemia in Mice

Hwang, Sun Nyoung; Kim, Jae Cheon; Bhuiyan, Mohammad Iqbal Hossain; Kim, Joo Youn; Yang, Ji Seon; Yoon, Shin Hee; Yoon, Kee Dong; Kim, Seong Yun

doi:10.5607/en.2018.27.2.129

Cited by 9 publications

(4 citation statements)

References 35 publications

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“…The primary explanation for the impact is that anthocyanin, phenolic, and flavonoid compounds have the capacity to function as hydrogen donors and reducing agents, neutralizing ROS, and removing superoxide and hydrogen peroxide ions. Numerous studies have found that HN rice bran has two main functions in lowering oxidative stress through ( 1 ) direct interaction with ROS and ( 2 ) augmentation of antioxidant enzyme activity ( 56 57 58 59 60 ).…”

Section: Discussionmentioning

confidence: 99%

The protective effect of Thai rice bran on N-acetyl-ρ-aminophen-induced hepatotoxicity in mice

Wanyo,

So-In

2024

Research in Pharmaceutical Sciences

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Background and purpose: N-acetyl-ρ-aminophen (APAP) is a widely used medication with analgesic and antipyretic characteristics. High paracetamol doses can damage the liver. Thai-pigmented rice may treat numerous liver disorders due to its antioxidant, anti-inflammatory, and glutathione-restoring capabilities. This study aimed to evaluate the phenolic components in three Thai rice bran extracts and their antioxidant and hepatoprotective activities in an animal model. Experimental approach: Fifty male mice were randomly assigned to the control and APAP studies. Each study was divided into 5 groups (n = 5) treated with distilled water, Hom Mali, Hang-Ngok, and Hom Nil (HN) rice compared with N-acetylcysteine with/without 60 mg/kg/day of APAP orally once a day for two weeks. Blood and liver sampling were collected for analysis. Findings/Results: HN rice bran exhibited higher contents of total phenolic, total flavonoid, total anthocyanin, ferric-reducing antioxidant, and 1,1-diphenyl-2-picrylhydrazyl radical scavenging activities than Hom Mali and Hang-Ngok. Anthocyanin was merely detected in HN. Following APAP administration, mice exhibited significant increases in hepatic enzymes including alanine aminotransferase (ALT) and aspartate aminotransferase (AST), pro-inflammatory cytokines (tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6)), and malondialdehyde (MDA), but lower levels of antioxidant enzymes and glutathione profiles. Amongst the three cultivars, HN rice was the only compound that decreased MDA, ALT, AST, TNF-α, and IL-6 while increasing antioxidant enzyme activity such as superoxide dismutase, catalase, and glutathione peroxidase that was very close to that of N-acetylcysteine groups. Conclusion and implications: Given the hepatoprotective and antioxidant properties, HN has the potential to be used as a health supplement.

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Section: Discussionmentioning

confidence: 99%

The protective effect of Thai rice bran on N-acetyl-ρ-aminophen-induced hepatotoxicity in mice

Wanyo,

So-In

2024

Research in Pharmaceutical Sciences

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“…However, most studies have failed due to toxicity and side effects [ 17 ]. Medicinal plants have been studied as alternative preventive or therapeutic agents in various diseases including brain ischemia because of their minimal toxic effects [ 31 , 50 , 51 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

Gynura procumbens Root Extract Ameliorates Ischemia-Induced Neuronal Damage in the Hippocampal CA1 Region by Reducing Neuroinflammation

et al. 2021

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Gynura procumbens has been used in Southeast Asia for the treatment of hypertension, hyperglycemia, and skin problems induced by ultraviolet irradiation. Although considerable studies have reported the biological properties of Gynura procumbens root extract (GPE-R), there are no studies on the effects of GPE-R in brain damages, for example following brain ischemia. In the present study, we screened the neuroprotective effects of GPE-R against ischemic damage and neuroinflammation in the hippocampus based on behavioral, morphological, and biological approaches. Gerbils received oral administration of GPE-R (30 and 300 mg/kg) every day for three weeks and 2 h after the last administration, ischemic surgery was done by occlusion of both common carotid arteries for 5 min. Administration of 300 mg/kg GPE-R significantly reduced ischemia-induced locomotor hyperactivity 1 day after ischemia. Significantly more NeuN-positive neurons were observed in the hippocampal CA1 regions of 300 mg/kg GPE-R-treated animals compared to those in the vehicle-treated group 4 days after ischemia. Administration of GPE-R significantly reduced levels of pro-inflammatory cytokines such as interleukin-1β, -6, and tumor necrosis factor-α 6 h after ischemia/reperfusion. In addition, activated microglia were significantly decreased in the 300 mg/kg GPE-R-treated group four days after ischemia/reperfusion compared to the vehicle-treated group. These results suggest that GPE-R may be one of the possible agents to protect neurons from ischemic damage by reducing inflammatory responses.

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“…Similarly, cyanidin 3-O-β-glucopyranoside has a neuroprotective effect in an animal cerebral artery occlusion model [151]. In mice under conditions of transient global ischemia, anthocyanins from black rice (Oryza sativa L., Poaceae) attenuate neuronal cell death, inhibit reactive astrogliosis, and prevent loss of expression of glutathione peroxidase in the hippocampus, significantly improving memory impairment [152].…”

Section: Hypoxia/cerebral Ischemiamentioning

confidence: 99%

Anthocyanins: Molecular Aspects on Their Neuroprotective Activity

Zaa,

Marcelo,

et al. 2023

Biomolecules

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Anthocyanins are a type of flavonoids that give plants and fruits their vibrant colors. They are known for their potent antioxidant properties and have been linked to various health benefits. Upon consumption, anthocyanins are quickly absorbed and can penetrate the blood–brain barrier (BBB). Research based on population studies suggests that including anthocyanin-rich sources in the diet lower the risk of neurodegenerative diseases. Anthocyanins exhibit neuroprotective effects that could potentially alleviate symptoms associated with such diseases. In this review, we compiled and discussed a large body of evidence supporting the neuroprotective role of anthocyanins. Our examination encompasses human studies, animal models, and cell cultures. We delve into the connection between anthocyanin bioactivities and the mechanisms underlying neurodegeneration. Our findings highlight how anthocyanins’ antioxidant, anti-inflammatory, and anti-apoptotic properties contribute to their neuroprotective effects. These effects are particularly relevant to key signaling pathways implicated in the development of Alzheimer’s and Parkinson’s diseases. In conclusion, the outcome of this review suggests that integrating anthocyanin-rich foods into human diets could potentially serve as a therapeutic approach for neurological conditions, and we identify promising avenues for further exploration in this area.

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Black Rice (Oryza sativa L., Poaceae) Extract Reduces Hippocampal Neuronal Cell Death Induced by Transient Global Cerebral Ischemia in Mice

Cited by 9 publications

References 35 publications

The protective effect of Thai rice bran on N-acetyl-ρ-aminophen-induced hepatotoxicity in mice

The protective effect of Thai rice bran on N-acetyl-ρ-aminophen-induced hepatotoxicity in mice

Gynura procumbens Root Extract Ameliorates Ischemia-Induced Neuronal Damage in the Hippocampal CA1 Region by Reducing Neuroinflammation

Anthocyanins: Molecular Aspects on Their Neuroprotective Activity

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