Black phosphorus nanosheets enhance differentiation of neural progenitor cells for improved treatment in spinal cord injury

He, Fumei; Cheng, Ke; Qi, Jiaxin; He, F.; Chu, Chengjun; Zhao, Jun; Ding, Jun; Kong, FanShu; Cao, ZiMeng; Liu, Gan; Deng, Wenbin

doi:10.1016/j.cej.2023.144977

Cited by 6 publications

(3 citation statements)

References 41 publications

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“…In the literature, some studies using various hydrogels and nanoparticles after SCI have shown that inflammation/glial scar tissue formation was reduced and significant functional gains and neural regeneration were achieved. [99][100][101][102][103][104][105] The ideal scaffold for neural regeneration must provide a 3D interconnected porous structure and suitable physicochemical properties, such as mechanical strength, elasticity, stiffness, hydrophilicity, and surface conductivity. The designed scaffold should display an ideal biocompatibility profile and suitable degradation rate over time.…”

Section: Discussionmentioning

confidence: 99%

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Development of BDNF/NGF/IKVAV Peptide Modified and Gold Nanoparticle Conductive PCL/PLGA Nerve Guidance Conduit for Regeneration of the Rat Spinal Cord Injury

Ozcicek,

Aysit,

Balcikanli

et al. 2024

Macromolecular Bioscience

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Spinal cord injuries are very common worldwide, leading to permanent nerve function loss with devastating effects in the affected patients. The challenges and inadequate results in the current clinical treatments are leading scientists to innovative neural regenerative research. Advances in nanoscience and neural tissue engineering have opened new avenues for SCI treatment. In order for designed nerve guidance conduit to be functionally useful, it must have ideal scaffold properties and topographic features that promote the linear orientation of damaged axons. In this study, we aimed to develop channeled polycaprolactone (PCL)/Poly‐D,L‐lactic‐co‐glycolic acid (PLGA) hybrid film scaffolds, modify their surfaces by IKVAV pentapeptide/gold nanoparticles (AuNPs) or polypyrrole (PPy) and investigate the behavior of motor neurons on the designed scaffold surfaces in vitro under static/bioreactor conditions. We also examined their potential to promote neural regeneration after implantation into the rat spinal cord injury by shaping the film scaffolds modified with neural factors into a tubular form. We show that channeled groups decorated with AuNPs highly promote neurite orientation under bioreactor conditions and also the developed optimal nerve guidance conduit (PCL/PLGA G1‐IKVAV/BDNF/NGF‐AuNP50) highly regenerates spinal cord injury. The results indicated that the designed scaffold could be an ideal candidate for spinal cord regeneration.This article is protected by copyright. All rights reserved

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Development of BDNF/NGF/IKVAV Peptide Modified and Gold Nanoparticle Conductive PCL/PLGA Nerve Guidance Conduit for Regeneration of the Rat Spinal Cord Injury

Ozcicek,

Aysit,

Balcikanli

et al. 2024

Macromolecular Bioscience

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show abstract

“…Moreover, when employed as a blank nanocarrier in stem cell therapy, BP demonstrates promising therapeutic outcomes. In the future, the assembly of BP with gene carriers, growth factors, and small molecule drugs holds the potential to become a powerful tool for improving stem cell survival and inducing neuronal differentiation, thereby offering novel insights into the treatment of neurological disorders [ 52 ].…”

Section: The Physicochemical Properties and Biological Effects Of Bla...mentioning

confidence: 99%

Advances in the Application of Black Phosphorus-Based Composite Biomedical Materials in the Field of Tissue Engineering

Qi,

Zhang,

Wang

et al. 2024

Pharmaceuticals

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Black Phosphorus (BP) is a new semiconductor material with excellent biocompatibility, degradability, and optical and electrophysical properties. A growing number of studies show that BP has high potential applications in the biomedical field. This article aims to systematically review the research progress of BP composite medical materials in the field of tissue engineering, mining BP in bone regeneration, skin repair, nerve repair, inflammation, treatment methods, and the application mechanism. Furthermore, the paper discusses the shortcomings and future recommendations related to the development of BP. These shortcomings include stability, photothermal conversion capacity, preparation process, and other related issues. However, despite these challenges, the utilization of BP-based medical materials holds immense promise in revolutionizing the field of tissue repair.

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Biomimetic multi-channel nerve conduits with micro/nanostructures for rapid nerve repair

Wang,

Chen,

Chen

et al. 2024

Bioactive Materials

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Black phosphorus nanosheets enhance differentiation of neural progenitor cells for improved treatment in spinal cord injury

Cited by 6 publications

References 41 publications

Development of BDNF/NGF/IKVAV Peptide Modified and Gold Nanoparticle Conductive PCL/PLGA Nerve Guidance Conduit for Regeneration of the Rat Spinal Cord Injury

Development of BDNF/NGF/IKVAV Peptide Modified and Gold Nanoparticle Conductive PCL/PLGA Nerve Guidance Conduit for Regeneration of the Rat Spinal Cord Injury

Advances in the Application of Black Phosphorus-Based Composite Biomedical Materials in the Field of Tissue Engineering

Biomimetic multi-channel nerve conduits with micro/nanostructures for rapid nerve repair

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