Black Phosphorus: Bioactive Nanomaterials with Inherent and Selective Chemotherapeutic Effects

Zhou, Wenhua; Pan, Ting; Cui, Haodong; Zhi-qiang, Zhao; Chu, Paul K.; Yu, Xue‐Feng

doi:10.1002/anie.201810878

Cited by 125 publications

(141 citation statements)

References 52 publications

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“…Notably, several nanomaterials, such as nanodiamonds and titania‐coated gold nanoparticles, have been demonstrated to be capable of inhibiting autophagy via multiple pathways. A recent report indicates that black phosphorus (BP) nanosheets, which have been explored as robust biodegradable therapeutic platforms in various biomedical settings, could block autophagy flux and aggravate aberrant autophagosomes accumulation . The fast degradation of BP nanosheets in cancer cells as a consequence of intensified reactive oxygen species (ROS) production, promotes the acute elevation of intracellular phosphate anions (PO 4 3− ).…”

Section: Methodsmentioning

confidence: 99%

“…Either elevating 2DG concentrations or prolonging 2DG incubation durations could further aggravate the blockage of lactate production (maximum 77.6% inhibition). Comparatively, BP nanosheets alone failed to elicit distinct inhibitory effect, although at a high BP concentration (64 ppm) the production of lactate from HeLa cells decreased slightly (16.79%), which may result from the intrinsic cytotoxicity of BP . These results demonstrate that 2DG is efficient in restraining glycolysis, while BP nanosheets have minor (or even negligible at low concentrations) antiglycolytic effect.…”

Section: Methodsmentioning

confidence: 99%

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Augmenting Tumor‐Starvation Therapy by Cancer Cell Autophagy Inhibition

et al. 2020

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It was recently recognized that cancer therapeutic efficacy may be greatly compromised by an intrinsic protective mechanism called autophagy, by which cancer cells survive in harsh conditions such as starvation. Here, a synergetic strategy is described for cancer treatment by suppressing such a protective mechanism for augmenting tumor‐starvation therapy. The synergetic therapy is achieved by restraining glucose metabolism using an antiglycolytic agent to predispose cancer cells to severe energy deprivation; concurrently the downstream autophagic flux and compensatory energy supplies are blocked by the autophagy inhibitor black phosphorus nanosheet. Cancer cells fail to extract their own nutrient to feed themselves, finally succumbing to therapeutic interventions and starving to death. Both in vitro and in vivo results evidence the cooperative effect between the autophagy inhibitor and antiglycolytic agent, which leads to remarkable synergetic antineoplastic outcome. It is expected that such a combinational approach by concurrently blocking exogenous and endogenous nutrition supplies will be beneficial to the design of effective tumor‐specific cancer therapies in the future.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Augmenting Tumor‐Starvation Therapy by Cancer Cell Autophagy Inhibition

et al. 2020

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“…Mono‐elemental 2D materials such as phosphorene, antimonene, and borophene are particularly promising because of their extraordinary physicochemical properties and outstanding biocompatibility; their electronic and optical properties have resulted in them being regarded as promising anticancer therapeutics . Yu and co‐workers reported that 2D phosphorene could induce significant arrest of the G2/M phase in cancer cells, leading to targeted apoptotic and autophagic cell death with great selectivity . Antimonene‐based photonic drug‐delivery platforms initiated the application of 2D antimonene nanomaterials in cancer theranostics .…”

Section: Introductionmentioning

confidence: 99%

Arsenene: A Potential Therapeutic Agent for Acute Promyelocytic Leukaemia Cells by Acting on Nuclear Proteins

Wang

et al. 2020

Angewandte Chemie

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Arsenene has recently emerged as a promising new two‐dimensional material for biomedical applications because of its excellent optical and electronic properties. Herein, novel 2D arsenene nanosheets were synthesized and shown to be effective against NB4 promyelocytic leukaemia (APL) cells (82 % inhibition) as well as inducing apoptosis while showing no toxicity towards normal cells. The high zeta potential, small size, and the planar structure were crucial to the toxicity of the materials. Label‐free proteomic profiling analysis suggested that arsenene affected nuclear DNA replication, nucleotide excision repair, and pyrimidine metabolism pathways by downregulating the DNA polymerases POLE, POLD1, POLD2, and POLD3. Mass spectrometric studies showed that arsenene bound mainly to nuclear nucleotide acid binding proteins in NB4 cells and further cellular fluorescence studies revealed that the arsenene destroyed the nuclei. In vivo toxicity tests in mice also indicated the physiological biosafety of arsenene.

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“…The stability of BP@BTA guaranteed to continuously produce 1 O 2 with high efficiency (Figure S11, Supporting Information). Furthermore, the degradation products phosphate anions ensured its nontoxicity and biocompatibility …”

mentioning

confidence: 99%

“…Furthermore, the degradation products phosphate anions ensured its nontoxicity and biocompatibility. [32] Small 2019, 15,1901116 Next, we employed MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays to estimate biocompatibility of BP@BTA and its effect on Aβ-induced toxicity. PC12 cells without treatment were used as a control.…”

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confidence: 99%

Near‐Infrared Activated Black Phosphorus as a Nontoxic Photo‐Oxidant for Alzheimer's Amyloid‑β Peptide

Yang

Liu

et al. 2019

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The inhibition of amyloid‐β (Aβ) aggregation by photo‐oxygenation has become an effective way of treating Alzheimer's disease (AD). New near‐infrared (NIR) activated treatment agents, which not only possess high photo‐oxygenation efficiency, but also show low biotoxicity, are urgently needed. Herein, for the first time, it is demonstrated that NIR activated black phosphorus (BP) could serve as an effective nontoxic photo‐oxidant for amyloid‑β peptide in vitro and in vivo. The nanoplatform BP@BTA (BTA: one of thioflavin‐T derivatives) possesses high affinity to the Aβ peptide due to specific amyloid selectivity of BTA. Importantly, under NIR light, BP@BTA can significantly generate a high quantum yield of singlet oxygen (1O2) to oxygenate Aβ, thereby resulting in inhibiting the aggregation and attenuating Aβ‐induced cytotoxicity. In addition, BP could finally degrade into nontoxic phosphate, which guarantees the biosafety. Using transgenic Caenorhabditis elegans CL2006 as AD model, the results demonstrate that the 1O2‐generation system could dramatically promote life‐span extension of CL2006 strain by decreasing the neurotoxicity of Aβ.

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Black Phosphorus: Bioactive Nanomaterials with Inherent and Selective Chemotherapeutic Effects

Cited by 125 publications

References 52 publications

Augmenting Tumor‐Starvation Therapy by Cancer Cell Autophagy Inhibition

Augmenting Tumor‐Starvation Therapy by Cancer Cell Autophagy Inhibition

Arsenene: A Potential Therapeutic Agent for Acute Promyelocytic Leukaemia Cells by Acting on Nuclear Proteins

Near‐Infrared Activated Black Phosphorus as a Nontoxic Photo‐Oxidant for Alzheimer's Amyloid‑β Peptide

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