Black on Earth: African American Ecoliterary Traditions by Kimberly N. Ruffin (review)

Hicks, Scott

doi:10.1353/afa.2012.0041

Cited by 1 publication

(1 citation statement)

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“…1 Nationally, Black people comprise 12% of the US population but account for ≈40% of PLWH. 28 Black people also accounted for 41% of the 700 000 lives that have been lost to the HIV/AIDS pandemic in the United States. 29 Therefore, improved HIV surveillance and targeted intervention strategies are urgently needed to effectively address the complex challenges posed by the health disparities that continue to exacerbate the HIV epidemic.…”

Section: Disparities In Hiv Risk and Complications: Causes And Shared...mentioning

confidence: 99%

HIV-Associated Hypertension: Risks, Mechanisms, and Knowledge Gaps

Prakash,

Swami Vetha,

Chakraborty

et al. 2024

Circulation Research

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HIV type 1 (HIV-1) is the causative agent of AIDS. Since the start of the epidemic, HIV/AIDS has been responsible for ≈40 million deaths. Additionally, an estimated 39 million people are currently infected with the virus. HIV-1 primarily infects immune cells, such as CD 4+ (cluster of differentiation 4 + ) T lymphocytes (T cells), and as a consequence, the number of CD 4+ T cells progressively declines in people living with HIV. Within a span of ≈10 years, HIV-1 infection leads to the systemic failure of the immune system and progression to AIDS. Fortunately, potent antiviral therapy effectively controls HIV-1 infection and prevents AIDS-related deaths. The efficacy of the current antiviral therapy regimens has transformed the outcome of HIV/AIDS from a death sentence to a chronic disease with a prolonged lifespan of people living with HIV. However, antiviral therapy is not curative, is challenged by virus resistance, can be toxic, and, most importantly, requires lifelong adherence. Furthermore, the improved lifespan has resulted in an increased incidence of non-AIDS–related morbidities in people living with HIV including cardiovascular diseases, renal disease, liver disease, bone disease, cancer, and neurological conditions. In this review, we summarize the current state of knowledge of the cardiovascular comorbidities associated with HIV-1 infection, with a particular focus on hypertension. We also discuss the potential mechanisms known to drive HIV-1–associated hypertension and the knowledge gaps in our understanding of this comorbid condition. Finally, we suggest several directions of future research to better understand the factors, pathways, and mechanisms underlying HIV-1–associated hypertension in the post-antiviral therapy era.

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Section: Disparities In Hiv Risk and Complications: Causes And Shared...mentioning

confidence: 99%