Black Cummin Extract (Nigella sativa Linn) on Spatial Memory Performance in Menopausal Model of Rat

Safithri, Fathiyah; Andriani, Kusuma

doi:10.2991/hsic-17.2017.40

Cited by 2 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another aspect that may influence the effect of N. sativa in this study is the neuron's state at the moment N. sativa is administered. If the neurons that regulate the memory system have just diminished cell function and have not suffered structural damage because of the degeneration process, memory enhancements will be more obvious 30 .…”

Section: In-vivomentioning

confidence: 99%

Untitled

2022

IJPSR

View full text Add to dashboard Cite

Comprehensive search of previously published research was conducted in PubMed, Science Direct, Scopus, and google scholar databases for studies published between 2012 and August 2021. The keywords used in combination to search for articles included Nigella sativa and "Gynecology". In the first stage, the total articles obtained from searching the above databases using the above keywords were pooled together, and duplicate articles were removed. The remaining articles were primarily screened by reading the title and abstracts and selecting the most relevant articles. In the last stage, articles were reviewed again by reading the entire article, and those that did not meet the inclusion requirements were eliminated. A manual search was conducted using the reference list of the included research publications to collect additional data. In the various databases, the literature search found the following number of research articles: PubMed (n=11), Science Direct (n=35), Scopus (n=07), and Google Scholar (n=1070). After removing duplicates, there were 1062 articles. Those articles were further screened first by reading topics and abstracts and secondly, reading full text that did not match the inclusions was removed. After removing those articles, there were 40 articles, and after adding 05 manual search articles, finally, 45 articles were included in the systematic review. Nigella sativa has medicinal benefits for gynecological disorders such as PCOS, menopause-related issues, Hyperprolactinemia, Candidiasis, Trichomoniasis, Cervical cancer, Breast cancer, ovarian cancer, Premenstrual syndrome and Pre-eclampsia. Nigella sativa also improves endometrium, oocyte maturity and quality and reduces ovarian tissue damage without any adverse effects.

show abstract

Section: In-vivomentioning

confidence: 99%

Untitled

2022

IJPSR

View full text Add to dashboard Cite

show abstract

“…NS has a powerful constituent of antioxidants and protects against damage induced by the oxidative processes and the abilities to binding to protein targets. Thus, it may prevent neuronal cell death and improve cognitive function (8,(10)(11)(12) . NS, as a herbal medicine has been widely recognized for its potential biological activities, such as a diuretic, antihypertensive, antidiabetic, anticancer, immunomodulatory, antimicrobial, anthelmintic, analgesic, a spasmolytic, bronchodilator, anti-inflammatory, antitussive, gastroprotective, hepatoprotective, reduce LDL, renal protective and antioxidants (13)(14)(15)(16)(17)(18)(19)(20) .…”

Section: Introductionmentioning

confidence: 99%

In Silico Prediction of Potential Compounds of Nigella sativa as Aromatase Agonists and Ability to Cross the Blood-Brain Barrier for treatment of Alzheimer’s Disease

Andriana¹,

Nurdiana²,

Barlıanto³

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

View full text Add to dashboard Cite

Background: Alzheimer's disease (AD), is a chronic neurodegenerative disease which condition is characterized by a decline in memory, thinking skills, and the ability to perform basic activities of daily living. Study showed that postmenopausal women with AD had a lower aromatase activity (p450 aromatase) in the brain compared to menopausal women without AD. To improve cognitive function in AD patients, Nigella sativa (NS) was found to have a protective effect on memory, and cognitive function. This study therefore, aimed to investigate in silico prediction of potential compounds of Nigella sativa as aromatase agonists and ability to cross the Blood-Brain Barrier (BBB) for treatment of Alzheimer's Disease. Methods: The data sets used in this study were collected from databases KnapSack Kanaya, PubChem, and PASS server Way2Drug. HitPick and Autodock Vina was performed. Additionally, the systematic analysis involved ADMET, LMMD, and SWISS ADME. Results and Discussions: In silico test results revealed the most promising constituents in 36 active NS compounds that may have potential to reduce the severity of the AD, owing to its anti-inflammatory, cytochrome p450 stimulants, free radical scavengers, antioxidants, and immunomodulators. The ability of NS to cross the BBB was proven by admetSAR LMMD with an analysis average value of 0.91 (from the highest value of 1). Further, NS can trigger cytochrome P450 aromatase activity via Quercetin 3-(6'' ''-feruloylglucosyl)-(1->2)-galactosyl-(1->2)-glucoside which has a better binding affinity value than its control (androstenedione). NS through oleic acid compounds may bind to peroxisome proliferator-activated receptor gamma (PPRAG), similar to Rosiglitazone which may affect transcription and activation regulation of PPARG. Conclusion: To be concluded, Nigella sativa could be used as a potential medicinal plant for the treatment of Alzheimer's disease.

show abstract

Black Cummin Extract (Nigella sativa Linn) on Spatial Memory Performance in Menopausal Model of Rat

Abstract: ABSTRACT

Cited by 2 publications

References 31 publications

Untitled

Untitled

In Silico Prediction of Potential Compounds of Nigella sativa as Aromatase Agonists and Ability to Cross the Blood-Brain Barrier for treatment of Alzheimer’s Disease

Contact Info

Product

Resources

About