Black carp TAB1 up-regulates TAK1/IRF7/IFN signaling during the antiviral innate immune activation

Zou, Ziqi; Xie, Xinchi; Li, Wanzhen; Song, Xinhang; Tan, Yaqi; Wu, Hui; Xiao, Jun; Feng, Hao

doi:10.1016/j.fsi.2019.04.040

Cited by 13 publications

(8 citation statements)

References 41 publications

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“…The finding of these two domains in pompano TAK1 indicates the conserved functions of TAK1 in fishes and mammals. trTAB1 contained a sigma factor PP2C-like phosphatase (PP2C_SIG) domain (Figure 3B), in agreement with those of TAB1s in black carp [29], grass carp [24], orange-spotted grouper and large yellow croaker [22]. PP2C is a protein phosphatase involved in the regulation of the MAPK signaling pathway [47].…”

Section: Discussionsupporting

confidence: 67%

“…Thus far, TAK1 and/or TAB1 and/or TAB2 have been identified in several marine species, such as large yellow croaker (Larimichthys crocea) [22,23], grass carp (Ctenopharyngodon idellus) [24,25], orange-spotted grouper (Epinephelus coioides) [26,27], black carp (Mylopharyngodon piceus) [28,29], Japanese flounder (Paralichthys olivaceus) [30] and rainbow trout (Oncorhynchus mykiss) [31], providing valuable information about the roles of TAK1, TAB1 and TAB2 in fish innate immunity.…”

Section: Introductionmentioning

confidence: 99%

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Molecular Characterization and Expression Analysis of TAK1, TAB1 and TAB2 of Golden Pompano (Trachinotus ovatus)

Xie

Lei

et al. 2022

Fishes

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Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1), TAK1-binding protein 1 (TAB1) and TAB2 are components of the mitogen-activated protein kinase (MAPK) pathway. In this study, TAK1, TAB1 and TAB2 were characterized from golden pompano (Trachinotus ovatus), a marine fish of great economic value, and named as trTAK1, trTAB1 and trTAB2, respectively. The lengths of the cDNA sequences of the three genes were 2429 bp, 2068 bp and 4229 bp and encoded 575, 506 and 759 amino acids, respectively. The trTAK1, trTAB1 and trTAB2 genes shared high sequence identities and were well clustered with their counterparts from other fish species. Real-time qPCR analysis showed that the three genes were constitutively expressed in all the selected tissues of healthy pompano, and the expression levels of the three genes were significantly up-regulated in head kidney and spleen following Vibrio alginolyticus, lipolysaccharide (LPS) and polyinosinic polycytidylic acid (poly I:C) challenge, indicating their roles in the immune response against pathogens in golden pompano. Our results provide a basis for further study of the functions of these genes in golden pompano.

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Section: Discussionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Molecular Characterization and Expression Analysis of TAK1, TAB1 and TAB2 of Golden Pompano (Trachinotus ovatus)

Xie

Lei

et al. 2022

Fishes

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show abstract

“…Thirty-three proteins were found and matched entries in the InnateDB database. Most of these proteins are involved in immune-related functions such as protein binding (TAB1, SREBF2, HSP90AA1, RB1, STAT3, DCN, IL1R1, BNT3A2, PIK3R2, CCR6), transferase activity (TREM2, ABL1, S100A12, C4BPB), the protein dimerization (UBE2N, CSF1R) and lipopeptide binding (EPS8, CD36) [ 74 ].…”

Section: Artificial Intelligence Methods Vaccine Designmentioning

confidence: 99%

Artificial Intelligence Technologies for COVID-19 De Novo Drug Design

Floresta

Zagni

Gentile

et al. 2022

IJMS

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The recent covid crisis has provided important lessons for academia and industry regarding digital reorganization. Among the fascinating lessons from these times is the huge potential of data analytics and artificial intelligence. The crisis exponentially accelerated the adoption of analytics and artificial intelligence, and this momentum is predicted to continue into the 2020s and beyond. Drug development is a costly and time-consuming business, and only a minority of approved drugs generate returns exceeding the research and development costs. As a result, there is a huge drive to make drug discovery cheaper and faster. With modern algorithms and hardware, it is not too surprising that the new technologies of artificial intelligence and other computational simulation tools can help drug developers. In only two years of covid research, many novel molecules have been designed/identified using artificial intelligence methods with astonishing results in terms of time and effectiveness. This paper reviews the most significant research on artificial intelligence in de novo drug design for COVID-19 pharmaceutical research.

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“…Thirty-three proteins were found and matched entries in the InnateDB database. Most of these proteins are involved in immune-related functions such as protein binding (TAB1, SREBF2, HSP90AA1, RB1, STAT3, DCN, IL1R1, BNT3A2, PIK3R2, CCR6), transferase activity (TREM2 , ABL1, S100A12, C4BPB), the protein dimerization (UBE2N, CSF1R) and lipopeptide binding (EPS8, CD36) [71].…”

Section: Artificial Intelligence Methods Vaccine Designmentioning

confidence: 99%

Artificial Intelligence Technologies for COVID-19 De Novo Drug Design

Floresta¹,

Zagni²,

Gentile³

et al. 2022

Preprint

View full text Add to dashboard Cite

The recent covid crisis has proven important lessons for academia and industry regarding digital reorganization. Among fascinating lessons from these times is the huge potential of data analytics and artificial intelligence. The crisis exponentially accelerated the adoption of analytics and artificial intelligence, and this momentum is predicted to continue into the 2020s and over. Moreover, drug development is a costly and time-consuming business, and only a minority of approved drugs return the revenue that exceeds the research and development costs. As a result, there is a huge drive to make drug discovery cheaper and faster. With modern algorithms and hardware, it is not too surprising that the new technologies of artificial intelligence and other computational simulation tools can help drug developers. In only two years of covid research, many novel molecules have been designed/identified using artificial intelligence methods with astonishing results in terms of time and effectiveness. This paper will review the most significant research on artificial intelligence in the de novo drug design for COVID-19 pharmaceutical research.

show abstract

Black carp TAB1 up-regulates TAK1/IRF7/IFN signaling during the antiviral innate immune activation

Cited by 13 publications

References 41 publications

Molecular Characterization and Expression Analysis of TAK1, TAB1 and TAB2 of Golden Pompano (Trachinotus ovatus)

Molecular Characterization and Expression Analysis of TAK1, TAB1 and TAB2 of Golden Pompano (Trachinotus ovatus)

Artificial Intelligence Technologies for COVID-19 De Novo Drug Design

Artificial Intelligence Technologies for COVID-19 De Novo Drug Design

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