Black blood imaging of intracranial vessel walls

Chaganti, Joga; Woodford, Hannah; Tomlinson, Susan; Dunkerton, Sophie; Brew, Bruce J.

doi:10.1136/practneurol-2020-002806

Cited by 13 publications

(11 citation statements)

References 35 publications

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“…The recommended sequences for VWMRI include threedimensional time-of-flight (3D TOF) MRA, 3D and 2D T1WI, T2WI, PDWI, and contrast-enhanced T1WI sequences. Most of the intracranial VWMRI scanning protocols currently in clinical use rely on T1WI because the contrast-enhanced pre-and post-scan image characteristics allow the better differentiation of the plaques and their surrounding tissue structures and the better evaluation of plaque characteristics (17). The commonly used VWMRI sequence parameters are set out in Table 2.…”

Section: Multiple Tissue-weighted Sequencesmentioning

confidence: 99%

Application and interpretation of vessel wall magnetic resonance imaging for intracranial atherosclerosis: a narrative review

Li¹,

Wang²,

Hu³

et al. 2022

Ann Transl Med

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Background and Objective: Atherosclerosis is a systemic disease that occurs in the arteries, and it is the most important causative factor of ischemic stroke. Vessel wall magnetic resonance imaging (VWMRI) is one of the best non-invasive methods for displaying the vascular features of intracranial atherosclerosis. The main clinical applications of this technique include the exploration of the pathogenesis of intracranialatherosclerotic lesions, follow-up monitoring, and treatment prognosis judgment. As the demand for intracranial VWMRI increases in clinical practice, radiologists should be aware of the selection of imaging parameters and how they affect image quality, clinical indications, evaluation methods, and limitations in interpreting these images. Therefore, this review focused on describing how to perform and interpret VWMRI of intracranial atherosclerotic lesions. Methods: We searched the studies on the application of VWMRI in the PubMed database from January 1, 2000 to March 31, 2022, and focused on the analysis of related studies on VWMRI in atherosclerotic lesions, including technical application, expert consensus, imaging characteristics, and the clinical significance of intracranial atherosclerotic lesions.

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Section: Multiple Tissue-weighted Sequencesmentioning

confidence: 99%

Application and interpretation of vessel wall magnetic resonance imaging for intracranial atherosclerosis: a narrative review

Li¹,

Wang²,

Hu³

et al. 2022

Ann Transl Med

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“…Vessel wall magnetic resonance imaging (VWMRI) is currently one of the best imaging techniques for the noninvasive evaluation of intracranial atherosclerotic lesions (5). VWMRI had high spatial resolution and could directly image the vessel wall and lumen by suppressing blood signals, and it can identify distinct morphologic and enhancement patterns of atherosclerosis to provide important information about ischemic stroke etiology (6).…”

Section: Original Articlementioning

confidence: 99%

Lipid-lowering treatment in a rabbit model of atherosclerosis: a vessel wall magnetic resonance imaging study

Wu¹,

Li²,

Wang³

et al. 2022

Ann Transl Med

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Background: Vessel wall magnetic resonance imaging (VWMRI) is currently one of the best imaging techniques for the non-invasive evaluation of intracranial atherosclerotic lesions. However, it is still impossible to obtain pathological specimens of intracranial atherosclerotic plaques in vivo. The establishment of experimental animal models of atherosclerotic lesions similar to those of humans could solve this deficiency.Methods: A model of abdominal aortic atherosclerosis in New Zealand white rabbits was established using abdominal aortic balloon dilatation combined with high-fat fodder. The pathological results were used as the reference standard for the successful establishment of the animal model. The rabbits with abdominal aortic atherosclerosis were randomly divided into the lipid-lowering treatment and the normal-fodder control groups. VWMRI and blood biochemical examinations were performed at 4, 12, and 24 weeks, and the radiologic-pathologic correlations were established.Results: A rabbit abdominal aortic atherosclerosis model was established using balloon dilatation followed by high-fat fodder for 8 weeks. The lipid-lowering treatment reduced the plaque lipid core volume and decreased the plaque burden. However, it did not change plaque distribution, shape, or reverse vascular remodeling. Our pathological findings suggest that the lipid-lowering treatment reduced intraplaque macrophages but did not alter microvascular density.Conclusions: VWMRI accurately assessed the morphological changes of the plaques before and after the lipid-lowering treatment, and the results support the pathology results. VWMRI could be useful in experimental studies on the pathogenesis, diagnosis, and treatment of atherosclerotic lesions.

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“…6,7 Thus, HR-VWI enables further characterization of minute changes in the vessel wall. 2,5,[8][9][10] In HR-VWI, suppression of signals from the intraluminal blood and extraluminal CSF is required to precisely portray the vessel wall. 2,11,12 The 3D-T1-FSE sequence is widely used for HR-VWI due to its inherent black-blood (BB) effect attained by intravoxel dephasing induced by gradient moments and stimulated echoes.…”

mentioning

confidence: 99%

Improved Blood Suppression of Motion-Sensitized Driven Equilibrium in High-Resolution Whole-Brain Vessel Wall Imaging: Comparison of Contrast-Enhanced 3D T1-Weighted FSE with Motion-Sensitized Driven Equilibrium and Delay Alternating with Nutation for Tailored Excitation

Kim

Lee

Baik

et al. 2022

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: High-resolution vessel wall MR imaging is prone to slow-flow artifacts, particularly when gadolinium shortens the T1 relaxation time of blood. This study aimed to determine the optimal preparation pulses for contrast-enhanced high-resolution vessel wall MR imaging. MATERIALS AND METHODS:Fifty patients who underwent both motion-sensitized driven equilibrium and delay alternating with nutation for tailored excitation (DANTE) preparation pulses with contrast-enhanced 3D-T1-FSE were retrospectively included. Qualitative analysis was performed using a 4-grade visual scoring system for black-blood performance in the small-sized intracranial vessels, overall image quality, severity of artifacts, and the degree of blood suppression in all cortical veins as well as transverse sinuses. Quantitative analysis of the M1 segment of the MCA was also performed. RESULTS:The qualitative analysis revealed that motion-sensitized driven equilibrium demonstrated a significantly higher black-blood score than DANTE in contrast-enhanced 3D-T1-FSE of the A3 segment (3.90 versus 3.58, P , .001); M3 (3.72 versus 3.26, P = .004); P2 to P3 (3.86 versus 3.64, P = .017); the internal cerebral vein (3.72 versus 2.32, P , .001); and overall cortical veins (3.30 versus 2.74, P , .001); and transverse sinuses (2.82 versus 2.38, P , .001). SNR lumen , contrast-to noise ratio wall-lumen , and SNR wall in the M1 vessel were not significantly different between the 2 preparation pulses (all, P . .05).CONCLUSIONS: Motion-sensitized driven equilibrium demonstrated improved blood suppression on contrast-enhanced 3D-T1-FSE in the small intracranial arteries and veins compared with DANTE. Motion-sensitized driven equilibrium is a useful preparation pulse for high-resolution vessel wall MR imaging to decrease venous contamination and suppress slow-flow artifacts when using contrast enhancement.ABBREVIATIONS: BB ¼ black-blood; CE ¼ contrast-enhanced; CNR ¼ contrast-to-noise ratio; DANTE ¼ delay alternating with nutation for tailored excitation; HR-VWI ¼ high-resolution vessel wall MR imaging; ICV ¼ internal cerebral vein; MSDE ¼ motion-sensitized driven equilibrium

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Black blood imaging of intracranial vessel walls

Cited by 13 publications

References 35 publications

Application and interpretation of vessel wall magnetic resonance imaging for intracranial atherosclerosis: a narrative review

Application and interpretation of vessel wall magnetic resonance imaging for intracranial atherosclerosis: a narrative review

Lipid-lowering treatment in a rabbit model of atherosclerosis: a vessel wall magnetic resonance imaging study

Improved Blood Suppression of Motion-Sensitized Driven Equilibrium in High-Resolution Whole-Brain Vessel Wall Imaging: Comparison of Contrast-Enhanced 3D T1-Weighted FSE with Motion-Sensitized Driven Equilibrium and Delay Alternating with Nutation for Tailored Excitation

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