Black bean extract ameliorates liver fibrosis in rats with CCl4-induced injury

López‐Reyes, Alberto; Arroyo‐Currás, Netzahualcóyotl; Cano, Beiman G; Díaz, Víctor J.; Guajardo-Salinas, Gustavo E.; Islas, José Francisco; Morales-Oyarvide, Vicente; Morales-Garza, Luis Alonso; Gálvez-Gastélum, Francisco Javier; Grijalva, Guillermo; Moreno-Cuevas, Jorge E.

doi:10.1016/s1665-2681(19)31868-x

Cited by 20 publications

(8 citation statements)

References 26 publications

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“…10 In addition, BBE has been shown to inhibit liver brosis. 5 The ndings of the present study were consistent with previous observations on the use of BBE, which demonstrated an antibrotic effect in a murine model of liver cirrhosis. In that model, rats treated with CCl 4 were either untreated treated with BBE by intragastric administration.…”

Section: Bbe and The Anti-brotic Effectsupporting

confidence: 92%

“…4 In addition, López-Reyes et al (2008) demonstrated that a methanolic BB extract (BBE) reduced expression of types I and IV collagen in a hepatic brosis murine model. 5 Particularly, a previous study demonstrated that BB hulls had higher anti-inammatory potential compared to counterparts obtained from pink or pinto beans. 6 In addition, BB coat contains a number avonoids and saponins, which are have been described as having immunomodulatory 7 and anticytotoxic activities 8 and, more recently, anti-brotic effects.…”

Section: Introductionmentioning

confidence: 98%

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Standardized extracts from black bean coats (Phaseolus vulgaris L.) prevent adverse cardiac remodeling in a murine model of non-ischemic cardiomyopathy

et al. 2015

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Section: Bbe and The Anti-brotic Effectsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 98%

Standardized extracts from black bean coats (Phaseolus vulgaris L.) prevent adverse cardiac remodeling in a murine model of non-ischemic cardiomyopathy

et al. 2015

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“…In excessive use of APAP, the NAPQI causes an imbalance between the production and removal of free radicals and leading to oxidative stress (Tezcan et al, 2018;Jaeschke, 2015). The factors progressing chronic liver disease are free radical-induced oxidative stress and chronic inflammation resulting from the release of proinflammatory cytokines from the liver Kupffer cells (L opez-Reyes et al, 2008). The enzymatic and non-enzymatic defense systems of the normal hepatocytes protect them against free radicals and reactants; the enzymatic defense system includes catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPX) which rapidly react with and remove reactive oxygen species (ROSs) such as superoxide, hydrogen peroxide and hydroxyl radical (Mansourian et al, 2018;Lee et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective and antioxidant activity of hydroalcoholic extract of Stachys pilifera. Benth on acetaminophen-induced liver toxicity in male rats

Mansourian

Mirzaei

Azarmehr

et al. 2019

Heliyon

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Background: Acetaminophen (APAP) at high doses causes adverse side effects such as hepatotoxicity. The aim of the current study was to investigate the hepatoprotective and antioxidant effects of hydroalcoholic extract of Stachys pilifera. Benth (SP) on hepatotoxicity induced by APAP in male rats. Methods: Adult male Wistar rats were allocated into four groups: control (C), APAP (2 g/kg), APAP þ SP (500 mg/ kg), and APAP þ Silymarin (SM, 100 mg/kg) as positive control group. On the seventh day, the rats were sacrificed after taking blood samples. Then levels of biochemical parameters, oxidative stress markers and activity of antioxidant enzymes were measured. Results: In the APAP group, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzymes activity was significantly increased and the level of protein carbonyl (PCO) was insignificantly increased as compared to control group. In addition, the activity of glutathione peroxidase (GPX) and total thiol in the APAP group was significantly decreased compared to the normal rats. Stachys pilifera. Benth extract administration significantly reduced the activity of AST and ALT enzymes and the level of PCO compared to the APAP group, while significantly elevated the activity of GPX enzyme. Conclusion: Hydroalcoholic extract of SP diminishes hepatotoxicity induced by APAP by reducing the amount of liver function indicators (AST and ALT). Furthermore, the hydroalcoholic extract of SP is capable of reducing oxidative stress through inhibiting protein oxidation as well as boosting the activity of GPX enzyme. In this respect, the hepatoprotective impact induced by the SP extract may possibly be attributable to its reactive oxygen species scavenging and antioxidant properties.

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“… S. No. Plant Family Part/Extract/Active ingredient Experimental model Type of study Biomarkers/parameters affected Reference 1 Black bean Fabaceae Methanolic extract CCl 4 induced In vivo ↓liver types I and IV collagen 89 2 Pureria lobata Fabaceae Purerin Alchol + CCl 4 induced In vivo ↓serum AST, ALT, bcl-2 mRNA expression; ↑apoptosis of HSCs 90 3 Astragalus complanatus Fabaceae Flavonoids NDMA induced In vivo ↑SOD, MMP-1 mRNA, ↓MDA, serum PINP and PIIINP and TIMP-1 91 4 Astragalus membranaceous Fabaceae Root extract CCl 4 induced In vivo ↓serum transaminases, hyaluronic acid, laminin and procollagen type III levels, and contents of hydroxyproline, LPO and TGF-β; ↑SOD and GSH-Px; ↓thymidine and proline incorporation. 92 5 Glycyrrhiza glabra Fabaceae Glycyrrhetinic Acid CCl 4 induced In vivo ↓ALT, AST, MAO, LPO; ↑Nrf2, SOD 3, GPX2 and CAT 63 6 Cichorium glandulosum Compositae/ Asteraceae Root extract (petroleum ether, ethyl acetate, and n-butyl alcohol) CCl 4 induced In vivo ↓serum AST, ALT, FN, Smard3 and TGF-β1; ↑apoptotic index 93 7 Silybum marianum Asteraceae Silymarin CCl 4 induced In vivo ↓serum AST, ALT, ALP hepatic α-SMA 36 8 Artemisia iwayomogi Asteraceae <...>…”

Section: Current Phyto-products In Treating Liver Fibrosismentioning

confidence: 99%

Herbal remedies for liver fibrosis: A review on the mode of action of fifty herbs

Latief

Ahmad

2018

Journal of Traditional and Complementary Medicine

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Liver fibrosis is a dynamic pathological condition which can be slowed down in its initial phases. Without proper clinical management of fibrosis, progressive liver damage may lead to cirrhosis and ultimately to liver failure or primary liver cancer, which are irreversible conditions. Therefore, in order to cure fibrotic damage to liver, its early stages should be the centre of attention. In this context, some supplements and ‘complementary and alternative medicine (CAM)’ deserve specific mention, because of their already recognized natural way of healing and long lasting curative effects. Moreover, CAM display negligible side effects and hence it is gaining worldwide importance in clinical practices. In particular, herbal medicines are now replacing synthetic pharmaceuticals and looked upon as the sources of novel bioactive substances. To develop satisfactory herbal combinations for treating liver fibrosis, phytoproducts need to be systematically evaluated for their potency as anti-fibrotic, anti-hepatotoxic and antioxidant agents. More importantly, the identified herb/agent should have the remarkable tendency to stimulate hepatocytes regeneration. The present review is a systematic account of at least fifty medicinal herbs and their products which in experimental models have demonstrated antifibrotic activity and thus, most likely candidates to offer therapeutic protection to liver. Nevertheless, much additional work is still needed to explore molecular pathways to discover potential applications of these medicines so as to open up new vistas in biomedical research.

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Black bean extract ameliorates liver fibrosis in rats with CCl4-induced injury

Cited by 20 publications

References 26 publications

Standardized extracts from black bean coats (Phaseolus vulgaris L.) prevent adverse cardiac remodeling in a murine model of non-ischemic cardiomyopathy

Standardized extracts from black bean coats (Phaseolus vulgaris L.) prevent adverse cardiac remodeling in a murine model of non-ischemic cardiomyopathy

Hepatoprotective and antioxidant activity of hydroalcoholic extract of Stachys pilifera. Benth on acetaminophen-induced liver toxicity in male rats

Herbal remedies for liver fibrosis: A review on the mode of action of fifty herbs

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