BLACAT1 predicts poor prognosis and serves as oncogenic lncRNA in small‐cell lung cancer

Chen, Weiwei; Ye, Hang; Xu, Weiwei; Wu, Jixiang; Chen, Longyun; Chen, Jinzhong; Mao, Yiming; Song, Jin Ho; Wang, Hanhua

doi:10.1002/jcb.27548

Cited by 33 publications

(21 citation statements)

References 22 publications

(58 reference statements)

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“…9 BLACAT1 high-expression acts as a poor outcome biomarker for overall survival in small-cell lung cancer. 10 Importantly, BLACAT1 elevates the oxaliplatinresistance of GC by enhancing ABCB1 protein expression through inhibiting miR-361. 11 However, the detailed mechanism of BLACAT1 on the occurrence and development of GC needs to be further explored.…”

Section: Introductionmentioning

confidence: 99%

Long Non-Coding RNA BLACAT1 Promotes the Tumorigenesis of Gastric Cancer by Sponging microRNA-149-5p and Targeting KIF2A

Wang¹,

Liu²,

Niu³

2020

CMAR

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Objective: Gastric cancer (GC) is a gastrointestinal tumor. This study is aimed to explore the regulatory mechanism of long non-coding RNA BLACAT1 (BLACAT1)/microRNA-149-5p (miR-149-5p)/KIF2A cascade on GC. Methods: The expression of BLACAT1, miR-149-5p and KIF2A in GC was detected by qRT-PCR. The proliferation, migration and invasion of GC cells in vitro were analyzed by MTT, wound-healing and transwell assay, respectively. The xenograft tumor model was constructed in nude mice to confirm the inhibition effect of BLACAT1 knockdown on GC in vivo. Then, dual-luciferase reporter assay was used to detect the interactions among BLACAT1, miR-149-5p and KIF2A. Western blot assay was performed to determine the protein expression of KIF2A. Results: The expression of BLACAT1 and KIF2A was up-regulated in GC, but miR-149-5p expression was down-regulated. Silencing of BLACAT1 retarded the proliferation, migration and invasion of GC cells in vitro and the growth of tumor xenograft in vivo. Moreover, BLACAT1 acted as the molecular sponge of miR-149-5p to up-regulate KIF2A expression. At last, feedback experiments suggested that BLACAT1 accelerated the proliferation, migration and invasion of GC cells by regulating miR-149-5p/KIF2A axis. Conclusion: BLACAT1 facilitated the tumorigenesis of GC through regulating miR-149-5p/KIF2A axis, which indicated BLACAT1/miR-149-5p/KIF2A cascade may be a new therapeutic target.

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Section: Introductionmentioning

confidence: 99%

Long Non-Coding RNA BLACAT1 Promotes the Tumorigenesis of Gastric Cancer by Sponging microRNA-149-5p and Targeting KIF2A

Wang¹,

Liu²,

Niu³

2020

CMAR

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“…LncRNAs have been reported to regulate gene expression in various cancers. 22 JAK2, as an upstream of JAK2/STAT3 signaling pathway, was selected for its cellular function in tumors in accordance with the role of LINC00511. Besides, previous studies have showed that proteins involved in signaling pathways can affect the radioresistance of tumors.…”

Section: Linc00511 Regulates Jak2/stat3 Signaling Pathwaymentioning

confidence: 99%

Knockdown of LINC00511 promotes radiosensitivity of thyroid carcinoma cells via suppressing JAK2/STAT3 signaling pathway

Chen

Bao

Zhang

et al. 2019

Cancer Biology & Therapy

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Thyroid carcinoma is the most widespread malignancy in endocrine system with the increasing incidence. Despite of the advanced approaches to the management of thyroid carcinoma, the therapeutic effects remain unpleasant largely due to the radiosensitivity of thyroid carcinoma cells. LncRNAs play important part in the tumorigenesis and development, especially in the radiosensitivity of tumor cells. However, their roles in thyroid carcinoma still needed to be explored deeply. The purpose of our research is to inspect the possible biological role and regulation mechanism of LINC00511 desirable for therapies of thyroid carcinoma patients. In the present study, LINC00511 was significantly overexpressed in thyroid carcinoma and its silencing boosted radiosensitivity of thyroid carcinoma cells. Then we unveiled that LINC00511 regulated JAK2/STAT3 signaling pathway which was resistant to radiation treatment. Besides, TAF1 modulated JAK2 at transcriptional level. Moreover, LINC00511 bound to TAF1 and further promoted JAK2 expression. In conclusion, rescue experiments verified that the radiosensitivity of thyroid carcinoma cells was attributed to LINC00511/TAF1/JAK2/STAT3 axis. The current paper investigated the underlying mechanism of LINC00511 and set a new therapeutic direction for the therapy of thyroid carcinoma.

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“…Functionally, knockdown of BLACAT1 was found to attenuate cell proliferation, migration, invasion, and arrest G0/G1 cell cycle in SCLC cells. 29 Taken together, BLACAT1 could potentially serve as a novel prognostic predictor and therapeutic target for lung cancer patients ( Figure 1B).…”

Section: Blacat1 In Lung Cancermentioning

confidence: 90%

Long Non-Coding RNA BLACAT1 in Human Cancers

Tao¹,

Yang²,

Liu³

et al. 2020

OTT

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Long non-coding RNAs (lncRNAs) are a cluster of RNAs with more than 200 nucleotides in length, which lack protein-coding capacity. They are important regulators of numerous cellular processes, including gene transcription, translation, and posttranslational modification, especially in tumor initiation and progression. Aberrant expression of lncRNA bladder cancer-associated transcript 1 (BLACAT1) has been reported in various human cancers and was usually associated with unfavorable prognosis. Previous studies have revealed that dysregulation of BLACAT1 could promote the proliferation and metastasis of cancer cells. In this review, we summarize the present understanding of the functions and underlying mechanisms of BLACAT1 in the occurrence and development of various human cancers and discuss the roles of this lncRNA in cancers, including its promising application as a prognostic biomarker or a novel therapeutic target for malignancies.

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BLACAT1 predicts poor prognosis and serves as oncogenic lncRNA in small‐cell lung cancer

Cited by 33 publications

References 22 publications

<p>Long Non-Coding RNA BLACAT1 Promotes the Tumorigenesis of Gastric Cancer by Sponging microRNA-149-5p and Targeting KIF2A</p>

<p>Long Non-Coding RNA BLACAT1 Promotes the Tumorigenesis of Gastric Cancer by Sponging microRNA-149-5p and Targeting KIF2A</p>

Knockdown of LINC00511 promotes radiosensitivity of thyroid carcinoma cells via suppressing JAK2/STAT3 signaling pathway

<p>Long Non-Coding RNA BLACAT1 in Human Cancers</p>

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