Untitled

Abstract

The effect of Berhi date extract on the ultrastructure of Candida albicans was studied by scanning and transmission electron microscopy. Exposure of yeast to 5% (w/v) date extract showed evidence of weakening in the cell wall with indications of cell distortion and partial collapse in some cases as seen by scanning electron microscopy. Increasing the concentration of date extract (20%, w/v) led to more drastic damage to the yeast with cell lysis and concurrent leakage of cytoplasmic material with eventual cell death. Ultrastructural investigation showed irregular shapes of cells treated with date extract, with prominent effects on cell wall layers. Cell membranes lost their integrity, aggregation of the cytoplasmic contents and large detachment of plasmalemma from cell wall was observed in the treated cells. These results suggest that date extract may have multiple effects on Candida with an increasing potential of using it for prophylaxis purposes.

Anti-coccidial and anti-apoptotic activities of palm pollen grains on Eimeria papillata-induced infection in mice

“…Its fruit extract was found to have a strong antibacterial (Saddiq & Bawazir 2010), anti-fungal (Shraideh et al 1998), antiparasitic (Metwaly et al 2012a), antiviral (Jassim & Naji 2010) and hepatoprotective activities (Al-Qarawi et al 2004;Saafi et al 2011;Metwaly et al 2012b). Among the common products of palm tree is their male gametophytes known as palm pollens.…”

Synthesis and Reactions of New Thienopyridines, Pyridothieniopyrimidines and Pyridothienotriazines

“…1,2 Several thieno [2,3-b]pyridine derivatives are known to possess antibacterial, [3][4][5] antihypertensive 6 and gonadotropinreleasing hormone antagonizing 7,8 activity. Pyridothienopyrimidine derivatives have been found applications as analgesics, 9 antipyretics 10 and anti-inflammatories.…”

Synthesis of some fused heterocycles based on thieno[2,3-b]pyridine and their antimicrobial activity

“…Among these heterocycles the thienopyrimidine class is also of interest because some derivatives such as Tiprinast [4] have been shown to be clinically effective antiallergics. Several thieno[2,3-b]pyridine derivatives are known to possess antibacterial [5][6][7], antihypertensive [8], and gonadotropin releasing hormone antagonizing [9, 10] activity.Many thienopyridines have been evaluated pharmacologically and have been found to show activity in diabetes mellitus [11][12][13] and also as analgesics and anti-inflammatory agents [14][15][16], sedatives [14], anticoagulants [16], and antiartherosclerotics [17][18][19][20]. Considerable attention has been drawn to the synthesis of condensed heterocyclic systems derived from 1,2,4-triazoles, pyrazoles, and pyridothienopyrimidine [21][22][23][24][25].…”

“…Among these heterocycles the thienopyrimidine class is also of interest because some derivatives such as Tiprinast [4] have been shown to be clinically effective antiallergics. Several thieno[2,3-b]pyridine derivatives are known to possess antibacterial [5][6][7], antihypertensive [8], and gonadotropin releasing hormone antagonizing [9, 10] activity.…”

“…Its 1 H NMR spectrum showed signals at δ 5.22 and 6.32 because of NH and H-5 of the cyclized pyrimidine ring. On the other hand, 7,9-dimethyl-2,3-dihydroimidazo[1,2-c]pyrido [3',2':4,5]thieno [2,3-e]pyrimidine-5-thione (5) was obtained by heating compound 2 with CS 2 in boiling pyridine. The IR spectrum of compound 5 showed absorption bands at 3250 (NH) and 1220 cm -1 (C=S).…”