BK Virus Nephropathy in the Native Kidney of a Liver Transplant Recipient

Sekulic, Miroslav; Sloan, Richard P.; Guo, Shunhua; Anderson, Mary R.; Markowitz, Glen S.

doi:10.1016/j.ekir.2021.03.888

Cited by 2 publications

(2 citation statements)

References 9 publications

(28 reference statements)

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“…BK virus infection of the native kidney after liver transplant is rare, though possibly underrecognised, with only three cases previously reported to the best of our knowledge [ 9 – 11 ]. Recognition of haematological manifestations of polyomavirus are increasing.…”

Section: Discussionmentioning

confidence: 99%

BK viraemia as a cause of anaemia in after ABO-incompatible liver transplant: a case report

McMullen,

Khoo,

Anderson

et al. 2023

BMC Infect Dis

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Background While anaemia following liver transplant is common, anaemia in the context of BK viraemia is not a commonly recognised phenomenon. Case presentation We present the case of 59-year old gentleman with severe anaemia in the context of BK viraemia and nephropathy following ABO incompatible liver transplant. Severity of anaemia appeared to correlate with high titres of BK virus in the serum. Bone marrow biopsy revealed hypocellular marrow with normal cytogenetics. Anaemia improved with treatment with cidofovir, intravenous immunoglobulin, reduction in immunosuppression and erythropoietin stimulating agent. Conclusion To our knowledge, this is the first case of anaemia post liver transplant contributed to by BK viraemia.

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Section: Discussionmentioning

confidence: 99%

BK viraemia as a cause of anaemia in after ABO-incompatible liver transplant: a case report

McMullen,

Khoo,

Anderson

et al. 2023

BMC Infect Dis

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“…However, this is rare, and BKVN is not usually considered in the differential diagnosis for acute kidney injury (AKI) in NRSOT patients. [2][3][4][5] Here, we report a case of BKVN involving the native kidneys of a patient who had undergone recent ureteral stenting 13 years after orthotopic heart transplantation (OHT).…”

Section: Introductionmentioning

confidence: 99%

Native BK Polyomavirus Nephropathy in an Orthotopic Heart Transplant Patient

Thompson

Ajene

Kulkarni

et al. 2023

Journal of Investigative Medicine High Impact Case Reports

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BK polyomavirus nephropathy (BKVN) is a common cause of nephropathy in kidney transplant patients and is typically seen within the first year after transplantation. BK polyomavirus nephropathy can occur in the native kidneys of patients with nonrenal solid-organ transplants (NRSOT). However, this is rare, especially outside the early post-transplant period, and BKVN is not usually considered in the differential diagnosis for acute kidney injury in NRSOT patients. We present a case of a 75-year-old man who had undergone orthotopic heart transplant 13 years prior with stable allograft function who developed progressive renal dysfunction in the setting of recent unilateral obstructive nephrolithiasis requiring ureteral stenting. Kidney biopsy demonstrated evidence of polyomavirus nephritis. Serum BK viral load was elevated. Despite reducing immunosuppression and initiating leflunomide, viral clearance was never achieved. The patient experienced progressive failure to thrive before ultimately transitioning to hospice care and dying. The intensity of immunosuppression is a well-known risk factor for viral replication; ureteral stenting has also been associated with BKVN. However, since clinical manifestations of BK viral infections often include a genitourinary (GU) tract pathology, it is important for clinicians to consider BKVN in patients with NRSOT with progressive renal dysfunction, especially in the clinical context of known GU disease.

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BK Virus Nephropathy in the Native Kidney of a Liver Transplant Recipient

Cited by 2 publications

References 9 publications

BK viraemia as a cause of anaemia in after ABO-incompatible liver transplant: a case report

BK viraemia as a cause of anaemia in after ABO-incompatible liver transplant: a case report

Native BK Polyomavirus Nephropathy in an Orthotopic Heart Transplant Patient

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