Bk Virus-Associated Fatal Renal Failure Following Late-Onset Hemorrhagic Cystitis in an Unrelated Bone Marrow Transplantation

Iwamoto, Shotaro; Azuma, Eiichi; Hirayama, Masahiro; Kobayashi, Michihiro; Komada, Yoshihiro; Nishimori, Hisashi; Miyahara, Masazumi; Nishide, Yoshiya

doi:10.1080/08880010252899424

Cited by 45 publications

(23 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in some cases, high attention is focused on the fatal outcome of urinary tract obstruction. 4,37 Despite maximum efforts, effective therapy of LOHC has not been established until now. Base management including hyperhydration, bladder irrigation and transfusional support are often ineffective.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Selective embolization of the internal iliac arteries for the treatment of severe hemorrhagic cystitis following hematopoietic SCT

Han

Sun

et al. 2008

Bone Marrow Transplant

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

“…4,5 Its reported incidence ranges from less than 10% to more than 70% due to the discrepancies in definition criteria and the types of transplant. 6,7 Furthermore, severe HC requires prolongation of hospitalization and even finally leads to death.…”

Section: Introductionmentioning

confidence: 99%

Selective embolization of the internal iliac arteries for the treatment of severe hemorrhagic cystitis following hematopoietic SCT

Han

Sun

et al. 2008

Bone Marrow Transplant

View full text Add to dashboard Cite

“…Clinical syndromes vary from microscopic hematuria to macroscopic hematuria, dysuria, and flank pain with or without renal insufficiency. Both BK polyoma virus and adenovirus are known to cause hemorrhagic cystitis after HCT; however, it is not clear whether viremia and viruria lead to renal insufficiency (68,69) (Figure 4). In a report of 21 autopsied transplant patients …”

Section: Viral Infections and Renal Diseasementioning

confidence: 99%

Chronic Kidney Disease in Long-Term Survivors of Hematopoietic Cell Transplantation

Hingorani

2006

Journal of the American Society of Nephrology

128

111

View full text Add to dashboard Cite

High-dose myeloablative hematopoietic cell transplantation is becoming an increasingly common treatment modality for a variety of diseases. Patient survival may be limited by substantial treatment-related toxicities, including chronic kidney disease (CKD). Although the majority of CKD after transplantation is idiopathic, thrombotic microangiopathic syndromes and nephrotic syndrome have been described. Epidemiology, pathogenesis, and potential treatment options for the various clinical syndromes that are associated with CKD in hematopoietic cell transplantation patients is reviewed. As the indications for and the numbers of transplants that are performed worldwide increases, so will the burden of CKD. The nephrologists and oncologists will have to work together to identify patients who are at risk for CKD early to prevent its development and progression to end-stage kidney disease. 17: 199517: -200517: , 200617: . doi: 10.1681 H igh-dose myeloablative therapy followed by hematopoietic cell transplantation (HCT) is an increasingly common treatment for many malignancies and some genetic disorders. Approximately 20,000 HCTs now are performed annually worldwide and offer the prospect of cures for otherwise fatal or incurable diseases. The indications and applications for HCT are growing; for example, HCT now is considered for treatment of autoimmune diseases, Crohn's disease, and vasculitides that are refractory to other therapies (1,2). However, patient survival may be limited by substantial treatment-related toxicities. J Am Soc NephrolThis review focuses on chronic kidney disease (CKD) in survivors of HCT. For the nephrology consultant who deals with transplant survivors, it is important to be aware of the specific type of transplant and its complications to determine how best to treat the patient with renal injury secondary to thrombotic microangiopathy (TMA) syndromes, nephrotic syndrome (NS), persistent acute renal failure (ARF), and idiopathic CKD. Technique of HCTEach type of transplant carries its own risks and toxicities (Table 1). Autologous transplants involve the harvesting of a patient's own bone marrow or peripheral blood stem cells before high-dose myeloablative therapy, followed by re-infusion. Allogeneic transplants use bone marrow or peripheral blood stem cells from family members (ideally, HLA-matched siblings) or HLAmatched unrelated donors or stem cells from umbilical cord blood.Syngeneic transplants are from an identical twin donor. The infusion of stem cells is preceded by either myeloablative therapy (usually a combination of chemotherapy drugs or chemotherapy plus total body irradiation [TBI]) or nonmyeloablative (but immunosuppressive) therapy that allows host hematopoietic cells to coexist with donor stem cells to achieve mixed hematopoietic cell chimerism. The components of both myeloablative and nonmyeloablative conditioning regimens vary from center to center. The most common myeloablative regimens are cyclophosphamide plus TBI 10 to 14 Gy, busulfan plus cyclophosphamide, and busulf...

show abstract

“…BKV initiates an asymptomatic, lifelong persistent infection in approximately 80 to 90% of healthy human adults (6,27,48). The reactivation of BKV occurs during immunosuppression following kidney or bone marrow transplantation (17,24). Transplant recipients receiving more intensive immunosuppressive regimens are at a higher risk of viral reactivation (3).…”

Section: The Human Polyomavirus Bk Virus (Bkv) Is a Common Virus For mentioning

confidence: 99%

Transcriptional Regulation of BK Virus by Nuclear Factor of Activated T Cells

Jordan

Manley

Dugan

et al. 2010

J Virol

View full text Add to dashboard Cite

The human polyomavirus BK virus (BKV) is a common virus for which 80 to 90% of the adult population is seropositive. BKV reactivation in immunosuppressed patients or renal transplant patients is the primary cause of polyomavirus-associated nephropathy (PVN). Using the Dunlop strain of BKV, we found that nuclear factor of activated T cells (NFAT) plays an important regulatory role in BKV infection. Luciferase reporter assays and chromatin immunoprecipitation assays demonstrated that NFAT4 bound to the viral promoter and regulated viral transcription and infection. The mutational analysis of the NFAT binding sites demonstrated complex functional interactions between NFAT, c-fos, c-jun, and the p65 subunit of NF-B that together influence promoter activity and viral growth. These data indicate that NFAT is required for BKV infection and is involved in a complex regulatory network that both positively and negatively influences promoter activity and viral infection.

show abstract

Bk Virus-Associated Fatal Renal Failure Following Late-Onset Hemorrhagic Cystitis in an Unrelated Bone Marrow Transplantation

Cited by 45 publications

References 18 publications

Selective embolization of the internal iliac arteries for the treatment of severe hemorrhagic cystitis following hematopoietic SCT

Selective embolization of the internal iliac arteries for the treatment of severe hemorrhagic cystitis following hematopoietic SCT

Chronic Kidney Disease in Long-Term Survivors of Hematopoietic Cell Transplantation

Transcriptional Regulation of BK Virus by Nuclear Factor of Activated T Cells

Contact Info

Product

Resources

About