Biventricular metastatic invasion from cervical squamous cell carcinoma

Kapoor, Karan; Evans, Matthew C.; Shkullaku, Melsjan; Schillinger, Rachel M.; White, Charles S.; Roque, Dana M.

doi:10.1136/bcr-2016-214931

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…Of the few reported cases of cervical cardiac metastasis, three cases demonstrated left ventricular involvement but none of the reported cases demonstrated septal involvement which was seen in our patient. 1 The clinical manifestations of cardiac metastasis vary depending on tumor location and size. Symptoms can range from chest pain, fatigue, weight loss, congestive heart failure from intracardiac obstruction, valvular pathologies, and features of pericardial effusion, while most common presentations are symptoms of heart failure, chest pain, and palpitations.…”

Section: Discussionmentioning

confidence: 99%

“…As per current literature, fewer than 12 live cases of cervical metastasis to the heart have been reported. 1 With improvements in oncological therapies and associated survival benefits, the incidence of cardiac metastasis may increase. The majority of cardiac metastases emerge from primary lung cancer (36-39%), breast cancer (10%), and hematologic malignancies (10-20%).…”

Section: Introductionmentioning

confidence: 99%

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A Rare Case of Cervical Cancer Metastasis to the Heart

Muhyieddeen,

Balla,

Rasheed

et al. 2023

Preprint

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Background: Most cardiac metastases emerge from primary lung, breast, and hematologic malignancies. The clinical manifestations of cardiac metastasis vary depending on tumor location and size. Cardiac metastasis from cervical squamous cell carcinoma is extremely rare and is mostly found on autopsy. We report a case of cervical cancer metastasis to the interventricular septum. Case Summary. This report discusses the case of a 48-year-old woman with interventricular septal metastases, originating from squamous cell carcinoma of the cervix. The woman came to our hospital after experiencing a fainting spell. Her hospital stay was notable for a brief syncopal event during a 30-second asystole episode, which ended spontaneously. Upon awakening, she reported severe chest pain. In response, she was quickly taken to the catheterization laboratory. There, a coronary angiography revealed an 80% blockage in her left anterior descending artery. Two years prior, our patient was diagnosed with invasive squamous cell cervical carcinoma with PET/CT showing no evidence of metastatic disease. A repeat PET/CT scan was done following cardiac catheterization and was significant for a mass along the interventricular septum of the heart. Discussion. Cardiac metastasis from primary cervical squamous cell carcinomas is scarcely reported in medical literature. Among these rare cases, the majority involved the right ventricle, with only three involving the left ventricle. There are no documented instances of metastasis to the interventricular septum. To our knowledge, this would be the first such case.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Rare Case of Cervical Cancer Metastasis to the Heart

Muhyieddeen,

Balla,

Rasheed

et al. 2023

Preprint

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“…CT and cardiac magnetic resonance (CMR) can help to accurately determine the size and extension of the tumor mass, and CMR is the gold standard for diagnosis of cardiac tumors. A fluorodeoxyglucose-labeled positron emission tomography (FGD-PET) scan can help to identify metabolically active lesions and, as such, is an effective tool for identifying malignant lesions (12) . The combination of PET and CT is superior to either alone and can help in disease staging and identifying distant metastases.…”

Section: Discussionmentioning

confidence: 99%

Left-Sided Intracardiac Tumors in a Case of Widespread Vulvar Cancer

2019

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Cardiac metastasis in uterine cervical cancer

Simek,

Sturdza,

Knoth

et al. 2024

Strahlenther Onkol

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Purpose Cardiac metastasis from cervical cancer is rare and only scarcely documented. We aim to present a new case and systematically summarize the available literature. Materials and methods PubMed, Scopus, Web of Science, Central, and ClinicalTrials.gov were systematically searched following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria. Results were screened via title, abstract, and full text. Additionally, the reference lists of all papers chosen for the review were screened. Results Eighty-one papers were identified, describing 86 cases in total. Cardiac metastasis occurred at all stages of cervical cancer and in all age groups. Median time from initial diagnosis to diagnosis of cardiac metastasis was 12 months. Patients mainly complained of dyspnea and chest pain, 60.8% had pathologic ECG (electrocardiographic) findings. The cardiac mass was most frequently detected by transthoracic echography. The most common tumor histology was squamous cell carcinoma. Chemotherapy and surgical interventions were the main treatment modalities. Median survival after diagnosis of cardiac metastasis was 3 months. Conclusion This largest review on cardiac metastases from cervical cancer confirmed the heart as a very infrequent site of metastasis. There are < 100 cases described in the literature, with very poor prognosis and undefined clinical management.

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Biventricular metastatic invasion from cervical squamous cell carcinoma

Cited by 5 publications

References 20 publications

A Rare Case of Cervical Cancer Metastasis to the Heart

A Rare Case of Cervical Cancer Metastasis to the Heart

Left-Sided Intracardiac Tumors in a Case of Widespread Vulvar Cancer

Cardiac metastasis in uterine cervical cancer

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