Bivalve molluscs as a unique target group for nanoparticle toxicity

Canesi, Laura; Ciacci, Caterina; Fabbri, Rita; Marcomini, Antonio; Pojana, Giulio; Gallo, Gabriella

doi:10.1016/j.marenvres.2011.06.005

Cited by 390 publications

(251 citation statements)

References 41 publications

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“…This was reflected in low measured Ti concentrations in the water column compared to the nominal concentrations. This is in accordance with previous studies that showed the aggregation of uncoated ENPs in environments with higher ionic strength, and aggregates formed by uncoated TiO2NP are assumed to be highly bioavailable for filter feeding organisms such as M. edulis (Canesi et al, 2012;Christian et al, 2008).…”

Section: Discussionsupporting

confidence: 93%

“…They are suspension feeders and are therefore highly specialized in the cellular internalization of micro-and nano-scale particles. As a consequence they are particularly susceptible to ENP exposure (Canesi et al, 2012). Previous in vivo and in vitro studies have reported adverse effects of TiO2NP on immune system and digestive gland function of M. galloprovincialis (Barmo et al, 2013;Canesi et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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The impact of TiO2 nanoparticles on uptake and toxicity of benzo(a)pyrene in the blue mussel (Mytilus edulis)

Farkas

Bergum

Nilsen

et al. 2015

Science of The Total Environment

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Nanoparticles are emerging contaminants of concern. Knowledge on their environmental impacts is scarce, especially on their interactive effects with other contaminants. In this study we investigated effects of titanium dioxide nanoparticles (TiO2NP) on the blue mussel (Mytilus edulis) and determined their influence on the bioavailability and toxicity of benzo(a)pyrene (B(a)P), a carcinogenic polyaromatic hydrocarbon (PAH). Blue mussels were exposed to either TiO2NP (0.2 and 2.0 mg L -1 ) or B(a)P (20 µg L -1 ) and to the respective combinations of these two compounds. Aqueous contaminant concentrations, the uptake of Ti and B(a)P into mussel soft tissue, effects on oxidative stress and chromosomal damage were analyzed. The uncoated TiO2NP agglomerated rapidly in the seawater. The presence of TiO2NP significantly reduced the bioavailability of B(a)P, shown by lowered B(a)P concentrations in exposure tanks and in mussel tissue. The activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were impacted by the various exposures regimes, indicating oxidative stress in the contaminant exposure groups. While SOD activity was increased only in the 0.2TiO2NP exposure group, CAT activity was enhanced in both combined exposure groups.The GPx activity was increased only in the groups exposed to the two single compounds. In hemocytes, increased chromosomal damage was detected in mussels exposed to the single compounds, which was further increased after exposure to the combination of compounds. In this study we show that the presence of TiO2NP in the exposure system reduced B(a)P uptake in blue mussels. However, since most biomarker responses did not decrease despite lower B(a)P uptake in combined exposures, the results suggest that TiO2NP can act as additional stressor, or potentially alters B(a)P toxicity by activation.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

The impact of TiO2 nanoparticles on uptake and toxicity of benzo(a)pyrene in the blue mussel (Mytilus edulis)

Farkas

Bergum

Nilsen

et al. 2015

Science of The Total Environment

View full text Add to dashboard Cite

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“…It is important to mention that the differences between the populations of mussels in their ability to accumulate trace metals were evident even after the depuration for 21 days in the tap water. Nevertheless, the same regularities for the mussels from the sites with different level of pollution were also detected in other studies [7] and could be explained by the remarkable accumulative properties of these organisms [2,4].…”

Section: Resultssupporting

confidence: 80%

“…Moreover, mussels are the main filtrators of surface water, including suspended particles. Therefore they are of particular interest for the study of the biological effect of engineering nanoparticles [4,10]. For the present study we selected the exposure to Zinc oxide nanoparticles (nZnO) that are widely utilized in electronics and personal care products and expected to reach nowadays the concentrations as high as micrograms per liter in the surface waters [5].…”

Section: Introductionmentioning

confidence: 99%

Biochemical responses of bivalve mollusk Unio tumidus to the effect of nanoform of zinc oxide depending on the thermal regime

et al. 2017

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Indigenous bivalve mollusks from the cooling reservoirs of thermoelectric power plants (TPPs) are subjected to constantly elevated temperature and industrial pollution. Therefore, they could be regarded as a suitable model organisms adapted to the combination of typical novel environmental challengers in their habitats. The aim of this study was to elucidate the bioavailability of novel pollutant -nanoform of Zinc oxide (nZnO) -in the mollusks from TPPs depending on the temperature of exposure. The metal accumulation and molecular responses of stress were investigated in the Unio tumidus (Unionidae) mollusks from two cooling reservoirs of TPPs (D-and B-groups) under the exposures to Zinc ions (3.1 µM), nZnO (3.1 µM) at 18 °C, elevated temperature (25 °C), and nZnO at 25 °C during 14 days. In most of the experimental groups, a selective increase of metal accumulation in metallothioneins in comparison with the tissue level, up-regulation of cytochrome c level, and the decrease of oxyradical generation were detected in the digestive gland. In the gills, the increased DNA fragmentation was found. Under the 25 °C, the level of glutathione in the tissues was depleted. B-groups were distinguished by down-regulation of cholinesterase activity and increased level of cadmium in tissues. Thus, the biochemical responses of mussels from the cooling reservoirs reflect the lack of specific mechanisms of detoxification and preva lence of the nonspecific responses of stress. In the BPP-groups, the signs of toxicity indicate higher level of pollution in the reservoir.

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“…Consequently, they can be used as an indicator for the accumulation of significant amounts of nanoparticles exposed to the environment (Canesi et al 2012). Bivalves are considered as a sensitive indicator to chemical pollution (Fournier et al 2001) because these organisms are in direct contact with contaminants in water and sediments and store high levels of contaminants in their organs (Farris and Hassel 2007).…”

Section: Introductionmentioning

confidence: 99%

Investigation of sub-acute levels of zinc oxide nanoparticles on the filtration rate of Mytilaster lineatus and Dressina polymorpha in the short term

et al. 2018

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Abstract. Qadermarzi A, Pouladi M, Rezamand A, Hoseinifar SH, Hedayati AA. 2018. Investigation of sub-acute levels of zinc oxide nanoparticles on the filtration rate of Mytilaster lineatus and Dressina polymorpha in the short term. Nusantara Bioscience 10: 53-57. The filtration rate is one of the physiological indices in the bivalves which indicate the degree of efficacy of the filtration function in the exposure to contaminants. In this study, changes in the filtration rate of freshwater bivalves (D. polymorpha and M. lineatus) were investigated after exposure periods of 5 and 10 days with nanoparticles. Bivalves were transferred from the natural environment to the laboratory. The distribution of nanoparticles was measured by differential light scattering (DLS). Bivalves were exposed to 2.5, 25 and 50 ppm nanoparticles for ten days in water reservoirs. The filtration rates were significantly different in the treatments compared to the control samples, with the highest filtration rate was observed in the control group. On the fifth day, the highest filtration rate was obtained in the first treatment of M. lineatus and the lowest filtration rate was obtained in the third treatment of D. polymorphia. The highest filtration rates were observed in the first and second treatments and the lowest filtration rate was observed in the third treatment. Also, there was no significant difference in the filtration rate of M. lineatus in the 1 st treatment with control (P> 0.05) on the 5 th day, but filtration rate was significantly (P <0.05) less than other concentrations and control group in the third treatment. On the other hand, the filtration rates on the 10 th day showed similar differences compared to the 5 th day. It could be concluded that the changes infiltration rate are an appropriate indicator for the measurement of contamination in nanoparticles.

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Bivalve molluscs as a unique target group for nanoparticle toxicity

Cited by 390 publications

References 41 publications

The impact of TiO2 nanoparticles on uptake and toxicity of benzo(a)pyrene in the blue mussel (Mytilus edulis)

The impact of TiO2 nanoparticles on uptake and toxicity of benzo(a)pyrene in the blue mussel (Mytilus edulis)

Biochemical responses of bivalve mollusk Unio tumidus to the effect of nanoform of zinc oxide depending on the thermal regime

Investigation of sub-acute levels of zinc oxide nanoparticles on the filtration rate of Mytilaster lineatus and Dressina polymorpha in the short term

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