Bivalent Ligand Containing Curcumin and Cholesterol as a Fluorescence Probe for Aβ Plaques in Alzheimer’s Disease

Li, Kai; Guo, Tai L.; Chojnacki, Jeremy E.; Lee, Hyoung Gon; Wang, Xinglong; Siedlak, Sandra L.; Rao, Wei; Zhu, Xiongwei; Zhang, Shijun

doi:10.1021/cn200122j

Cited by 70 publications

(48 citation statements)

References 30 publications

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“…However, there have been fewer reports regarding the development of fluorescent probes than PET probes despite their significance, although AOI-987, 29 NIAD-4, 30 CRANAD-2, 32 ANCA-11, 35 and BMAOI 36 have been reported for the imaging of Aβ plaques.…”

mentioning

confidence: 99%

BODIPY-Based Molecular Probe for Imaging of Cerebral β-Amyloid Plaques

Ono

Watanabe

Kimura

et al. 2012

ACS Chem. Neurosci.

139

114

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We designed and synthesized a BODIPY-based probe (BAP-1) for the imaging of β-amyloid plaques in the brain. In binding experiments in vitro, BAP-1 showed excellent affinity for synthetic Aβ aggregates. β-Amyloid plaques in Tg2576 mouse brain were clearly visualized with BAP-1. In addition, the labeling of β-amyloid plaques was demonstrated in vivo in Tg2576 mice. These results suggest BAP-1 to be a useful fluorescent probe for the optical imaging of cerebral β-amyloid plaques in patients with Alzheimer's disease.

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mentioning

confidence: 99%

BODIPY-Based Molecular Probe for Imaging of Cerebral β-Amyloid Plaques

Ono

Watanabe

Kimura

et al. 2012

ACS Chem. Neurosci.

139

114

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“…Furthermore, 19 specifically bound to Aβ plaques in both AD human patients and Aβ precursor proteins from transgenic mouse brain tissues. Interestingly, although 19 has a molecular weight of more than 1000 Da, it could in fact rapidly cross the BBB, reach the brain tissue and become metabolized in a reasonable time window (~3 h), suggesting amenability in clinical applications [69] . This result suggests that cholesterol could be used as a promoting unit when a probe lacks BBB permeability.…”

Section: Derivatives Of Stilbenementioning

confidence: 99%

Advances in development of fluorescent probes for detecting amyloid-β aggregates

Ren

Tang

et al. 2016

Acta Pharmacol Sin

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With accumulating evidence suggesting that amyloid-β (Aβ) deposition is a good diagnostic biomarker for Alzheimer's disease (AD), the discovery of active Aβ probes has become an active area of research. Among the existing imaging methods, optical imaging targeting Aβ aggregates (fibrils or oligomers), especially using near-infrared (NIR) fluorescent probes, is increasingly recognized as a promising approach for the early diagnosis of AD due to its real time detection, low cost, lack of radioactive exposure and high-resolution. In the past decade, a variety of fluorescent probes have been developed and tested for efficiency in vitro, and several probes have shown efficacy in AD transgenic mice. This review classifies these representative probes based on their chemical structures and functional modes (dominant solvent-dependent mode and a novel solvent-independent mode). Moreover, the pharmaceutical characteristics of these representative probes are summarized and discussed. This review provides important perspectives for the future development of novel NIR Aβ diagnostic probes.

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“…In this probe, curcumin was used as the Aβ recognition moiety and cholesterol as an anchor to the neuronal cell membrane–lipid rafts. Their results indicated that BMAOI 14 bound to the Aβ monomers, oligomers, and fibrils with low micromolar to submicromolar binding affinities [88]. …”

Section: Amyloid-βmentioning

confidence: 99%

Dual Functional Small Molecule Probes as Fluorophore and Ligand for Misfolding Proteins

Zhang¹,

Ran²

2013

COC

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Misfolding of a protein is a destructive process for variety of diseases that include neurodegenerative diseases such as Alzheimer’s disease, Parkinson disease, Huntington disease, mad cow disease, amyotrophic lateral sclerosis (ALS), and frontal temporal dementia (FTD), and other non-CNS diseases such as diabetes, cystic fibrosis, and lysosomal storage diseases. Formation of various misfunctional large assembles of the misfolded protein is the primary consequence. To detect the formation of the aggregated species is very important for not only basic mechanism research but also very crucial for diagnosis of the diseases. In this review, we updated references related to the new development of the dual functional fluorescent small molecule probes for detecting the aggregated proteins in vitro and in vivo.

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Bivalent Ligand Containing Curcumin and Cholesterol as a Fluorescence Probe for Aβ Plaques in Alzheimer’s Disease

Cited by 70 publications

References 30 publications

BODIPY-Based Molecular Probe for Imaging of Cerebral β-Amyloid Plaques

BODIPY-Based Molecular Probe for Imaging of Cerebral β-Amyloid Plaques

Advances in development of fluorescent probes for detecting amyloid-β aggregates

Dual Functional Small Molecule Probes as Fluorophore and Ligand for Misfolding Proteins

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