Bitter perception is altered in asthma and predicts its severity

Bogdanov, V; Herzog, Michael; Kazopoulos, T; Grafmans, Daniel; Zhu, Yunmeng; Hummel, Thomas

doi:10.1016/j.jaci.2020.03.010

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…Recently, Aries-Guillen et al reported that children with asthma had changes in taste and eating behaviors compared to controls [ 63 ], with asthmatic children requiring more time and a higher number of masticatory cycles to finish food, higher concentration to perceive taste, and higher frequency of feeding difficulties. This may be linked to the known impaired sense of smell and altered taste perception in asthmatic individuals [ 64 , 65 , 66 , 67 ] related in part to a decrease in expression of olfactory and taste receptors in asthma [ 68 , 69 ]. Intriguingly, olfactory and taste receptors are also found in non-sensory tissues and cells, including the lung [ 70 ] and gut [ 71 , 72 ].…”

Section: Discussionmentioning

confidence: 99%

Resting Energy Expenditure Is Elevated in Asthma

et al. 2021

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Background: Asthma physiology affects respiratory function and inflammation, factors that may contribute to elevated resting energy expenditure (REE) and altered body composition. Objective: We hypothesized that asthma would present with elevated REE compared to weight-matched healthy controls. Methods: Adults with asthma (n = 41) and healthy controls (n = 20) underwent indirect calorimetry to measure REE, dual-energy X-ray absorptiometry (DEXA) to measure body composition, and 3-day diet records. Clinical assessments included spirometry, fractional exhaled nitric oxide (FENO), and a complete blood count. Results: Asthmatics had greater REE than controls amounting to an increase of ~100 kcals/day, even though body mass index (BMI) and body composition were similar between groups. Inclusion of asthma status and FENO in validated REE prediction equations led to improved estimates. Further, asthmatics had higher white blood cell (control vs. asthma (mean ± SD): 4.7 ± 1.1 vs. 5.9 ± 1.6, p < 0.01) and neutrophil (2.8 ± 0.9 vs. 3.6 ± 1.4, p = 0.02) counts that correlated with REE (both p < 0.01). Interestingly, despite higher REE, asthmatics reported consuming fewer calories (25.1 ± 7.5 vs. 20.3 ± 6.0 kcals/kg/day, p < 0.01) and carbohydrates than controls. Conclusion: REE is elevated in adults with mild asthma, suggesting there is an association between REE and the pathophysiology of asthma.

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Section: Discussionmentioning

confidence: 99%

Resting Energy Expenditure Is Elevated in Asthma

et al. 2021

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“…They reported that taste recognition ability was decreased for all the basic tastes in adolescent and adult patients with allergic rhinitis. In a recent clinical prospective study by Bogadanov et al [182], PROP responsiveness was evaluated in adult patients with asthma. Noteworthy, bitter and overall taste sensitivity decreased with increasing of asthma severity.…”

Section: Chemo-sensory Perception In Patients With Respiratory Allergic Diseasesmentioning

confidence: 99%

The Influence of Common Noncommunicable Diseases on Chemosensory Perception and Clinical Implications in Children and Adolescents

Cattaneo

Mameli

D’Auria

et al. 2022

Advances in Nutrition

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An increased incidence of noninfectious chronic diseases, such as obesity, diabetes, and allergies, has been noted in the last century, especially in the last 2 to 3 generations. Evidence suggested that the interrelation among these chronic conditions in pediatric age (e.g., children and adolescents aged 4–16 y) is complex and still unknown, reinforcing the interest of pediatricians in these diseases. Of interest is the need to better understand the link between these pathologies and sensory perception, since the chemical senses of taste and smell, together with chemesthesis, are reported to have a role in food choices and may provide a novel target for intervention in the treatment of these pathologies. This review aims to explore the current evidence on the link between these chronic conditions and chemosensory perception (i.e., taste and smell). In addition, the putative role that chemosensory perception may have on food choices and eating behavior of children and adolescents affected by these diseases are highlighted. Furthermore, the review addresses the unexplored issues that need to be investigated in this area. The literature data search suggested that no clear relation between taste and smell perception and the aforementioned diseases in young population yet exists. However, some possible trends have been highlighted in the adult population, in whom the duration of disease might have affected the relation. There is a need for further, high-quality, hypothesis-led research, with robust measures of taste and smell functions as the primary outcomes, to strengthen or deny this evidence.

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Bitter perception is altered in asthma and predicts its severity

Cited by 2 publications

References 4 publications

Resting Energy Expenditure Is Elevated in Asthma

Resting Energy Expenditure Is Elevated in Asthma

The Influence of Common Noncommunicable Diseases on Chemosensory Perception and Clinical Implications in Children and Adolescents

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