The aim of our work – to establish the effectiveness of the improved method of treatmentof acute odontogenic periostitis in children suffering from diffuse non-toxic goiter.Materials and methods. 38 children aged 12-15 years with acute odontogenic periostitisagainst a background of diffuse non-toxic goiter were involved into the treatment andobservation. Pharmacological correction was applied in the complex of generallyaccepted treatment measures, in particular, the appointment of topical probiotic lozengesfor absorption «BioGaia Prodentis» and oral administration of the immunomodulatorydrug «Imupret» against a background of correction of the trace element supply of thechild’s body with the drug «Calcemin advance».The results. The high clinical effectiveness of the proposed method of treatment wasestablished, which was confirmed by the reduction of the treatment period to (5.3±0.26)days against (8.0±0.36) days with the generally accepted method of treatment (p<0.05)and the normalization of all protective components of oral fluid.Conclusion. The proposed method of treatment makes it possible to provide effectively thedental care to children with odontogenic inflammatory diseases, taking into account theetiopathogenetic mechanisms of the formation of the inflammatory process and preventingthe development of possible complications from the dento- maxillofacial system and thechild’s body as a whole.