Bitten by a bug or a bag? Transfusion‐transmitted dengue: a rare complication in the bleeding surgical patient

Oh, Han Boon; Muthu, Vaishnavi; Daruwalla, Zubin J; Lee, Shir Ying; Koay, Evelyn Siew Chuan; Tambyah, Paul A

doi:10.1111/trf.13054

Cited by 41 publications

(36 citation statements)

References 10 publications

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“…DENV is a part of the emerging risks of transfusion‐transmitted infections with the WNV and the Chikungunya virus (CHIKV) among others . Transmission of DENV through viraemic blood products is currently well documented . This risk is related to asymptomatic or subclinical cases.…”

Section: Discussionmentioning

confidence: 99%

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Seroprevalence and factors associated with IgG anti‐DENV positivity in blood donors in Burkina Faso during the 2016 dengue outbreak and implications for blood supply

Sawadogo

Baguiya

Yougbare

et al. 2019

Transfusion Medicine

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Summary Objectives Our study aimed to update the seroprevalence and factors associated with anti‐dengue virus (DENV) antibody positivity among blood donors and to discuss their implications for blood supply. Background Questions on the potential transmission of DENV by transfusion increased after the documentation of the risk of transmission of the West Nile virus. This risk was estimated after transfusion of DENV RNA‐positive blood units of up to 37.5%. In Burkina Faso, very few studies on DENV in blood donors have been conducted. As a result, there were no reliable data on DENV to allow the implementation of appropriate measures to control the risk of transmission of the dengue virus by blood transfusion. Methods We conducted a 4‐week cross‐sectional study from December 4 to 30, 2016. Blood donors of both genders, aged 18‐60 years, accepted for blood donation after medical selection were consecutively enrolled. Results Our study included a total of 1007 blood donors, in which donors living in urban areas represented 78.2%. The mean age was 26.1 ± 8.1 years. After adjustment in a multiple regression logistic model, the odds of having IgG anti‐DENV increased as age increased. The odds of DENV was 53% lower in rural areas (OR = 0.47; P = .000) compared to urban settings and 42% lower in mobile sites (OR = 0.58; P = .03) compared to fixed ones. Conclusion Our study provides new and useful insights for future research on the risk of TT‐DENV throughout blood transfusion.

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Section: Discussionmentioning

confidence: 99%

“…It seems highly probable that DENV is transmitted in a manner similar to the WNV as both are arboviruses within the same family of Flaviviridae . Many cases of DENV TT were documented in Hong Kong, in Singapore, in Puerto Rico and in Brazil . Sabino et al .…”

mentioning

confidence: 99%

Seroprevalence and factors associated with IgG anti‐DENV positivity in blood donors in Burkina Faso during the 2016 dengue outbreak and implications for blood supply

Sawadogo

Baguiya

Yougbare

et al. 2019

Transfusion Medicine

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“…DENV transfusion transmission has been documented in several locations worldwide including Hong Kong, Singapore, Puerto Rico, and Brazil . However, it is probable that there have been more, unreported cases.…”

mentioning

confidence: 99%

Dengue and chikungunya viruses in plasma are effectively inactivated after treatment with methylene blue and visible light

et al. 2016

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“…Therefore, the NS1 antigen enzyme‐linked immunosorbent assay is not expected to be effective and a much more sensitive nucleic acid test is urgently needed . Positively, TMA assays for DENV screening among blood donors are currently in advanced phase of validation, even though the US Food and Drug Administration has not approved the technique for routine blood screening as of today . However, when the test is approved, how to use it in a more cost‐effective way requires further assessment.…”

Section: Discussionmentioning

confidence: 99%

High estimated prevalence of asymptomatic dengue viremia in blood donors during a dengue epidemic in southern Taiwan, 2015

Chien¹,

Shu²,

Chuang

et al. 2017

Transfusion

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Although dengue is currently not endemic in Taiwan, physicians need to be aware of the risk of transfusion-transmitted DENV infection. Our results suggest that screening measures to ensure blood safety should be evaluated and implemented during dengue epidemics even in nonendemic areas. Timely estimation of daily asymptomatic viremia prevalence by districts can help to select high-risk areas for such measures and to evaluate cost-effectiveness.

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Bitten by a bug or a bag? Transfusion‐transmitted dengue: a rare complication in the bleeding surgical patient

Abstract: This case highlights the importance of arboviral screening of donor blood, especially for populations in endemic areas during outbreaks.

Cited by 41 publications

References 10 publications

Seroprevalence and factors associated with IgG anti‐DENV positivity in blood donors in Burkina Faso during the 2016 dengue outbreak and implications for blood supply

Seroprevalence and factors associated with IgG anti‐DENV positivity in blood donors in Burkina Faso during the 2016 dengue outbreak and implications for blood supply

Dengue and chikungunya viruses in plasma are effectively inactivated after treatment with methylene blue and visible light

High estimated prevalence of asymptomatic dengue viremia in blood donors during a dengue epidemic in southern Taiwan, 2015

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