While it is known that one can consider the Cauchy problem for evolution equations with Caputo derivatives, the situation for the initial value problems for the Riemann-Liouville derivatives is less understood. In this paper we propose new type initial, inner and inner-boundary value problems for fractional differential equations with the Riemann-Liouville derivatives. The results on the existence and uniqueness are proved, and conditions on the solvability are found. The wellposedness of the new type initial, inner and inner-boundary conditions are also discussed. Moreover, we give explicit formulas for the solutions. As an application fractional partial differential equations for general positive operators are studied. Contents 1. Introduction 1 2. Cauchy type problems 4 2.1. Generalized initial (Cauchy) problem 5 2.2. Partial differential equations with the Cauchy type data 9 3. Inner value problem 12 3.1. Partial differential equations with the non-local Cauchy type data 14 4. Inner-boundary value problem 15 4.1. Inner-boundary value problem for time-fractional partial differential equations 16 References 17