Bisset v Wilkinson [1927] AC 177, Privy Council

Abstract

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Bisset v Wilkinson [1927] AC 177, Privy Council. The document also includes supporting commentary from author Nicola Jackson.

Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N-Methyl-d-aspartate (NMDA), α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA), and Kainate Receptors

“…TARPs belong to claudin protein family and include several subtypes, including type I TARPs (γ2, γ3, γ4 and γ8), type II TARPs (γ5 and γ7), and other candidate AMPAR auxiliary proteins. 144 Among them, TARP γ-8 is highly expressed in the hippocampus but very low in the cerebellum, and acts as an exciting target in the treatment of pathologic disorders featured by hyperactivity within forebrain. 145 In 2016, several TARP γ-8 dependent antagonists were developed, and among them, JNJ-55511118 (K i = 26 nM in [ 3 H]JNJ-56022486 assay with rat hippocampus membranes) 146 and LY3130481 147 (65 and 66, respectively, Figure 6) displayed promising pharmacokinetic properties.…”

“…Moreover, TARP γ-2, the first discovered TARP member, is highly expressed in the cerebellum, where it plays a crucial role in the biological function of AMPARs in cerebellar granule neurons. 144 However, no γ-2-selective antagonist was reported to date. Furthermore, AMPAR PAMs show selectivity for AMPAR subpopulations of different subunit compositions.…”