Bisphosphonates in pregnancy and lactation-associated osteoporosis

O'Sullivan, Susannah; Grey, Andrew; Singh, Ruma G.; Reid, Ian R.

doi:10.1007/s00198-006-0112-3

Cited by 166 publications

(161 citation statements)

References 30 publications

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“…21 It is often associated with active osteoporotic changes and low BMD, 22,23 and therefore the phenomenon has been attributed to the presence of microfractures in the area.…”

Section: Clinical Features Of Bml Syndromesmentioning

confidence: 99%

Treatment of bone marrow lesions (bone marrow edema)

Eriksen

2015

BoneKEy Reports

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Bone marrow lesions (BMLs) or using older terminology 'Bone marrow edema' is characterised by excessive water signals in the marrow space on magnetic resonance imaging or ultrasound; BMLs constitute a central component of a wide variety of inflammatory and non-inflammatory rheumatologic conditions affecting the musculoskeletal system: BMLs are not only considered significant sources of pain but also linked to increased disease activity in many musculoskeletal conditions (for example, osteoarthritis, rheumatoid arthritis). The purpose of this review is to summarise current knowledge about the treatment of BMLs, with an emphasis on the clinical and histological features of this entity in inflammatory and non-inflammatory disease. We also try to pair this hypothesis with the apparent beneficial effects of various treatment regimens, mainly within the group of bone antiresorptive drugs (calcitonin, bisphosphonates) on symptoms associated with BMLs.

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“…21 It is often associated with active osteoporotic changes and low BMD, 22,23 and therefore the phenomenon has been attributed to the presence of microfractures in the area.…”

Section: Clinical Features Of Bml Syndromesmentioning

confidence: 99%

Treatment of bone marrow lesions (bone marrow edema)

Eriksen

2015

BoneKEy Reports

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“…Bundan dolayı olayın osteopeni zemininde mi, yoksa osteoporoz zemininde mi olduğu net ayırt edilememektedir (12) ve GİO'nun, gebeliğin bir sonucu mu olduğu, yoksa gebelik öncesi düşük KMY ile mi ilişkili olduğu kesinleşmemiştir. Etiyolojisi belirsiz olsa da, birinci derece yakınında GİO varlığı, düşük VKİ, fiziksel inaktivite, kötü beslenme, yetersiz kalsiyum alımı ve sigara kullanımı gibi bazı risk faktörleri belirlenmiştir (6,13,14). Sekonder osteoporoz nedenlerinin varlığını da risk faktörleri arasında sayan yayınlar mevcuttur (10,12).…”

Section: Discussionunclassified

A Rare Cause of Low Back Pain in Pregnancy: Pregnancy Associated Osteoporosis

Yetişgin¹,

Dokumaci²,

Eren³

et al. 2016

Tod

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SummaryPregnancy associated osteoporosis is a rare entity seen at the third trimester of first pregnancy or early postpartum period. It does not recur frequently in the subsequent pregnancies; however, it might lead to various complications unless it is treated. In this paper, we presented a woman diagnosed with pregnancy-associated osteoporosis with back pain at the 6 th month of the pregnancy in order to discuss the points to be taken into consideration in the diagnosis/differential diagnosis and treatment options of pregnancy associated osteoporosis. Keywords: Pregnancy associated osteoporosis, pregnancy, lactation, low back pain Gebelikte Görülen Bel Ağrısının Nadir Bir Nedeni: Gebelikle İlişkili Osteoporoz A Rare Cause of Low Back Pain in Pregnancy: Pregnancy Associated OsteoporosisGebelikle ilişkili osteoporoz, genellikle ilk gebeliğin son trimesteri ile doğum sonrası ilk aylarda görülebilen nadir bir klinik durumdur. Sonraki gebeliklerde sıklıkla tekrarlamaz ve tedavi edilmezse birçok komplikasyona neden olabilir. Bu yazıda, gebeliğinin 6. ayında şiddetli bel ağrısı şikayeti başlayan ve gebelikle ilişkili osteoporoz tanısı konulan bir hasta sunularak, tanı/ayırıcı tanıda dikkat edilmesi gereken konular ile tedavi seçeneklerini tartıştık.

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“…Nutritional calcium and activated vitamin D3 14) are given to replenish calcium. If accelerated bone resorption continues, bisphosphonate treatment is needed 15) . However, it has been reported that bisphosphonate could be teratogenic for the embryo.…”

Section: Discussionmentioning

confidence: 99%

Four-Year Follow-Up of Pregnancy-Associated Osteoporosis: A Case Report

Takahashi

Arai

Kayama

et al. 2014

FJMS

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: A 22 -year -old woman presented with complaints of severe pain in a wide region of the thoracolumbar spine. She developed severe pain in the thoracolumbar spine region 2 months after her first delivery and was referred 1 month later. A lateral thoracic X -ray showed depressed degenerative vertebrae (T7, T9). One month after the initial examination, thoracic sagittal magnetic resonance imaging showed low intensity areas on T1 -weighted imaging and iso -high intensity areas on T2 -weighted imaging at T5, 7, 8, 9 and 11. Bone mineral density measured by ultrasound was low (%YAM 76%). The bone metabolic markers were high, suggesting accelerated osteoclast activity. These findings prompted a diagnosis of pregnancy -associated osteoporosis. She was asked to stop breastfeeding and to wear a lumbar brace, and treatment with nutritional calcium, activated vitamin D3, and risedronate sodium was started. Her low back pain almost disappeared after treatment. Bone metabolic markers showed normalization 8 months after the initial examination. Risedronate sodium was stopped 2 years and 2 months after the initial examination. Teriparatide treatment was started because her bone mineral density remained low ; however, the osteoblast marker P1NP was not increased 5 months after the start of teriparatide treatment.

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Bisphosphonates in pregnancy and lactation-associated osteoporosis

Cited by 166 publications

References 30 publications

Treatment of bone marrow lesions (bone marrow edema)

Treatment of bone marrow lesions (bone marrow edema)

A Rare Cause of Low Back Pain in Pregnancy: Pregnancy Associated Osteoporosis

Four-Year Follow-Up of Pregnancy-Associated Osteoporosis: A Case Report

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