Bisphosphonates in orthopedic applications

Bisphosphonates enhance bacterial adhesion and biofilm formation on bone hydroxyapatite

“…BPs have been quickly applied to prevent bone loss in osteoporosis, to treat bone dysplasia and metabolic bone diseases, and to improve the stability of endoprostheses (Charpulat et al, 2004;Drake et al, 2008;Graham and Russel, 2011;Wilkinson and Little, 2011). Some of the adverse effects of using BPs were known from the beginning, such as increased temperature, atrial fibrillation, irritation of the digestive tract, and toxic effects on the kidneys (Drake et al, 2008).…”

Bisphosphonate-modified biomaterials for drug delivery and bone tissue engineering

“…For example, although antiresorptive, BPs, when used as a coating material for prosthesis, may paradoxically increase the amount of bone adjacent to a metallic implant, leading to its better fixation [8]. This effect was explained by that osteoblasts are decoupled from osteoclasts and can work independently in the case of bone trauma [9].…”

Pharmacological diversity among drugs that inhibit bone resorption

“…There may be other potential applications of bisphosphonates in orthopaedics [114]. These include protection against loosening of prostheses [115], better integration of biomaterials and implants [116], improved healing in distraction osteogenesis, and conserving bone architecture in hips affected by Perthes disease or osteonecrosis [117].…”