Bisphosphonate Treatment Beyond 5 Years and Hip Fracture Risk in Older Women

Izano, Monika A.; Lo, Joan C.; Adams, Annette L.; Ettinger, Bruce; Ott, Susan M.; Chandra, Malini; Hui, Rita L.; Niu, Fang; Li, Bonnie H.; Neugebauer, Romain

doi:10.1001/jamanetworkopen.2020.25190

Cited by 13 publications

(16 citation statements)

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“…Another explanation of the lack of efficacy of bisphosphonates in this study comes from the short duration of bisphosphonate consumption (of 12 and 17 months in the persistence and adherence analyses, respectively) [31]. Indeed, the time to benefit (TTB) of bisphosphonates, defined as the estimated time it takes for a bisphosphonate treatment to become significantly effective in a group of patients, is relatively long.…”

Section: Discussionmentioning

confidence: 90%

Bisphosphonate Use and Hospitalization for Hip Fractures in Women: An Observational Population-Based Study in France

Bourrion

Souty

Fournier

et al. 2021

IJERPH

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Bisphosphonates are widely used in the treatment of women at risk of osteoporotic hip fracture; however, the overall effectiveness of bisphosphonates in the prevention of osteoporotic fractures has not been studied in real life. To investigate whether the use of bisphosphonates in women aged 50 years and over is associated with a decrease in hospitalization for osteoporotic hip fractures, a historical prospective cohort study was conducted between 2009 and 2016 from a permanent representative sample consisting of 1/97 of the French health insurance beneficiaries. Bisphosphonate use was defined according to medication persistence and adherence regarding bisphosphonate dispensations. The primary outcome was the hospitalization rate for osteoporotic hip fracture. Among the 81,268 women included, 2005 were exposed to bisphosphonates. The median time of bisphosphonate exposure was 12 (IQR, 3–29) and 17 (IQR, 5–42) months for the persistence and adherence definitions, respectively. Exposure to bisphosphonates was not associated with a decrease in hospitalization for hip fracture: weighted HRadherence = 0.66 (95% CI, 0.33 to 1.33); HRpersistance = 0.77 (95% CI, 0.38 to 1.57). In real life, bisphosphonate use does not appear to reduce hospitalization for hip fractures, as to date, it is probably prescribed as primary prevention and for a duration too short to be effective.

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Section: Discussionmentioning

confidence: 90%

Bisphosphonate Use and Hospitalization for Hip Fractures in Women: An Observational Population-Based Study in France

Bourrion

Souty

Fournier

et al. 2021

IJERPH

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“…In a recent retrospective study of 29,685 women who had taken bisphosphonates for 5 years, authors evaluated the impact of stopping therapy, continuing for 2 years, or continuing for 5 more years on hip fracture incidence. 5 There was no difference in hip fracture incidence for patients who continued for 5 more years, compared with patients who stopped after 5 years. However, hip fracture risk was lower in those who continued for only 2 additional years and then stopped.…”

Section: Optimal Duration Of Bisphosphonate Therapymentioning

confidence: 84%

Women’s health update: A literature review impacting primary care

Dolan

Merriam

Prifti

et al. 2022

CCJM

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“…We retrieved 3133 unique records, of which 200 were included in the review (Figure 1). All reasons for excluding records after full-text review are given in eAppendix 6 in Supplement 1.…”

Section: Resultsmentioning

confidence: 99%

Reporting of Observational Studies Explicitly Aiming to Emulate Randomized Trials

Hansford,

Cashin,

Jones

et al. 2023

JAMA Netw Open

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ImportanceObservational (nonexperimental) studies that aim to emulate a randomized trial (ie, the target trial) are increasingly informing medical and policy decision-making, but it is unclear how these studies are reported in the literature. Consistent reporting is essential for quality appraisal, evidence synthesis, and translation of evidence to policy and practice.ObjectiveTo assess the reporting of observational studies that explicitly aimed to emulate a target trial.Evidence ReviewWe searched Medline, Embase, PsycINFO, and Web of Science for observational studies published between March 2012 and October 2022 that explicitly aimed to emulate a target trial of a health or medical intervention. Two reviewers double-screened and -extracted data on study characteristics, key predefined components of the target trial protocol and its emulation (eligibility criteria, treatment strategies, treatment assignment, outcome[s], follow-up, causal contrast[s], and analysis plan), and other items related to the target trial emulation.FindingsA total of 200 studies that explicitly aimed to emulate a target trial were included. These studies included 26 subfields of medicine, and 168 (84%) were published from January 2020 to October 2022. The aim to emulate a target trial was explicit in 70 study titles (35%). Forty-three studies (22%) reported use of a published reporting guideline (eg, Strengthening the Reporting of Observational Studies in Epidemiology). Eighty-five studies (43%) did not describe all key items of how the target trial was emulated and 113 (57%) did not describe the protocol of the target trial and its emulation.Conclusion and RelevanceIn this systematic review of 200 studies that explicitly aimed to emulate a target trial, reporting of how the target trial was emulated was inconsistent. A reporting guideline for studies explicitly aiming to emulate a target trial may improve the reporting of the target trial protocols and other aspects of these emulation attempts.

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Bisphosphonate Treatment Beyond 5 Years and Hip Fracture Risk in Older Women

Cited by 13 publications

References 50 publications

Bisphosphonate Use and Hospitalization for Hip Fractures in Women: An Observational Population-Based Study in France

Bisphosphonate Use and Hospitalization for Hip Fractures in Women: An Observational Population-Based Study in France

Women’s health update: A literature review impacting primary care

Reporting of Observational Studies Explicitly Aiming to Emulate Randomized Trials

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