Bisphosphonate-related osteonecrosis of the jaws: legal liability from the perspective of the prescribing physician

Russo, Lucio Lo; Muzio, Lorenzo Lo; Buccelli, Claudio; Lorenzo, Pierpaolo Di

doi:10.1007/s00774-013-0489-y

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…The more commonly used anti-osteoporosis drugs are bisphosphonates (alendronate), receptor activator of nuclear factor-κB ligand inhibitors (denosumab), calcitonin, parathyroid hormone therapy, selective estrogen receptor modulators and others (3). However, bisphosphonate-associated osteonecrosis of the jaws and other potential non-skeletal effects including hypocalcemia and worsening of renal impairment, may affect the clinical choices (4,5). Traditional Chinese medicines (TCM) have been widely used to prevent bone disorders (6).…”

Section: Introductionmentioning

confidence: 99%

ERα and Wnt/β‑catenin signaling pathways are involved in angelicin‑dependent promotion of osteogenesis

Cui

Liu

et al. 2019

Mol Med Report

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Reports of the ameliorative effect of angelicin on sex hormone deficiency-induced osteoporosis have highlighted this compound as a candidate for the treatment of osteoporosis. However, the molecular mechanisms of action of angelicin on osteoblast differentiation have not been thoroughly researched. The aim of the present study was to evaluate the effect of angelicin on the proliferation, differentiation and mineralization of rat calvarial osteoblasts using a Cell Counting Kit-8, alkaline phosphatase activity and the expression of osteogenic genes and proteins. Treatment with angelicin promoted the proliferation, matrix mineralization and upregulation of osteogenic marker genes including collagen type I α 1 and bone γ-carboxyglutamate in fetal rat calvarial osteoblasts. Furthermore, angelicin promoted the expression of β-catenin and runt related transcription factor 2, which serve a vital role in the Wnt/β-catenin signaling pathway. Consistently, the osteogenic effect of angelicin was attenuated by the use of a Wnt inhibitor. Moreover, angelicin increased the expression of estrogen receptor α (ERα), which also serves a key role in osteoblast differentiation. Taken together, these results demonstrated that angelicin may promote osteoblast differentiation through activation of ERα and the Wnt/β-catenin signaling pathway.

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Section: Introductionmentioning

confidence: 99%

ERα and Wnt/β‑catenin signaling pathways are involved in angelicin‑dependent promotion of osteogenesis

Cui

Liu

et al. 2019

Mol Med Report

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“…The accusations of presumed professional liability may be related both to the diagnostic assessment phase where there is lack of or unsuitable therapeutic specialisation, and to the therapeutic phase where the damage is produced directly [ 4 , 5 ] ( Table 2 ).…”

Section: Introductionmentioning

confidence: 99%

Professional dental and oral surgery liability in Italy: a comparative analysis of the insurance products offered to health workers

et al. 2016

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AbstractIntroductionIn Italy there has been an increase in claims for damages for alleged medical malpractice. A study was therefore conducted that aimed at assessing the content of the coverage of insurance policy contracts offered to oral health professionals by the insurance market.Material and methodsThe sample analysed composed of 11 insurance policy contracts for professional dental liability offered from 2010 to 2015 by leading insurance companies operating in the Italian market.ResultsThe insurance products analysed are structured on the “claims made” clause. No policy contract examined covers the damage due to the failure to acquire consent for dental treatment and, in most cases, damage due to unsatisfactory outcomes of treatment of an aesthetic nature and the failure to respect regulatory obligations on privacy.DiscussionOn entering into a professional liability insurance policy contract, the dentist should pay particular attention to the period covered by the guarantee, the risks both covered and excluded, as well as the extent of the limit of liability and any possible fixed/percentage excess.ConclusionsWhen choosing a professional liability contract, a dentist should examine the risks in relation to the professional activity carried out before signing.

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Legal liability in bisphosphonate-related osteonecrosis of the jaw

et al. 2014

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Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is an adverse reaction that may occur in patients administered with bisphosphonates (BP). This condition can cause high morbidity and hinder quality of life. Its treatment is complex and often unsatisfactory, and prevention strategies may have limited effectiveness, if any. Thus, managing patients treated with BP may result in exposure of the practitioner to legal liability or malpractice claims: legal actions pursuant to BRONJ are reported to be underway on three continents. Nonetheless, the attribution of liability, if any, is a complex process requiring, on the basis of current knowledge, a robust and pragmatic approach to the facts, which must be identified from the point of view of the time, place and individuals involved. This means a comprehensive consideration of the sequence of actions from bisphosphonates prescription to BRONJ occurrence (as well as immediately after, and any action potentially related to its causation or worsening) is required in order to determine if a breach in informing, diagnosing, managing or referring the patient took place, as well as determining if the patient was compliant in attending to prescriptions and follow-up programmes.

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Bisphosphonate-related osteonecrosis of the jaws: legal liability from the perspective of the prescribing physician

Cited by 4 publications

References 13 publications

ERα and Wnt/β‑catenin signaling pathways are involved in angelicin‑dependent promotion of osteogenesis

ERα and Wnt/β‑catenin signaling pathways are involved in angelicin‑dependent promotion of osteogenesis

Professional dental and oral surgery liability in Italy: a comparative analysis of the insurance products offered to health workers

Legal liability in bisphosphonate-related osteonecrosis of the jaw

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