Bisphosphonate-related osteonecrosis of the jaws: Cohort study of surgical treatment results in seventy-four stage II/III patients

Pichardo, Sarina E.C.; Kuijpers, Sophie C.C.; Merkesteyn, J.P.R. van

doi:10.1016/j.jcms.2016.06.016

Cited by 28 publications

(29 citation statements)

References 26 publications

(38 reference statements)

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“…Bone resorption is a specific function of osteoclasts, which erode the bone surface; these cells are targeted by anti-osteoporosis therapy [ 6 ]. Bisphosphonates (BP) are clinically used in the treatment of osteoporosis and bone metastases [ 7 ]. BP has been reported in several cases with side effects such as gastrointestinal complaints, pyrexia and hypocalcemia, and especially bisphosphonate-related osteonecrosis of the jaw (BRONJ) which is a well-documented devastating caused by long-term use of BP [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Kaempferol-Inhibited Autophagy on Osteoclast Formation

Kim

Shin

Kim

et al. 2018

IJMS

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Kaempferol, a flavonoid compound, is derived from the rhizome of Kaempferia galanga L., which is used in traditional medicine in Asia. Autophagy has pleiotropic functions that are involved in cell growth, survival, nutrient supply under starvation, defense against pathogens, and antigen presentation. There are many studies dealing with the inhibitory effects of natural flavonoids in bone resorption. However, no studies have explained the relationship between the autophagic and inhibitory processes of osteoclastogenesis by natural flavonoids. The present study was undertaken to investigate the inhibitory effects of osteoclastogenesis through the autophagy inhibition process stimulated by kaempferol in murin macrophage (RAW 264.7) cells. The cytotoxic effect of Kaempferol was investigated by MTT assay. The osteoclast differentiation and autophagic process were confirmed via tartrate-resistant acid phosphatase (TRAP) staining, pit formation assay, western blot, and real-time PCR. Kaempferol controlled the expression of autophagy-related factors and in particular, it strongly inhibited the expression of p62/SQSTM1. In the western blot and real time-PCR analysis, when autophagy was suppressed with the application of 3-Methyladenine (3-MA) only, osteoclast and apoptosis related factors were not significantly affected. However, we found that after cells were treated with kaempferol, these factors inhibited autophagy and activated apoptosis. Therefore, we presume that kaempferol-inhibited autophagy activated apoptosis by degradation of p62/SQSTM1. Further study of the p62/SQSTM1 gene as a target in the autophagy mechanism, may help to delineate the potential role of kaempferol in the treatment of bone metabolism disorders.

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Section: Introductionmentioning

confidence: 99%

The Effects of Kaempferol-Inhibited Autophagy on Osteoclast Formation

Kim

Shin

Kim

et al. 2018

IJMS

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“…However, discontinuity of BP therapy, if possible, combined with surgical debridement to achieve clear and bleeding margins together with long-term antibiotic therapy administration is the treatment of choice. 13,15 In our series the only patient who was refractory to treatment was the only one who was currently on BP at time of BIONJ diagnosis. Li-Wan Lee suggested that for BRONJ lesions, surgical excision and curettage can obtain a better and faster results bone healing than conservative treatment.…”

Section: Discussionmentioning

confidence: 84%

Bisphosphonate Induced Osteonecrosis of the Jaws: Our Clinical Experience at King Hussein Medical Center, Amman, Jordan

Al-Rabadi¹,

Daklalah²,

Alwreikat³

et al. 2018

The Journal of Contemporary Dental Practice

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“…[32][33][34] Thus, in these Brazilian cases, the triggering factor most reported was tooth dental extraction (45.98%), especially in individuals using ZOE (62.50%). Tooth extraction was also reported to be the main local factor that triggered BRONJ in North American, 27 European 31,[34][35][36][37][38][39] and Asian [40][41][42][43] populations.…”

Section: Resultsmentioning

confidence: 99%