Bisphosphonate osteonecrosis of the jaw—a literature review of UK policies versus international policies on bisphosphonates, risk factors and prevention

Patel, Vinod; McLeod, Niall; Rogers, Simon N.; Brennan, Peter A.

doi:10.1016/j.bjoms.2010.05.007

Cited by 59 publications

(62 citation statements)

References 53 publications

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“…[19][20][21][22] Thus, treatment with BPs may help to reduce fibrous encapsulation and enhance implant osseointegration. However, since a number of recent studies have shown that systematic administration of BPs especially by intravenous injection may be associated with a severe bone disease, osteonecrosis of the jaws (ONJ), [23][24][25] development of strategies for local BP administration may be necessary to prevent this adverse effect.…”

mentioning

confidence: 99%

AnIn VitroAssessment of Fibroblast and Osteoblast Response to Alendronate-Modified Titanium and the Potential for Decreasing Fibrous Encapsulation

Neoh

Shi

et al. 2013

Tissue Engineering Part A

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Fibrous encapsulation can impair implant osseointegration and cause implant failure but currently there are limited strategies to address this problem. Since bisphosphonates (BPs), a class of drugs widely used to treat bone diseases, was recently found to induce fibroblast apoptosis, we hypothesize that by loading BPs on titanium (Ti) implant surface, fibrous encapsulation may be inhibited with simultaneous enhancement of implant osseointegration. This strategy of local administration can also be expected to minimize the adverse side effects of BPs, which are associated with intravenous injections. To verify this hypothesis, alendronate was loaded on Ti surface via a hydroxyapatite (CaP) coating, and the effects of the loaded alendronate on fibroblast proliferation and apoptosis, and osteoblast proliferation, alkaline phosphatase (ALP) activity, and apoptosis were investigated in vitro. With a surface density of loaded alendronate 0.046 mg/cm 2 or higher, fibroblast proliferation was suppressed due to increased apoptosis, while osteoblast proliferation and ALP activity increased with minimal apoptosis. In a coculture of fibroblasts and osteoblasts in a 1:1 ratio, *60% of the cells on these alendronate-loaded substrates were osteoblasts 1 day after cell seeding. The percentage of osteoblasts increased to about 75% 4 days after cell seeding. These results suggest that fibroblasts and osteoblasts respond differently toward the alendronate-modified substrates, and this phenomenon can potentially be capitalized to reduce fibrous encapsulation.

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mentioning

confidence: 99%

AnIn VitroAssessment of Fibroblast and Osteoblast Response to Alendronate-Modified Titanium and the Potential for Decreasing Fibrous Encapsulation

Neoh

Shi

et al. 2013

Tissue Engineering Part A

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“…Invasive treatments are not recommended. 1 Patients who are in the at-risk group should be informed about the possibility of developing BRONJ. They require regular control visits to check the state of the oral cavity, as well as preventive and conservative treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Such a procedure reduces the exposure of bone tissue to the flora of the oral cavity, which in turn supports the healing process without complications. 1 After the completion of a necrectomy, some authors suggest the covering of bone with platelet-rich plasma, which stimulates osteoblasts, accelerates epithelialization, reduces inflammation and stimulates angiogenesis. 23 A good result was obtained after the application of ozone combined with surgical treatments and antibiotic therapy.…”

Section: Discussionmentioning

confidence: 99%

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Bone necrosis associated with the use of bisphosphonates: Case report

Jachewicz¹,

Jakiel²

2017

Dent. Med. Probl.

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The aim of this study was to present the case of a 68-year-old female patient with jaw bone necrosis associated with the use of bisphosphonates. The case was qualified for the second degree of severity (BRONJ). The study demonstrates a multi-month observation of the patient and describes the sequestrectomy procedure performed, which was supplemented by covering the bone tissue with a collagen sponge. The treatment applied was slightly different from the accepted algorithms of proceedings. The difference was connected with the use of a collagen sponge containing gentamicin (used to cover the bone's surface) after the sequestrectomy. The collagen material, in contrast to the exposed dead bone, is a surface which may be susceptible to epithelization. This gives a possibility to the secondary closing of the wound as a result of granulation and epithelization without the bone's re-exposure. Moreover, the study characterizes indications for the use of bisphosphonates, their chemical structure and mechanism of action. It shows the definition of BRONJ (bisphosphonate-related osteonecrosis of the jaw) and risk factors for its occurrence, as well as prevention and treatment methods.

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“…Many authors suggest the use of perioperative antibiotics and a chlorhexidine mouthwash to reduce the risk of BRONJ development. Antimicrobial prophylaxis should be continued until mucosal seal over the wound is present 26 . Conflict of interest statement: The authors state that there are no conflicts of interest regarding the publication of this article.…”

Section: Discussionmentioning

confidence: 99%

Experience with the treatment of bisphosphonate-related osteonecrosis of the jaw

Janovska¹,

Mottl²,

Slezák³

2015

BIOMED PAP

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Bisphosphonate osteonecrosis of the jaw—a literature review of UK policies versus international policies on bisphosphonates, risk factors and prevention

Cited by 59 publications

References 53 publications

AnIn VitroAssessment of Fibroblast and Osteoblast Response to Alendronate-Modified Titanium and the Potential for Decreasing Fibrous Encapsulation

AnIn VitroAssessment of Fibroblast and Osteoblast Response to Alendronate-Modified Titanium and the Potential for Decreasing Fibrous Encapsulation

Bone necrosis associated with the use of bisphosphonates: Case report

Experience with the treatment of bisphosphonate-related osteonecrosis of the jaw

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