Bisphosphonate-incorporated coatings for orthopedic implants functionalization

Zhang, Jiaxin; Bai, Haotian; Bai, Miao; Wang, Xiaonan; Li, Zuhao; Xue, Hao; Wang, Jincheng; Cui, Yutao; Wang, Hong‐En; Wang, Yanbing; Zhou, Rongqi; Zhu, Xiujie; Xu, Min; Zhao, Xin; Liu, He

doi:10.1016/j.mtbio.2023.100737

Cited by 4 publications

(1 citation statement)

References 230 publications

(296 reference statements)

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“…7 As a result, BPs have been utilized to modify implants and develop local delivery systems for bone repair through methods such as chemical bonding, physical adsorption, covalent attachment or carrier systems. 8 Sandomierski et al 9 developed a risedronate delivery system by using calcium titanate to modify the titanium. And then risedronate was absorbed onto the surface of calcium titanate through chemical bonding.…”

Section: Introductionmentioning

confidence: 99%

Poloxamer 407 modified collagen/β-tricalcium phosphate scaffold for localized delivery of alendronate

Zhang,

Zhu,

Liang

et al. 2024

J Biomater Appl

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Systemic administration of alendronate is associated with various adverse reactions in clinical settings. To mitigate these side effects, poloxamer 407 (P-407) modified with cellulose was chosen to encapsulate alendronate. This drug-loaded system was then incorporated into a collagen/β-tricalcium phosphate (β-TCP) scaffold to create a localized drug delivery system. Nuclear magnetic resonance spectrum and rheological studies revealed hydrogen bonding between P-407 and cellulose as well as a competitive interaction with water that contributed to the delayed release of alendronate (ALN). Analysis of the degradation kinetics of P-407 and release kinetics of ALN indicated zero-order kinetics for the former and Fickian or quasi-Fickian diffusion for the latter. The addition of cellulose, particularly carboxymethyl cellulose (CMC), inhibited the degradation of P-407 and prolonged the release of ALN. The scaffold’s structure increased the contact area of P-407 with the PBS buffer, thereby, influencing the release rate of ALN. Finally, biocompatibility testing demonstrated that the drug delivery system exhibited favorable cytocompatibility and hemocompatibility. Collectively, these findings suggest that the drug delivery system holds promise for implantation and bone healing applications.

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Section: Introductionmentioning

confidence: 99%

Poloxamer 407 modified collagen/β-tricalcium phosphate scaffold for localized delivery of alendronate

Zhang,

Zhu,

Liang

et al. 2024

J Biomater Appl

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Bioinspired Hollow Mesoporous Silica Nanoparticles Coating on Titanium Alloy with Hierarchical Structure for Modulating Cellular Functions

Zhang,

Liu,

Wang

et al. 2024

J Bionic Eng

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Functions of Epimedin C in a zebrafish model of glucocorticoid‐induced osteoporosis

Zhou,

Lian,

Jia

et al. 2024

J Cellular Molecular Medi

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Epimedium is thought to enhance the integrity of tendons and bones, ease joint discomfort and rigidity and enhance kidney function. Although glucocorticoids are commonly used in clinical practice, the mechanism by which the active compound Epimedin C (EC) alleviates glucocorticoid‐induced osteoporosis (GIOP) is not well understood. The therapeutic potential of EC in treating GIOP was evaluated using alizarin red S staining, calcein immersion and fluorescence imaging, and bone mineralization, bone mass accumulation and bone density in zebrafish larvae were determined. Using the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, the key signalling pathways related to bone development were identified. A protein–protein interaction network (PPIN) was constructed to identify osteoclast characteristic genes and the findings were verified using real‐time quantitative PCR (RT‐qPCR). The bone tissue damage caused by prednisolone was reduced by EC. It also altered physiological processes, improved bone density, boosted mineralization and increased bone mass and activity. Subsequent empirical investigations showed that EC impacted the major signalling pathways involved in bone development, such as osteoclast differentiation, oestrogen, MAPK, insulin resistance, PPAR and AMPK signalling pathways. It also decreased the expression of genes typical of osteoclasts. The results of our study uncover a previously unknown function of EC in controlling bone formation and emphasize the potential of EC as a therapeutic target. The osteoprotective effect of EC indicates its potential as a cost‐effective strategy for treating GIOP.

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Bisphosphonate-incorporated coatings for orthopedic implants functionalization

Cited by 4 publications

References 230 publications

Poloxamer 407 modified collagen/β-tricalcium phosphate scaffold for localized delivery of alendronate

Poloxamer 407 modified collagen/β-tricalcium phosphate scaffold for localized delivery of alendronate

Bioinspired Hollow Mesoporous Silica Nanoparticles Coating on Titanium Alloy with Hierarchical Structure for Modulating Cellular Functions

Functions of Epimedin C in a zebrafish model of glucocorticoid‐induced osteoporosis

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