Bisphosphonate-based hydrogel mediates biomimetic negative feedback regulation of osteoclastic activity to promote bone regeneration

PgC3Mg metal–organic cages functionalized hydrogels with enhanced bioactive and ROS scavenging capabilities for accelerated bone regeneration

“…46 Since the inflammatory and bone remodelling environment after bone injury are often related to low pH, previous publications have demonstrated that the bioactive hydrogel contained bisphosphonate–Mg 2+ nanoparticles showing a fast Mg 2+ release in low acid environment than that in the physiological medium. 47 We therefore evaluated the Mg ion release at different pH values. Our results indicated that the GelMA/PgC 3 Mg gels showed similar Mg 2+ release profiles at both weak acid (pH 5) and base environment (pH 9) in comparison to that of the PBS conditions (Fig.…”

Effects of Zinc, Magnesium, and Iron Ions on Bone Tissue Engineering

“…Since overdosage of metal ions induces adverse effects on bone healing, it is of great importance to construct a suitable ion delivery system to control the release. Nanocomposite hydrogels have been demonstrated to be promising for the sustained and smart delivery of bioactive ions to enhance bone repair. ,,, Hydrogel is considered to have excellent biocompatibility, and molecules can easily be added to this material. Thanks to the fact that different dopants can cross-link with the hydrogel, the release speed of molecules are delayed.…”

Immunomodulatory Blood-Derived Hybrid Hydrogels as Multichannel Microenvironment Modulators for Augmented Bone Regeneration

“…Besides, the present i-PRF hybrid hydrogels can effectively promote osteogenic differentiation and proliferation of stem cells for bone regeneration, which also hold great potential to combine with other functional platforms such as drugs and stem cell delivery systems for enhanced tissue regeneration. 40,41 This study will facilitate the development of high-efficacy autologous platelet biomaterials by integrating the immunomodulatory activity to address the practical needs in tissue regeneration applications.…”