Bisphenol S induces brown adipose tissue whitening and aggravates diet-induced obesity in an estrogen-dependent manner

Wen, Xue; Xiao, Yang; Xiao, Haitao; Tan, Xueqin; Wu, Beiyi; Li, Zehua; Wang, Ru; Xu, Xuewen; Li, Tao

doi:10.1016/j.celrep.2023.113504

Cited by 5 publications

(3 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[79,80] Increased FA dependency in diabetic cardiomyopathy Disturbances in lipid metabolism are detected during the early stages of diabetes and cardiac diseases. [81,82] Circulating levels of FAs increase in both T1DM and T2DM [83,84] because of impaired insulin action in the lipolysis of adipose tissues and the liver. [85,86] In addition, the increase in circulating FAs suppresses glucose uptake and oxidation.…”

Section: Multiple Fates Of Glucose In Diabetic Cardiomyopathymentioning

confidence: 99%

Mitochondrial energy metabolism in diabetic cardiomyopathy: Physiological adaption, pathogenesis, and therapeutic targets

Ye,

Han,

Xie

et al. 2024

Chinese Medical Journal

Self Cite

View full text Add to dashboard Cite

Diabetic cardiomyopathy is defined as abnormal structure and function of the heart in the setting of diabetes, which could eventually develop heart failure and leads to the death of the patients. Although blood glucose control and medications to heart failure show beneficial effects on this disease, there is currently no specific treatment for diabetic cardiomyopathy. Over the past few decades, the pathophysiology of diabetic cardiomyopathy has been extensively studied, and an increasing number of studies pinpoint that impaired mitochondrial energy metabolism is a key mediator as well as a therapeutic target. In this review, we summarize the latest research in the field of diabetic cardiomyopathy, focusing on mitochondrial damage and adaptation, altered energy substrates, and potential therapeutic targets. A better understanding of the mitochondrial energy metabolism in diabetic cardiomyopathy may help to gain more mechanistic insights and generate more precise mitochondria-oriented therapies to treat this disease.

show abstract

Section: Multiple Fates Of Glucose In Diabetic Cardiomyopathymentioning

confidence: 99%

Mitochondrial energy metabolism in diabetic cardiomyopathy: Physiological adaption, pathogenesis, and therapeutic targets

Ye,

Han,

Xie

et al. 2024

Chinese Medical Journal

Self Cite

View full text Add to dashboard Cite

show abstract

“…Additionally, ER interacts with coactivator proteins to stimulate the activity of other transcription factors such as the AP-1 transcription factor subunit. 24 This crosssignalling between ERα and ERβ allows oestrogen to Figure 1 Oestrogen production and its effect on the uterine. (A) The production and catalysis of 17β-estradiol.…”

Section: The Oestrogen Pathway In Endometrial Cancermentioning

confidence: 99%

The role of oestrogen and oestrogen-calcium axis in endometrial carcinoma

Liu,

Wang,

Zhou

2024

gocm

View full text Add to dashboard Cite

Unopposed oestrogen is recognised as an inducer of endometrial cancer. Over the past 50 years, the effects of oestrogen on the endometrium and endometrial cancer have been a hot topic in the field of gynaecological oncology. In recent years, a series of studies by our team revealed that the non-genomic transcriptional effects of oestrogen can influence the progression of endometrial carcinoma by regulating calcium ions, suggesting that inhibiting calcium ion channel proteins could serve as an adjuvant therapy for endometrial cancer. In this review, we retrospectively summarise the sources of oestrogen in vivo, the effects of oestrogens on the uterus and endometrium, oestrogen signalling and the clinical application of oestrogen-related compounds, emphasising the significant role of oestrogen–calcium axis inhibition in adjuvant therapy for endometrial cancer.

show abstract

“…It has been reported that the presence of BPAF and BPS is associated with such metabolic disorders as gestational diabetes [ 195 ]. The evidence is clear that the xenoestrogenic activity of bisphenols leads to suppression of beige adipocyte formation, which is important for thermogenesis and energy expenditure [ 196 , 197 ]. By inhibiting the formation of beige adipocytes ( Figure 2 ), bisphenols disrupt the important metabolic function of beige adipose, contributing to weight gain and systemic metabolism.…”

Section: Disruption Of White-to-beige Transdifferentiationmentioning

confidence: 99%

White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming

Boychenko,

Egorova,

Brovin

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

Obesity has become a pandemic, as currently more than half a billion people worldwide are obese. The etiology of obesity is multifactorial, and combines a contribution of hereditary and behavioral factors, such as nutritional inadequacy, along with the influences of environment and reduced physical activity. Two types of adipose tissue widely known are white and brown. While white adipose tissue functions predominantly as a key energy storage, brown adipose tissue has a greater mass of mitochondria and expresses the uncoupling protein 1 (UCP1) gene, which allows thermogenesis and rapid catabolism. Even though white and brown adipocytes are of different origin, activation of the brown adipocyte differentiation program in white adipose tissue cells forces them to transdifferentiate into “beige” adipocytes, characterized by thermogenesis and intensive lipolysis. Nowadays, researchers in the field of small molecule medicinal chemistry and gene therapy are making efforts to develop new drugs that effectively overcome insulin resistance and counteract obesity. Here, we discuss various aspects of white-to-beige conversion, adipose tissue catabolic re-activation, and non-shivering thermogenesis.

show abstract

Bisphenol S induces brown adipose tissue whitening and aggravates diet-induced obesity in an estrogen-dependent manner

Cited by 5 publications

References 49 publications

Mitochondrial energy metabolism in diabetic cardiomyopathy: Physiological adaption, pathogenesis, and therapeutic targets

Mitochondrial energy metabolism in diabetic cardiomyopathy: Physiological adaption, pathogenesis, and therapeutic targets

The role of oestrogen and oestrogen-calcium axis in endometrial carcinoma

White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming

Contact Info

Product

Resources

About