Bisphenol S induced epigenetic and transcriptional changes in human breast cancer cell line MCF-7

Wei, Huang; Zhao, Chao; Zhong, Huan; Zhang, Shoudong; Xia, Yiji; Cai, Zongwei

doi:10.1016/j.envpol.2018.12.084

Cited by 54 publications

(34 citation statements)

References 70 publications

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“…THBS4 stimulates the proliferation of gastric cancer cells. The breast-related gene explored by Huang et al [32] contains the gene THBS4, which is up-regulated in breast cancer. In the study of hepatocellular carcinoma, Su et al [33] found that knockdown of ThBS4 inhibited migration and invasion of hepatocellular carcinoma cells, as well as hemangiocarcinoma-induced angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

Time series expression pattern of key genes reveals the molecular process of esophageal cancer

2020

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Correspondence: Yurong Sun (supiaoy66@163.com) Background: Esophageal cancer is one of the most poorly diagnosed and fatal cancers in the world. Although a series of studies on esophageal cancer have been reported, the molecular pathogenesis of the disease is still elusive. Aim: To investigate the molecular process of esophageal cancer comprehensively and deeply. Methods: Differential expression analysis was performed to identify differentially expressed genes (DEGs) in different stages of esophageal cancer. Then exacting gene interaction modules and hub genes were identified in module interaction network. Further, though survival analysis, methylation analysis, pivot analysis, and enrichment analysis, some important molecules and related function or pathway were identified to elucidate potential mechanism in esophageal cancer. Results: A total of 7457 DEGs and 14 gene interaction modules were identified. These module genes were significantly involved in the positive regulation of protein transport, gastric acid secretion, insulin-like growth factor receptor binding and other biological processes (BPs), as well as p53 signaling pathway, ERBB signaling pathway and epidermal growth factor receptor (EGFR) signaling pathway. Then, transcription factors (TFs) (including HIF1A) and ncRNAs (including CRNDE and hsa-mir-330-3p) significantly regulate dysfunction modules were identified. Further, survival analysis showed that GNGT2 was closely related to survival of esophageal cancer. And DEGs with strong methylation regulation ability were identified, including SST and SH3GL2. Conclusion: These works not only help us to reveal the potential regulatory factors in the development of disease, but also deepen our understanding of its deterioration mechanism.

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Section: Discussionmentioning

confidence: 99%

Time series expression pattern of key genes reveals the molecular process of esophageal cancer

2020

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“…Similar to BPS, this proliferative effect relies on cyclin D and E expression through ER-dependent pathways [39]. BPS, as shown for BPA, can also induce epigenetic and transcriptional changes in breast cancer cells, resulting in an increase in the expression of genes implicated in proliferation, cellular attachment as well as adhesion and migration [167]. Lastly, the bioavailability of BPS substitutes might be higher than for BPA.…”

Section: Discussionmentioning

confidence: 99%

A Potential New Mechanism for Bisphenol Molecules to Initiate Breast Cancer through Alteration of Bone Morphogenetic Protein Signaling in Stem Cells and Their Microenvironment

Guyot¹,

Maguer-Satta²

2020

Breast Cancer Biology

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Endocrine disruptors interfere with endocrine-mediated regulations of cell or organ functions. Estrogens are one of the main hormones altered by endocrine disruptors like bisphenol A (BPA). Stem cells are active from embryogenesis to late stages of adult life. Their unique properties, such as an extended lifespan and low cycling features, render these cell privileged targets of long-term exposure to numerous factors. Therefore, stem cells are likely to be affected following exposure to endocrine disruptors. One of the major signaling pathways involved in stem cell regulation is the bone morphogenetic protein (BMP) pathway. The BMP pathway is known for its involvement in numerous physiological and pathophysiological processes. Exposure of human mammary stem cells to pollutants such as BPA initiates fundamental changes in stem cells, in particular by altering major elements of BMP signaling, such as receptor expression and localization. Lastly, BPA and its substitute bisphenol S (BPS) have similar impacts on BMP signaling despite their different ER-binding properties, supporting the hypothesis that their biological effects cannot be extrapolated only from their interaction with ERα66. We review recent discoveries in this field and discuss their implications for cancer diagnosis, prevention, and treatment, as well as their relevance for studies on endocrine disruptors.

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“…Whereas treatment with 5-Aza-CdR facilitated the migration of MCF7 cells in a concentration-dependent manner, it was not clear why E-cadherin expression was decreased in MCF7 cells after 5-Aza-CdR treatment. To address this question, we analyzed the methylation status of CDH1 gene coding E-cadherin based on previous reports, and found that the CDH1 promoter region was mostly in a hypomethylation status in tumor specimens from breast cancer patients and MCF7 cells (Terada et al, 2009;Huang et al, 2019), suggesting that E-cadherin expression is not simply regulated by the methylation status of CDH1. It is thus crucial to consider that other pivotal genes might also be regulated after treatment of tumor cells with 5-Aza-CdR, besides the expression of SIPA1 and E-cadherin.…”

Section: -Aza-cdr Advances Emt In Mcf7 Cells Via Hypomethylation Of mentioning

confidence: 99%

5-Aza-2′-deoxycytidine advances the epithelial–mesenchymal transition of breast cancer cells by demethylating Sipa1 promoter-proximal elements

Wang

Wang‐Renault

et al. 2020

Journal of Cell Science

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Bisphenol S induced epigenetic and transcriptional changes in human breast cancer cell line MCF-7

Cited by 54 publications

References 70 publications

Time series expression pattern of key genes reveals the molecular process of esophageal cancer

Time series expression pattern of key genes reveals the molecular process of esophageal cancer

A Potential New Mechanism for Bisphenol Molecules to Initiate Breast Cancer through Alteration of Bone Morphogenetic Protein Signaling in Stem Cells and Their Microenvironment

5-Aza-2′-deoxycytidine advances the epithelial–mesenchymal transition of breast cancer cells by demethylating Sipa1 promoter-proximal elements

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