Bisphenol S alters development of the male mouse mammary gland and sensitizes it to a peripubertal estrogen challenge

Kolla, SriDurgaDevi; McSweeney, Danny; Pokharel, Aastha; Vandenberg, Laura N.

doi:10.1016/j.tox.2019.06.005

Cited by 19 publications

(6 citation statements)

References 59 publications

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“…Variations in exposure timing, dosage, and route of administration therefore make drawing conclusions about the effects of BPA on AGD difficult. Our results specifically conflict with a previous study examining perinatal BPS exposure, which found that perinatal BPS exposure alone was not sufficient to induce shortening of AGD ( Kolla et al, 2019 ). This difference may potentially be explained by the differences in timing of exposure, as the previous study began exposure at day 9 of pregnancy while exposure began at day 1 of pregnancy in the present report.…”

Section: Discussioncontrasting

confidence: 99%

Prenatal exposure to a low dose of BPS causes sex-dependent alterations to vascular endothelial function in adult offspring

Connors

Zhu²,

Gill³

et al. 2022

Front. Toxicol.

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Background: Bisphenol S (BPS) is among the most commonly used substitutes for Bisphenol A (BPA), an endocrine disrupting chemical used as a plasticizer in the manufacture of polycarbonate plastics and epoxy resins. Bisphenols interfere with estrogen receptor (ER) signaling, which modulates vascular function through stimulation of nitric oxide (NO) production via endothelial nitric oxide synthase (eNOS). BPS can cross into the placenta and accumulates in the fetal compartment to a greater extent than BPA, potentially interfering with key developmental events. Little is known regarding the developmental impact of exposure to BPA substitutes, particularly with respect to the vasculature.Objective: To determine if prenatal BPS exposure influences vascular health in adulthood.Methods: At the time of mating, female C57BL/6 dams were administered BPS (250 nM) or vehicle control in the drinking water, and exposure continued during lactation. At 12-week of age, mesenteric arteries were excised from male and female offspring and assessed for responses to an endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) vasodilator. Endothelium-dependent dilation was measured in the presence or absence of L-NAME, an eNOS inhibitor. To further explore the role of NO and ER signaling, wire myography was used to assess ACh responses in aortic rings after acute exposure to BPS in the presence or absence of L-NAME or an ER antagonist.Results: Increased ACh dilation and increased sensitivity to Phe were observed in microvessels from BPS-exposed females, while no changes were observed in male offspring. Differences in ACh-induced dilation between control or BPS-exposed females were eliminated with L-NAME. Increased dilatory responses to ACh after acute BPS exposure were observed in aortic rings from female mice only, and differences were eliminated with inhibition of eNOS or inhibition of ER.Conclusion: Prenatal BPS exposure leads to persistent changes in endothelium-dependent vascular function in a sex-specific manner that appears to be modulated by interaction of BPS with ER signaling.

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Section: Discussioncontrasting

confidence: 99%

Prenatal exposure to a low dose of BPS causes sex-dependent alterations to vascular endothelial function in adult offspring

Connors

Zhu²,

Gill³

et al. 2022

Front. Toxicol.

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“…Converging studies by Kolla et al published in 2018 and 2019, as well as by Catanese and Vandenberg published in 2017, were conducted by exposure via the oral route with at least two dose levels, and identified a common LOAEL of 2 µg/kg bw/day for mammary gland and neurobehavioral toxicity, respectively ( Table 3 ) [ 63 , 64 , 65 ]. This LOAEL has been selected as a POD for the derivation of the HBM-GVs.…”

Section: Resultsmentioning

confidence: 99%

Human Biomonitoring Guidance Values (HBM-GVs) for Bisphenol S and Assessment of the Risk Due to the Exposure to Bisphenols A and S, in Europe

Meslin

Beausoleil

Zeman

et al. 2022

Toxics

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Within the European Joint Programme HBM4EU, Human Biomonitoring Guidance Values (HBM-GVs) were derived for several prioritised substances. In this paper, the derivation of HBM-GVs for the general population (HBM-GVGenPop) and workers (HBM-GVworker) referring to bisphenol S (BPS) is presented. For the general population, this resulted in an estimation of the total urinary concentration of BPS of 1.0 µg/L assuming a 24 h continuous exposure to BPS. For workers, the modelling was refined in order to reflect continuous exposure during the working day, leading to a total urinary concentration of BPS of 3.0 µg/L. The usefulness for risk assessment of the HBM-GVs derived for BPS and bisphenol A (BPA) is illustrated. Risk Characterisation Ratios (RCRs) were calculated leading to a clear difference between risk assessments performed for both bisphenols, with a very low RCR regarding exposure to BPA., contrary to that obtained for BPS. This may be due to the endocrine mediated endpoints selected to derive the HBM-GVs for BPS, whereas the values calculated for BPA are based on the temporary Tolerable Daily Intake (t-TDI) from EFSA set in 2015. A comparison with the revised TDI recently opened for comments by EFSA is also discussed. Regarding the occupational field, results indicate that the risk from occupational exposure to both bisphenols cannot be disregarded.

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“…For many of the varied non-neuronal effects of bisphenols their structural similarity with estrogens is crucial 15 , 16 , 22 . A series of experiments was therefore aimed at exploring whether this might also apply, to some extent, to the strong neuronal effects we describe here.…”

Section: Resultsmentioning

confidence: 99%

Bisphenols exert detrimental effects on neuronal signaling in mature vertebrate brains

2021

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Bisphenols are important plasticizers currently in use and are released at rates of hundreds of tons each year into the biosphere1–3. However, for any bisphenol it is completely unknown if and how it affects the intact adult brain4–6, whose powerful homeostatic mechanisms could potentially compensate any effects bisphenols might have on isolated neurons. Here we analyzed the effects of one month of exposition to BPA or BPS on an identified neuron in the vertebrate brain, using intracellular in vivo recordings in the uniquely suited Mauthner neuron in goldfish. Our findings demonstrate an alarming and uncompensated in vivo impact of both BPA and BPS—at environmentally relevant concentrations—on essential communication functions of neurons in mature vertebrate brains and call for the rapid development of alternative plasticizers. The speed and resolution of the assay we present here could thereby be instrumental to accelerate the early testing phase of next-generation plasticizers.

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Bisphenol S alters development of the male mouse mammary gland and sensitizes it to a peripubertal estrogen challenge

Cited by 19 publications

References 59 publications

Prenatal exposure to a low dose of BPS causes sex-dependent alterations to vascular endothelial function in adult offspring

Prenatal exposure to a low dose of BPS causes sex-dependent alterations to vascular endothelial function in adult offspring

Human Biomonitoring Guidance Values (HBM-GVs) for Bisphenol S and Assessment of the Risk Due to the Exposure to Bisphenols A and S, in Europe

Bisphenols exert detrimental effects on neuronal signaling in mature vertebrate brains

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