Bisphenol A urinary level, its correlates, and association with cardiometabolic risks in Lebanese urban adults

Mouneimne, Youssef; Nasrallah, Mona; Khoueiry-Zgheib, Nathalie; Nasreddine, Lara; Nakhoul, Nancy; Ismail, Hussein; Abiad, Mohamad G.; Koleilat, Lynn; Tamim, Hani

doi:10.1007/s10661-017-6216-8

Cited by 49 publications

(59 citation statements)

References 40 publications

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“…A cross-sectional study conducted in the US showed that lower income was the most important predictor of exposure to BPA based on urine levels (21). In a study conducted in Greater Beirut, there was no significant correlation between BPA levels and income (14). However, all their participants had much lower incomes than our study participants, suggesting that our populations are different.…”

Section: Discussioncontrasting

confidence: 54%

“…In Greater Beirut, it was found that total BPA levels in urine are similar to the levels found in the rest of the world, suggesting a congruent exposure to BPA toxicity (14). In fact, drinking water purchased in polycarbonate containers was found to have detectable BPA levels in the products of 13 out of 22 companies sampled in Lebanon (15).…”

Section: Despite All the Evidence The Most Recent Risk Assessments Cmentioning

confidence: 78%

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Bisphenol A Toxicity: Familiarity, Knowledge, Attitude, and Practice Among University Students in Lebanon

Assi¹,

Labban²,

El-Dana³

et al. 2019

Preprint

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Background: In the absence of strict regulations, the extent of exposure to Bisphenol A (BPA) toxicity depends mainly on the consumers' own knowledge, attitude, and practices about the matter. The aim of this study was to assess the current level of familiarity and knowledge about BPA, attitude towards it, practices related to the use of BPA-containing products, and the predictors of each. Methods : We carried out a cross-sectional study among students at the American University of Beirut, Lebanon, between January and April 2017. Full-time students above the age of 18 and registered in a specific major were eligible to participate in the study. An English questionnaire that assesses familiarity, as well as knowledge, attitude, and practice (KAP) was developed based on current literature and expert opinion. Demographics, lifestyle, and level of familiarity with the topic were assessed among all participants. Predictors of familiarity, defined as knowing at least a little about BPA, were assessed among all participants using bivariate and multivariate analyses. Among students familiar with BPA, predictors of higher KAP scores were assessed by similar analyses. Adjusted odds ratios (OR) with 95% confidence interval (CI) were reported. Results : The level of familiarity with BPA was 23.7%.Studying in a health-related field was a predictor of familiarity (adjusted OR=3.11; CI: 2.08-4.66).

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Section: Discussioncontrasting

confidence: 54%

Section: Despite All the Evidence The Most Recent Risk Assessments Cmentioning

confidence: 78%

Bisphenol A Toxicity: Familiarity, Knowledge, Attitude, and Practice Among University Students in Lebanon

Assi¹,

Labban²,

El-Dana³

et al. 2019

Preprint

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“…Previously, BPA and phthalates have been linked to both impaired glucose metabolism 6,11,37,72,73 , as well as T2D 26,47,[73][74][75] . In this study, we did not find any significant associations between EDCs and glycaemic traits.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Endocrine Disrupting Chemicals in the Dutch general population is associated with adiposity-related traits

Meer

Faassen

Beek

et al. 2020

Sci Rep

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endocrine Disrupting chemicals (eDcs) have been linked to a variety of cardiometabolic diseases. Yet, few studies have investigated the exposure to eDcs and cardiometabolic health taking lifestyle into account. We aimed to assess exposure to five parabens, three bisphenols and thirteen metabolites of in total eight phthalates in a general Dutch population and to investigate their association with cardiometabolic traits. In 662 adult subjects from the population-based Lifelines cohort, 21 EDC analytes were measured in 24-hour urine collected in 2012, using LC-MS/MS. Association analyses between cardiometabolic traits and eDc concentrations were performed using multivariate linear models adjusting for age, sex, education, smoking, diabetes, physical activity and caloric intake. Quartile analyses were performed to assess linearity. Bisphenol A, four parabens and eight phthalate metabolites were detected in 84-100% of the samples. Adjusted associations for MiBP and MBzP and adiposity-related traits were robust for multiple testing (Beta's, BMI: 1.12, 2.52; waist circumference: 0.64, 1.56, respectively; FDR < 0.009). Associations for triglyceride, HDL-cholesterol, glucose and blood pressure were not. Linearity was confirmed for significant associations. Exposure to EDCs in the Dutch population is ubiquitous. We found direct associations between phthalates and adiposity-related traits. Prospective studies are needed to confirm these findings. During the past decades, cardiovascular diseases (CVD) and type 2 diabetes (T2D) have risen to epidemic proportions 1,2. These diseases are responsible for severe complications including myocardial infarction, stroke, blindness, lower limb amputation and renal failure, and are strongly correlated with a collection of asymptomatic cardiometabolic abnormalities such as (central) obesity, impaired glucose tolerance, elevated triglycerides, a low HDL-cholesterol, and hypertension 3,4. A combination of at least three of the above stated cardiovascular abnormalities defines the metabolic syndrome (MetS) 1. Risk factors include a combination of genetic predisposition and lifestyle (e.g. lack of physical activity, imbalanced diet). Meanwhile, a wide variety of synthetic chemicals have been introduced in our environment, some of which have been shown to cause metabolic disruptions in animal and human studies 5. Endocrine Disrupting Chemicals (EDCs) such as parabens, phenols and phthalates have been shown to be associated with the MetS 6,7 , obesity 8,9 and T2D 10,11. These EDCs have in common that they are widely used as preservatives and plasticizers and can therefore be found in a wide variety of consumer products. Exposure occurs through ingestion, inhalation, and dermal contact 12,13. Although parabens, phenols and phthalates have in common that they are metabolized and excreted fairly quickly (i.e. half-lives <24 h) and therefore are considered non-persistent 14-16 , exposure is ubiquitous throughout life and reported to be global 17-20. However, to date little is known about exposure...

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“…The study design and sampling strategy are published elsewhere [26][27][28]. In brief, a representative sample of Lebanese adults was recruited based on a multistage stratified probability sampling frame [29].…”

Section: Study Participantsmentioning

confidence: 99%

Dietary Glycemic Index and Glycemic Load Are Not Associated with the Metabolic Syndrome in Lebanese Healthy Adults: A Cross-Sectional Study

et al. 2020

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High dietary glycemic index (GI) and glycemic load (GL) were suggested to increase the risk of metabolic syndrome (MetS). This study aims to estimate dietary GI and GL in a sample of healthy Lebanese adults and examine their association with MetS and its individual abnormalities. The study uses data from a community-based survey of 501 Lebanese urban adults. Dietary intake was assessed using a food frequency questionnaire. Biochemical, anthropometric, and blood pressure measurements were obtained. Subjects with previous diagnosis of chronic disease, metabolic abnormalities, or with incomplete data or implausible energy intakes were excluded, yielding a sample of 283. Participants were grouped into quartiles of GI and GL. Multivariate logistic regression analyses were performed. Average dietary GI and GL were estimated at 59.9 ± 8 and 209.7 ± 100.3. Participants belonging to the highest GI quartile were at increased risk of having MetS (odds ratio (OR) = 2.251, 95% CI:1.120–4.525) but this association lost significance with further adjustments. Those belonging to the second quartile of GI had significantly lower odds of having hyperglycemia (OR: 0.380, 95% CI:0.174–0.833). No associations were detected between GL and MetS. The study contributes to the body of evidence discussing the relationship between GI, GL, and MetS, in a nutrition transition context.

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Bisphenol A urinary level, its correlates, and association with cardiometabolic risks in Lebanese urban adults

Cited by 49 publications

References 40 publications

Bisphenol A Toxicity: Familiarity, Knowledge, Attitude, and Practice Among University Students in Lebanon

Bisphenol A Toxicity: Familiarity, Knowledge, Attitude, and Practice Among University Students in Lebanon

Exposure to Endocrine Disrupting Chemicals in the Dutch general population is associated with adiposity-related traits

Dietary Glycemic Index and Glycemic Load Are Not Associated with the Metabolic Syndrome in Lebanese Healthy Adults: A Cross-Sectional Study

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