Bisphenol A release from short-term degraded resin-based dental materials

Nys, Siemon De; Duca, Radu Corneliu; Vervliet, Philippe; Boonen, Imke; Elskens, Marc; Vanoirbeek, Jeroen; Godderis, Lode; Meerbeek, Bart Van; Landuyt, Kirsten Van

doi:10.1016/j.jdent.2021.103894

Cited by 12 publications

(6 citation statements)

References 41 publications

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“…Any residue of resin deposited onto the buccal epithelium would eventually be swallowed due to salivary drainage 54 and the monomers or polymers might be decomposed due to the bacterial enzymes that are present in the oral cavity. 55 As we continue to advance this technology, these significant considerations will guide our efforts toward its practical and accessible implementation. In summary, the utilization of MN devices holds great promise for buccal drug administration, offering convenient application and disposal while facilitating rapid absorption of active substances.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Additional clinical trials should take place to examine the monomer and polymer clearance. Any residue of resin deposited onto the buccal epithelium would eventually be swallowed due to salivary drainage and the monomers or polymers might be decomposed due to the bacterial enzymes that are present in the oral cavity . As we continue to advance this technology, these significant considerations will guide our efforts toward its practical and accessible implementation.…”

Section: Discussionmentioning

confidence: 99%

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Fabrication of 3D Printed Hollow Microneedles by Digital Light Processing for the Buccal Delivery of Actives

Monou,

Andriotis,

Tsongas

et al. 2023

ACS Biomater. Sci. Eng.

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In the present study, two different microneedle devices were produced using digital light processing (DLP). These devices hold promise as drug delivery systems to the buccal tissue as they increase the permeability of actives with molecular weights between 600 and 4000 Da. The attached reservoirs were designed and printed along with the arrays as a whole device. Light microscopy was used to quality control the printability of the designs, confirming that the actual dimensions are in agreement with the digital design. Non-destructive volume imaging by means of microfocus computed tomography was employed for dimensional and defect characterization of the DLP-printed devices, demonstrating the actual volumes of the reservoirs and the malformations that occurred during printing. The penetration test and finite element analysis showed that the maximum stress experienced by the needles during the insertion process (10 N) was below their ultimate compressive strength (240–310 N). Permeation studies showed the increased permeability of three model drugs when delivered with the MN devices. Size-exclusion chromatography validated the stability of all the actives throughout the permeability tests. The safety of these printed devices for buccal administration was confirmed by histological evaluation and cell viability studies using the TR146 cell line, which indicated no toxic effects.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fabrication of 3D Printed Hollow Microneedles by Digital Light Processing for the Buccal Delivery of Actives

Monou,

Andriotis,

Tsongas

et al. 2023

ACS Biomater. Sci. Eng.

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“…Residual bisphenol A may remain from the synthesis process of these monomers, and thus trace amounts may be present as a contaminant in dental resins. 13 Currently, composite materials are considered low risk. Components of composite resins can be released during polymerisation and degradation of the material.…”

Section: Dental Restoration Materialsmentioning

confidence: 99%

Sustainability in dentistry part II: Sustainability and the use of chemicals in dentistry

Armstrong,

Dalton,

Croke

et al. 2024

Journal of the Irish Dental Association

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The world is now in an existential ecological crisis. Our deleterious and unsustainable impact on the planet has, among other things, increased greenhouse gas emissions, with further injury from plastics and other waste in the environment. The evidence for an accelerating biodiversity crisis and serious soil degradation in many parts of the world is irrefutable. The pandemic risk to our species and our planet is not if, but when. We have to change the way we organise society in order to make the future sustainable for all species. Worldwide health systems are a significant contributor to environmental damage. The first article in this series discussed general aspects of sustainability in general practice, and this second article examines the use of chemicals in practice.

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“…dental sealants, and medical devices [3,[16][17][18], as well as in micro/nanoplastics which are emerging environmental pollutants in water, land, air, and groundwater environments [19]. BPA exposure can occur through ingestion, absorption through the skin, and inhalation [20][21][22] and can circulate throughout the body [23].…”

Section: Highlightsmentioning

confidence: 99%

Sex-specific impacts of prenatal bisphenol A exposure on genes associated with cortical development, social behaviors, and autism in the offspring’s prefrontal cortex

Kanlayaprasit,

Saeliw,

Thongkorn

et al. 2024

Biol Sex Differ

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Background Recent studies have shown that prenatal BPA exposure altered the transcriptome profiles of autism-related genes in the offspring’s hippocampus, disrupting hippocampal neuritogenesis and causing male-specific deficits in learning. However, the sex differences in the effects of prenatal BPA exposure on the developing prefrontal cortex, which is another brain region highly implicated in autism spectrum disorder (ASD), have not been investigated. Methods We obtained transcriptome data from RNA sequencing analysis of the prefrontal cortex of male and female rat pups prenatally exposed to BPA or control and reanalyzed. BPA-responsive genes associated with cortical development and social behaviors were selected for confirmation by qRT-PCR analysis. Neuritogenesis of primary cells from the prefrontal cortex of pups prenatally exposed to BPA or control was examined. The social behaviors of the pups were assessed using the two-trial and three-chamber tests. The male-specific impact of the downregulation of a selected BPA-responsive gene (i.e., Sema5a) on cortical development in vivo was interrogated using siRNA-mediated knockdown by an in utero electroporation technique. Results Genes disrupted by prenatal BPA exposure were associated with ASD and showed sex-specific dysregulation. Sema5a and Slc9a9, which were involved in neuritogenesis and social behaviors, were downregulated only in males, while Anxa2 and Junb, which were also linked to neuritogenesis and social behaviors, were suppressed only in females. Neuritogenesis was increased in males and showed a strong inverse correlation with Sema5a and Slc9a9 expression levels, whereas, in the females, neuritogenesis was decreased and correlated with Anxa2 and Junb levels. The siRNA-mediated knockdown of Sema5a in males also impaired cortical development in utero. Consistent with Anxa2 and Junb downregulations, deficits in social novelty were observed only in female offspring but not in males. Conclusion This is the first study to show that prenatal BPA exposure dysregulated the expression of ASD-related genes and functions, including cortical neuritogenesis and development and social behaviors, in a sex-dependent manner. Our findings suggest that, besides the hippocampus, BPA could also exert its adverse effects through sex-specific molecular mechanisms in the offspring’s prefrontal cortex, which in turn would lead to sex differences in ASD-related neuropathology and clinical manifestations, which deserves further investigation.

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Bisphenol A release from short-term degraded resin-based dental materials

Cited by 12 publications

References 41 publications

Fabrication of 3D Printed Hollow Microneedles by Digital Light Processing for the Buccal Delivery of Actives

Fabrication of 3D Printed Hollow Microneedles by Digital Light Processing for the Buccal Delivery of Actives

Sustainability in dentistry part II: Sustainability and the use of chemicals in dentistry

Sex-specific impacts of prenatal bisphenol A exposure on genes associated with cortical development, social behaviors, and autism in the offspring’s prefrontal cortex

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