Bisphenol A release from orthodontic adhesives measured in vitro and in vivo with gas chromatography

Moreira, Marília Rodrigues; Matos, Leonardo Gontijo; Souza, Israel Donizéti de; Brigante, Tamires Amabile Valim; Queiroz, Maria Eugênia Costa; Romano, Fábio Lourenço; Filho, Paulo Nelson; Matsumoto, Mírian Aiko Nakane

doi:10.1016/j.ajodo.2016.07.019

Cited by 43 publications

(59 citation statements)

References 36 publications

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“…has been questioned and the levels have not been confirmed by later studies. Other authors have evaluated the release of BPA in saliva after placement of Bis‐GMA‐based dental materials used as restoratives and in orthodontic treatment, bonding lingual retainers , or brackets . The salivary BPA levels reported in these studies are considerably lower than the levels reported in the present study.…”

Section: Discussioncontrasting

confidence: 67%

“…In the last two decades, the amounts of BPA present in saliva and urine after placement of dental polymer‐based materials have been examined in several studies . However, there are wide differences in the materials tested regarding composition, brands, and application modes.…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that Bis‐DMA‐based materials, such as Delton LC fissure sealant (Ash/Dentsply, York, PA, USA), may release BPA as a result of hydrolysis at the ester bond , whereas Bis‐GMA‐based materials, which typically comprise restorative materials, do not undergo this form of biodegradation because its ether bond is resistant to hydrolysis . Several in‐vitro and some in‐vivo studies have focused on BPA leakage from dental polymer‐based filling materials and have attempted to quantify the amounts detected in different solutions or biological media . However, the amounts reported vary, probably because of differences in the materials examined and the methodological approaches .…”

mentioning

confidence: 99%

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Bisphenol A in human saliva and urine before and after treatment with dental polymer‐based restorative materials

Berge

Lygre

Lie

et al. 2019

European J Oral Sciences

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The aim of this study was to quantify bisphenol A (BPA) concentrations in saliva and urine before and after treatment with dental polymer‐based restorative materials to assess if placement of this material is associated with increased BPA levels in saliva and urine. Twenty individuals in need of at least one dental restoration with polymer‐based restorative material were included in this study. The participants were instructed to abstain from eating, drinking, and brushing their teeth for at least 10 h prior to sampling. Saliva and urine were collected before and 10 min (saliva only), 1 h, 24 h, and 1 wk after treatment. Samples were stored at −80°C before analyses. BPA in saliva and urine was determined with liquid chromatography/mass spectrometry. Linear mixed effects regression models were used for statistical analyses. There was a statistically significant increase of salivary BPA concentration directly after placement of the dental polymer‐based restorations. Following placement, the concentration of BPA decreased exponentially with time. One week after treatment the BPA level in saliva was only marginally higher than before treatment. In urine, no statistically significant change of the BPA concentration was detected after treatment.

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Section: Discussioncontrasting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Bisphenol A in human saliva and urine before and after treatment with dental polymer‐based restorative materials

Berge

Lygre

Lie

et al. 2019

European J Oral Sciences

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“…Unfavorable environmental conditions intensify degradation of materials used in dentistry, including orthodontics [49]. Many research teams focus their activities not only on assessing the usability of dental adhesive materials, but also on validating the stability of their chemical structure [30,36] in the context of potential biological effects [39] on the patient's body. It has been shown that potentially harmful substances may be released into the patient's body as a result of insufficient polymerization of dental adhesive systems [47], or following degradation and aging of materials [27].…”

Section: Chemical Stability Of Orthodontic Adhesive Systems In the Ormentioning

confidence: 99%

Orthodontic adhesive systems –over half a century of research and experience

Kuśmierczyk¹,

Małkiewicz²

2019

jos

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A B S T R AC TNowadays, during orthodontic treatment, brackets of fixed appliances are attached directly to tooth enamel. Research on development and improvement of orthodontic adhesives has been going on for over 50 years and is progressing in many directions. As a result, new solutions are introduced into clinical practice to improve functionality of adhesive systems being applied. Demands set for an adhesive system dedicated to orthodontic use, are primarily: ability to transfer orthodontic forces onto teeth in three spatial dimensions, resistance to masticatory forces, resistance to oral environment, ability to accurately position brackets and maintain them throughout treatment, possibility of detaching brackets without causing damage to tooth enamel and biocompatibility. Products available on the market do not constitute a homogeneous group in terms of both chemical structure and functional features. This paper presents the history of development of orthodontic adhesive systems and their features in relation to clinical use. Attention was also paid to directions of evolution of the aforementioned group of materials aimed at improving their performance in certain aspects of medical practice. Despite the ongoing research and development work, no orthodontic adhesive system that meets all the requirements set for "ideal material" has been developed to date. Orthodontic adhesives introduced into the market require assessment of their actual clinical usability and safety in treatment of patients.

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“…The risk for SIRR is increased for 3 reasons: (1) female patients with enlarged dental follicles and anomalous lateral incisors are more affected; (2) lateral incisors are affected more than central incisors, and the chance of bilateral occurrence is high; and (3) SIRR is found in both palatally and buccally impacted maxillary canines but may be associated with more severely displaced canines, situated in the middle third of the adjacent incisor roots. 1 The diagnostic problems and treatment risks associated with the alignment of impacted canines demand early detection of tooth eruption disturbances. They are of special importance for treatment planning in patients with impacted canines and root resorptions on adjacent teeth.…”

mentioning

confidence: 99%