Bisphenol A interferes with thyroid specific gene expression

Gentilcore, Daniela; Porreca, Immacolata; Rizzo, Francesca; Ganbaatar, Erdentuya; Carchia, Emanuele; Mallardo, Massimo; Felice, Mario De; Ambrosino, Concetta

doi:10.1016/j.tox.2012.12.001

Cited by 109 publications

(71 citation statements)

References 86 publications

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“…This correlation was higher in pregnant mothers exposed to BPA (p < 0.01) [104]. The mechanism of action of BPA in the cells responsible for the synthesis of thyroid hormones, however, has not been completely explained yet [114].…”

Section: Male Genital Abnormalitiesmentioning

confidence: 88%

Bisphenol A – Application, sources of exposure and potential risks in infants, children and pregnant women

Mikołajewska¹,

Stragierowicz²,

Gromadzińska³

2015

Int J Occup Med Environ Health

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Bisphenol A (BPA) is used in the chemical industry as a monomer in the production of plastics. It belongs to a group of compounds that disturb some of the functions of human body, the endocrine system in particular. Extensive use of BPA in manufacturing products that come in contact with food increases the risk of exposure to this compound, mainly through the digestive tract. Literature data indicate that exposure to bisphenol A even at low doses may result in adverse health effects. The greatest exposure to BPA is estimated among infants, children and pregnant women. The aim of this review is to show potential sources of exposure to bisphenol A and the adverse health effects caused by exposure to this compound in the group of particular risk.

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Section: Male Genital Abnormalitiesmentioning

confidence: 88%

Bisphenol A – Application, sources of exposure and potential risks in infants, children and pregnant women

Mikołajewska¹,

Stragierowicz²,

Gromadzińska³

2015

Int J Occup Med Environ Health

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“…BPA affects the expression of thyroid specifi c genes that have been implicated in thyroid development, as well as control of gene expression in rat thyroid cells and zebra fi sh embryos in vitro (Gentilcore et al 2013 ). BPA antagonizes triiodothyronine (T3) action at the transcriptional level in human TSA201 cells, through displacement of T3 from the hormone receptor (TSH) and recruitment of a transcriptional repressor (a T3-negatively regulated TSHalpha promoter), resulting in gene suppression (Moriyama et al 2002 ).…”

Section: Effects Of In Utero Exposure To Bisphenol a On Male Reproducmentioning

confidence: 99%

Adverse Effects of Bisphenol A on Male Reproductive Function

Manfo

Jubendradass

Nantia

et al. 2013

Reviews of Environmental Contamination and Toxicology

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BPA is a ubiquitous environmental contaminant, resulting mainly from manufacturing,use or disposal of plastics of which it is a component, and the degradation of industrial plastic-related wastes. Growing evidence from research on laboratory animals, wildlife, and humans supports the view that BPA produces an endocrine disrupting effect and adversely affects male reproductive function. To better understand the adverse effects caused by exposure to BPA, we performed an up-to-date literature review on the topic, with particular emphasis on in utero exposure, and associated effects on spermatogenesis, steroidogenesis, and accessory organs.BPA studies on experimental animals show that effects are generally more detrimental during in utero exposure, a critical developmental stage for the embryo. BPA has been found to produce several defects in the embryo, such as feminization of male fetuses, atrophy of the testes and epididymides, increased prostate size, shortening of AGD, disruption of BTB, and alteration of adult sperm parameters (e.g.,sperm count, motility, and density). BPA also affects embryo thyroid development.During the postnatal and pubertal periods and adulthood, BPA affects the hypothalamic-pituitary-testicular axis by modulating hormone (e.g., LH and FSH,androgen and estrogen) synthesis, expression and function of respective receptors(ER, AR). These effects alter sperm parameters. BPA also induces oxidative stress in the testis and epididymis, by inhibiting antioxidant enzymes and stimulating lipid peroxidation. This suggests that employing antioxidants may be a promising strategy to relieve BPA-induced disturbances.Epidemiological studies have also provided data indicating that BPA alters male reproductive function in humans. These investigations revealed that men occupationally exposed to BPA had high blood/urinary BPA levels, and abnormal semen parameters. BPA-exposed men also showed reduced libido and erectile ejaculatory difficulties; moreover, the overall BPA effects on male reproduction appear to be more harmful if exposure occurs in utero. The regulation of BPA and BPA-related products should be reinforced, particularly where exposure during the fetal period can occur. The current TDI for BPA is proposed as 25 and 50 1-1g/kg bwt/day (European Food Safety Authority and Health Canada, respectively). Based on the evidence available, we believe that a TDI value of 5 1-1g/kg bwt/day is more appropriate (the endpoint is modulation of rat testicular function). Certain BPA derivatives are being considered as alternatives to BPA. However, certain of these related products display adverse effects that are similar to those of BPA. These effects should be carefully considered before using them as final alternatives to BPA in plastic production.

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“…FRTL-5 is a rat thyroid follicular cell line that is typically used to determine changes in iodide uptake (Arturi et al, 2002;LecatGuillet and Ambroise, 2008;Weiss et al, 1984). Recently, gene expression analysis has been applied to these cell lines to understand the toxicity of environmental chemicals (Gentilcore et al, 2013;Guo and Zhou, 2013). In addition to these cell lines, zebrafish embryos/larvae were also used in the present study in order to determine the in vivo response to TPP exposure during this sensitive stage of life.…”

Section: Introductionmentioning

confidence: 99%