Bisphenol-A induced oxidative stress, inflammatory gene expression, and metabolic and histopathological changes in male Wistar albino rats: protective role of boron

Acaröz, Ulaş; İnce, Sinan; Arslan‐Acaröz, Damla; Gürler, Zeki; Demirel, Hasan Hüseyin; Küçükkurt, İ̇smail; Eryavuz, Abdullah; Kara, Recep; Varol, Nuray; Zhu, Kui

doi:10.1039/c8tx00312b

Cited by 71 publications

(37 citation statements)

References 42 publications

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“…In this animal model, BPA seems to increase liver cell malondialdehyde (MDA) levels, a lipid peroxidation marker, and contemporarily reduce glutathione (GSH), the main antioxidant defense of the hepatocytes [39]. Moreover, in the same animal model, a 30-day BPA administration at a dosage of 25 mg/kg, decreased also CAT and superoxide dismutase (SOD) activity levels [40]. Interestingly, the authors also evaluated liver levels of miRNAs (MiR) regulating the production of several inteleukins: pro-inflammatory (TNF-α, IL-1, IL-6) and anti-inflammatory ones (IL-10) demonstrating an increase of the first group and a decrease of the second.…”

Section: Edcs and Metabolic Diseasesmentioning

confidence: 99%

“…Interestingly, the authors also evaluated liver levels of miRNAs (MiR) regulating the production of several inteleukins: pro-inflammatory (TNF-α, IL-1, IL-6) and anti-inflammatory ones (IL-10) demonstrating an increase of the first group and a decrease of the second. This finding highlighted, one more time, the direct link between oxidative stress induction and the generation of an inflammatory microenvironment that represents the pathogenetic key to explain the worsening of NAFLD in this setting [40].…”

Section: Edcs and Metabolic Diseasesmentioning

confidence: 99%

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Chemical Effect of Bisphenol A on Non-Alcoholic Fatty Liver Disease

Dallio

Diano

Masarone

et al. 2019

IJERPH

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Non-alcoholic fatty liver disease (NAFLD) is considered a predominant chronic liver disease worldwide and a component of metabolic syndrome. Due to its relationship with multiple organs, it is extremely complex to precisely define its pathogenesis as well as to set appropriate therapeutic and preventive strategies. Endocrine disruptors (EDCs) in general, and bisphenol A (BPA) in particular, are a heterogeneous group of substances, largely distributed in daily use items, able to interfere with the normal signaling of several hormones that seem to be related to type 2 diabetes mellitus (T2DM), obesity, and other metabolic disorders. It is reasonable to hypothesize a BPA involvement in the pathogenesis and evolution of NAFLD. However, its mechanisms of action as well as its burden in the vicious circle that connects obesity, T2DM, metabolic syndrome, and NAFLD still remain to be completely defined. In this review we analyzed the scientific evidence on this promising research area, in order to provide an overview of the harmful effects linked to the exposure to EDCs as well as to frame the role that BPA would have in all phases of NAFLD evolution.

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Section: Edcs and Metabolic Diseasesmentioning

confidence: 99%

Section: Edcs and Metabolic Diseasesmentioning

confidence: 99%

Chemical Effect of Bisphenol A on Non-Alcoholic Fatty Liver Disease

Dallio

Diano

Masarone

et al. 2019

IJERPH

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“…Even a low dose of chronic exposure to bisphenols suppresses the luteinizing hormone, follicle-stimulating hormones, and prolactin, exhibiting estrogenic and antiandrogenic effects and affecting spermatogenesis [12,47,48]. Common reproductive abnormalities include premature puberty, ovarian dysfunction, implantation failure, 2. Bisphenol B (BPB) C 16 liver dysfunction, cardiovascular diseases, reproductive, and developmental abnormalities [38][39][40][41]. Bisphenols are metabolic disruptors, and even early-life exposure at low concentrations can result in impaired metabolic functions and toxicity to several organs or systems.…”

Section: Endocrine Disruption and Reproductive Abnormalitiesmentioning

confidence: 99%

Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability

Kim

Kumar

et al. 2019

IJERPH

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Bisphenols are widely used in the synthesis of polycarbonate plastics, epoxy resins, and thermal paper, which are used in manufacturing items of daily use. Packaged foods and drinks are the main sources of exposure to bisphenols. These chemicals affect humans and animals by disrupting the estrogen, androgen, progesterone, thyroid, and aryl hydrocarbon receptor functions. Bisphenols exert numerous harmful effects because of their interaction with receptors, reactive oxygen species (ROS) formation, lipid peroxidation, mitochondrial dysfunction, and cell signal alterations. Both cohort and case-control studies have determined an association between bisphenol exposure and increased risk of cardiovascular diseases, neurological disorders, reproductive abnormalities, obesity, and diabetes. Prenatal exposure to bisphenols results in developmental disorders in animals. These chemicals also affect the immune cells and play a significant role in initiating the inflammatory response. Exposure to bisphenols exhibit age, gender, and dose-dependent effects. Even at low concentrations, bisphenols exert toxicity, and hence deserve a critical assessment of their uses. Since bisphenols have a global influence on human health, the need to discover the underlying pathways involved in all disease conditions is essential. Furthermore, it is important to promote the use of alternatives for bisphenols, thereby restricting their uses.

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“…This mineral, which has serious reserves in our country, has widespread uses (glass, ceramics, cleaning, whitening, cosmetics, metallurgy, nuclear, computer, aircraft industry, energy industry, agriculture and health) (Helvacı, 2003). Borax mineral is effective on hormone and lipid metabolism as well as free radicals of many enzymes (Comba, Oto, Mis, Özdemir, & Comba 2016;Acaroz et al, 2019). One of the most common boron minerals, colemanite (COL), is a monoclinic crystalline calcium borate mineral with chemical formula 2CaO • 3B2O3 • 5H2O (Kızılca & Copur, 2015).…”

Section: Introductionmentioning

confidence: 99%

Oxidative and DNA Damage Potential of Colemanite on Zebrafish: Brain, Liver and Blood

Alak¹,

Parlak²,

Uçar³

et al. 2020

Turkish Journal of Fisheries and Aquatic Sciences

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Recently, boron has been used in animal feeding due to its significant biological roles. In this study, the action mechanism of colemanite (COL), a commercially important borate mineral, was aimed to investigate via evaluating parameters related to oxidative alterations on the brain, liver and blood tissues of zebrafish. For this purpose, zebrafish were exposed to different doses of COL (5, 10 and 20 mg/L) in a static test apparatus for 96 hours. Multiple biochemical analysis including determination of DNA damage (8-OHdG), apoptosis (Caspase-3), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), myeloperoxidase (MPO), paraoxonase (PON), arylesterase (AR) and lipid peroxidation (MDA) levels were performed in brain and liver tissues for assessing oxidative responses. In addition to micronucleus (MN) assay was performed in obtained blood tissues. The results indicated that low doses of COL supported antioxidant system and did not lead to oxidative stress in zebrafish brain and liver. Again, our results showed colemanite did not cause DNA damage or apoptosis at all tested concentrations. Besides the statistically insignificant changes (P>0.05) of MN rates of erythrocytes between the control and experimental groups revealed the non-genotoxic feature of COL on zebrafish. In conclusion, boron compounds especially COL can be used safely and provide positive impacts on aquatic environments.

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Bisphenol-A induced oxidative stress, inflammatory gene expression, and metabolic and histopathological changes in male Wistar albino rats: protective role of boron

Abstract: Boron reversed Bisphenol-A induced alterations.

Cited by 71 publications

References 42 publications

Chemical Effect of Bisphenol A on Non-Alcoholic Fatty Liver Disease

Chemical Effect of Bisphenol A on Non-Alcoholic Fatty Liver Disease

Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability

Oxidative and DNA Damage Potential of Colemanite on Zebrafish: Brain, Liver and Blood

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