Bisphenol-A in breast adipose tissue of breast cancer cases and controls

Reeves, Katherine W.; Schneider, Sallie S.; Xue, Jingchuan; Mason, Holly; Johnson, Melissa; Makari-Judson, Grace; Santana, Mary Díaz

doi:10.1016/j.envres.2018.08.033

Cited by 21 publications

(16 citation statements)

References 23 publications

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“…In breast cancer patients, there was a 3‐ to 4‐fold increase in this value (mean urinary level was 5.76 ± 6.00 ng/ml in cases). This was higher than previously reported values in cases with breast cancer (after adjusting for creatinine clearance), approximating nearly 0.71 ± 0.31 ng/g in breast adipocytes (Reeves et al, 2018). The level was higher in the blood samples of cancer patients in another case–control study (mean blood BPA was 13.87 ng/L (Yang et al, 2009), and in the general population (noncancer volunteers) in urine (0.37 ng/g creatinine in rural areas vs. 0.46 ng/g in urban areas) owing to chronic low‐dose environmental exposures (Battal et al, 2014).…”

Section: Resultscontrasting

confidence: 67%

Exposure of bisphenol A in breast cancer patients—quantitatively assessed by sensitivity‐enhanced high‐performance liquid chromatography coupled with fluorescence detection: A case–control study

Muthusamy

Palanisamy

Ramalingam

2021

Biomedical Chromatography

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A simple, reproducible and sensitive liquid chromatography (HPLC) method has been developed and validated for estimation of bisphenol A (BPA) in human urine. A simple liquid–liquid extraction technique was used in BPA sample preparation. The analyte was chromatographed on a Shimadzu Prominence HPLC system using isocratic mobile phase conditions at a flow rate of 0.500 ml/min and a Hypersil Gold C18 column maintained at 40°C. Quantification was performed on a fluorescence detector set at excitation 275 nm, emission 313 nm and bisphenol B was used as internal standard. The total run time was 8 min. The method was found to have acceptable sensitivity, selectivity, accuracy (98.82–103.64%), precision (1.17–5.36) and stability in the validation experiment carried out as per the USFDA guidelines. The method sensitivity was as low as 0.50 ng/ml. The applicability of the validated analytical method was established in human patient urine samples. The mean human urine BPA concentrations were 1.18 ± 2.11 ng/ml in the control group and 5.76 ± 6.00 ng/ml in the patient group (P < 0.001). Therefore, this method could be considered as an alternative for routine bio‐monitoring of BPA which is less expensive and feasible in resource‐poor settings.

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Section: Resultscontrasting

confidence: 67%

Exposure of bisphenol A in breast cancer patients—quantitatively assessed by sensitivity‐enhanced high‐performance liquid chromatography coupled with fluorescence detection: A case–control study

Muthusamy

Palanisamy

Ramalingam

2021

Biomedical Chromatography

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“…Given their lipophilic property, bisphenols may accumulate in adipose tissue and exert long-term effects (4,77). On the other hand, in breast adipose tissue samples provided by 36 breast cancer mastectomy patients and 14 reduction mammoplasty patients BPA concentrations are similar (0.39 vs. 0.41 ng/g, p = 0.74) (79).…”

Section: Human Environmental Exposuresmentioning

confidence: 96%

Bisphenols and Risk of Breast Cancer: A Narrative Review of the Impact of Diet and Bioactive Food Components

et al. 2020

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Data from preclinical studies suggest a link between increased risk of breast cancer and exposure to bisphenols at doses below what the United States Food and Drug Administration (FDA) considers as safe for consumption. Bisphenols exert estrogenic effects and are found in canned and plastic wrapped foods, food packaging, and plasticware. Mechanistically, bisphenols bind to the estrogen receptor (ER) and activate the expression of genes associated with cell proliferation and breast cancer. In this paper, we present a narrative literature review addressing bisphenol A and chemical analogs including bisphenol AF, bisphenol F, and bisphenol S selected as prototype xenoestrogens; then, we discuss biological mechanisms of action of these bisphenols in breast cells and potential impact of exposure at different stages of development (i.e., perinatal, peripubertal, and adult). Finally, we summarize studies detailing interactions, both preventative and promoting, of bisphenols with food components on breast cancer risk. We conclude the review with a discussion of current controversies in interpretation of the above research and future areas for investigation, including the impact of bisphenols and food components on breast tumor risk.

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“…However, although BPA has been linked to hormone dependent cancer risk in animals its evidence in human is scare [31][32][33]. However, the number of epidemiological studies addressing this issue is growing [34][35][36][37][38][39]. Tough some of them have showed certain suffers from limitations the samples were collected after breast cancer diagnosis or have the limitation characteristic of retrospective case-control studies.…”

Section: Introductionmentioning

confidence: 99%

Bisphenol-A exposure and risk of breast and prostate cancer in the Spanish European Prospective Investigation into Cancer and Nutrition study

et al. 2021

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Background Bisphenol A (BPA) is an endocrine disruptor that it is present in numerous products of daily use. The aim of this study was to assess the potential association of serum BPA concentrations and the risk of incident breast and prostate cancer in a sub-cohort of the Spanish European Prospective Investigation into Cancer and Nutrition (EPIC). Methods We designed a case-cohort study within the EPIC-Spain cohort. Study population consisted on 4812 participants from 4 EPIC-Spain centers (547 breast cancer cases, 575 prostate cancer cases and 3690 sub-cohort participants). BPA exposure was assessed by means of chemical analyses of serum samples collected at recruitment. Borgan II weighted Cox regression was used to estimate hazard ratios. Results Median follow-up time in our study was 16.9 years. BPA geometric mean serum values of cases and sub-cohort were 1.12 ng/ml vs 1.10 ng/ml respectively for breast cancer and 1.33 ng/ml vs 1.29 ng/ml respectively for prostate cancer. When categorizing BPA into tertiles, a 40% increase in risk of prostate cancer for tertile 1 (p = 0.022), 37% increase for tertile 2 (p = 0.034) and 31% increase for tertile 3 (p = 0.072) was observed with respect to values bellow the limit of detection. No significant association was observed between BPA levels and breast cancer risk. Conclusions We found a similar percentage of detection of BPA among cases and sub-cohort from our population, and no association with breast cancer risk was observed. However, we found a higher risk of prostate cancer for the increase in serum BPA levels. Further investigation is needed to understand the influence of BPA in prostate cancer risk.

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Bisphenol-A in breast adipose tissue of breast cancer cases and controls

Cited by 21 publications

References 23 publications

Exposure of bisphenol A in breast cancer patients—quantitatively assessed by sensitivity‐enhanced high‐performance liquid chromatography coupled with fluorescence detection: A case–control study

Exposure of bisphenol A in breast cancer patients—quantitatively assessed by sensitivity‐enhanced high‐performance liquid chromatography coupled with fluorescence detection: A case–control study

Bisphenols and Risk of Breast Cancer: A Narrative Review of the Impact of Diet and Bioactive Food Components

Bisphenol-A exposure and risk of breast and prostate cancer in the Spanish European Prospective Investigation into Cancer and Nutrition study

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