Bisphenol A glucuronidation in patients with Parkinson’s disease

Landolfi, Annamaria; Troisi, Jacopo; Savanelli, Maria Cristina; Barone, Paolo; Amboni, Marianna

doi:10.1016/j.neuro.2017.09.008

Cited by 26 publications

(25 citation statements)

References 44 publications

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“…Although it is known that neuronal tissue is sensitive to BPA and changes caused by this substance have been observed in various parts in both the central and peripheral nervous systems [ 25 , 26 ], these changes consist of disturbances in the development of dendrites and axons, changes in synaptogenesis, abnormalities in intraneuronal calcium ion transport, changes in neurochemical characterization of neuronal cells and nerve fibers, and disturbances in higher neuronal functions, including memory and learning [ 27 ]. Moreover, some investigations connect a high degree of exposure to BPA with neurodegenerative disorders, such as Alzheimer’s or Parkinson’s diseases [ 28 , 29 ]. Although it is known that even low doses of BPA may result in changes in the expression of neuronal active substances within the nerve fibers located in the uterine wall [ 10 ], it should be underlined that knowledge concerning this issue is extremely fragmentary.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Bisphenol a on the Nitrergic Nervous Structures in the Domestic Porcine Uterus

Rytel

Gonkowski

2020

IJMS

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Bisphenol A (BPA) is one of the most common environmental pollutants among endocrine disruptors. Due to its similarity to estrogen, BPA may affect estrogen receptors and show adverse effects on many internal organs. The reproductive system is particularly vulnerable to the impact of BPA, but knowledge about BPA-induced changes in the innervation of the uterus is relatively scarce. Therefore, this study aimed to investigate the influence of various doses of BPA on nitrergic nerves supplying the uterus with the double immunofluorescence method. It has been shown that even low doses of BPA caused an increase in the number of nitrergic nerves in the uterine wall and changed their neurochemical characterization. During the present study, changes in the number of nitrergic nerves simultaneously immunoreactive to substance P, vasoactive intestinal polypeptide, pituitary adenylate cyclase-activating peptide, and/or cocaine- and amphetamine-regulated transcript were found under the influence of BPA. The obtained results strongly suggest that nitrergic nerves in the uterine wall participate in adaptive and/or protective processes aimed at homeostasis maintenance in the uterine activity under the impact of BPA.

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Section: Introductionmentioning

confidence: 99%

The Influence of Bisphenol a on the Nitrergic Nervous Structures in the Domestic Porcine Uterus

Rytel

Gonkowski

2020

IJMS

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“…Moreover, even short exposure to BPA may result in disorders in higher neural activity, including learning, cognition, and memorizing, which may occur a long time after intoxication . Moreover, previous studies have suggested that there is a relationship between exposure to BPA and the risk of neurodegenerative diseases, such as Alzheimer's or Parkinson's diseases . In turn, in the reproductive system, exposure to BPA may result in the changes within the uterus, including the inhibition of uterine epidermal apoptosis and an increase in the thickness of the uterine mucosal layer .…”

Section: Introductionmentioning

confidence: 99%

“…6,10 Moreover, previous studies have suggested that there is a relationship between exposure to BPA and the risk of neurodegenerative diseases, such as Alzheimer's or Parkinson's diseases. 11,12 In turn, in the reproductive system, exposure to BPA may result in the changes within the uterus, including the inhibition of uterine epidermal apoptosis and an increase in the thickness of the uterine mucosal layer. 13 Moreover, it is known that exposure to BPA results in disturbances in estrogen metabolism, disorders in the estrus cycle, pregnancy, and embryo implantation.…”

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confidence: 99%

Neurochemical characterization of the enteric neurons within the porcine jejunum in physiological conditions and under the influence of bisphenol A (BPA)

Szymańska

Gonkowski

2019

Neurogastroenterology Motil

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Background Bisphenol A (BPA) is commonly used in the production of plastics and has multidirectional, negative effects on the living organisms. It may also affect the enteric nervous system (ENS) located in the wall of the gastrointestinal tract. Enteric neurons express many active substances, which regulate majority of intestinal activities not only in physiological conditions but also under the impact of pathological factors. Methods The influence of various doses of BPA on the ENS of jejunum has been investigated using the double immunofluorescence technique. The commercial antibodies against substance P (SP), vasoactive intestinal polypeptide (VIP), galanin (GAL), vesicular acetylcholine transporter (VAChT), and cocaine‐ and amphetamine‐regulated transcript peptide (CART) were used. Key Results Both doses of BPA studied changed the number of the enteric neurons immunoreactive to SP, VIP, GAL, VAChT, and CART, and the intensity of fluctuations depended on the BPA dose and on the type of the enteric plexus. Bisphenol A causes the increase in the number of neurons immunoreactive to the majority of substances studied. The only exception was VAChT‐positive neurons, the number of which was lower under the impact of BPA in the comparison with physiological conditions. Conclusions & Inferences Even low doses of BPA cause the changes in neurochemical characterization of the enteric neurons in the jejunum. These changes may be the first sign of subclinical BPA intoxication. The mechanisms of observed changes are probably connected with neurotoxic and/or pro‐inflammatory activity of BPA, but their exact mechanisms are not fully explained.

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“…The changes mentioned above lead to disturbances in higher neuronal functions, such as behavior, memory, and/or learning (Johnson et al 2016 ). Some neuronal symptoms may appear only after many months of exposure to BPA (Hutter et al 2016 ), and in the light of the previous studies, the participation of BPA in the pathogenesis of neurodegenerative diseases, including Alzheimer’s or Parkinson’s diseases, cannot be excluded (Landolfi et al 2017 ; Wang et al 2017 ).…”

Section: Introductionmentioning

confidence: 99%

The Neurochemical Characterization of Parasympathetic Nerve Fibers in the Porcine Uterine Wall Under Physiological Conditions and After Exposure to Bisphenol A (BPA)

et al. 2019

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Bisphenol A, a substance commonly used in plastic manufacturing, is relatively well known as an endocrine disruptor, which may bind to estrogen receptors and has multidirectional negative effects on both human and animal organisms. Previous studies have reported that BPA may act on the reproductive organs, but knowledge concerning BPA-induced changes within the nerves located in the uterine wall is extremely scant. The aim of this study was to investigate the impact of various doses of BPA on the parasympathetic nerves located in the corpus and horns of the uterus using a single and double immunofluorescence method. The obtained results have shown that BPA may change not only the expression of vesicular acetylcholine transporter (VAChT—a marker of parasympathetic nervous structures) in the uterine intramural nerve fibers, but also the degree of colocalization of this substance with other neuronal factors, including substance P (SP), vasoactive intestinal polypeptide (VIP), galanin (GAL), and calcitonin gene–related peptide (CGRP). Moreover, BPA caused changes in the density of the overall populations of fibers immunoreactive to the particular neuropeptides mentioned above. The characteristics of the changes clearly depended on the part of the uterus, the neuronal factors studied, and the dosage of BPA. The mechanisms of the observed fluctuations are probably connected with the neurotoxic and/or pro-inflammatory activity of BPA. Moreover, the results have shown that even low doses of BPA are not neutral to living organisms. Changes in the neurochemical characterization of nerves supplying the uterine wall may be the first subclinical sign of intoxication with this substance.

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Bisphenol A glucuronidation in patients with Parkinson’s disease

Cited by 26 publications

References 44 publications

The Influence of Bisphenol a on the Nitrergic Nervous Structures in the Domestic Porcine Uterus

The Influence of Bisphenol a on the Nitrergic Nervous Structures in the Domestic Porcine Uterus

Neurochemical characterization of the enteric neurons within the porcine jejunum in physiological conditions and under the influence of bisphenol A (BPA)

The Neurochemical Characterization of Parasympathetic Nerve Fibers in the Porcine Uterine Wall Under Physiological Conditions and After Exposure to Bisphenol A (BPA)

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