Bisphenol A exposure and type 2 diabetes mellitus risk: a meta-analysis

Hwang, Semi; Lim, Jae Yol; Choi, Youn Jeong; Jee, Sun Ha

doi:10.1186/s12902-018-0310-y

Cited by 101 publications

(47 citation statements)

References 43 publications

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“…In a Chinese population case-control study of 251 cases of diabetes mellitus type 2 (DM2) and 251 controls, urinary concentrations of bisphenols (BPAF and BPS) were found to be positively correlated with DM2 [78]. A meta-analysis study determined that BPA toxicity is related to an increased risk of DM2; they reported that both urine and serum BPA levels are positively associated with the risk of DM2 [80]. In a cross-sectional study on the middle-aged and elderly Chinese population, a positive association was found between generalized obesity, abdominal obesity, and insulin resistance [82].…”

Section: Obesity and Diabetesmentioning

confidence: 99%

“…Children are more prone to bisphenol exposure, and even low concentrations (≤100 µM) are toxic to brain development in both prenatal and childhood stage [89,[121][122][123][124][125]. Exposure to BPA in the first trimester of pregnancy is associated with sleep-related problems in preschool children [80]. In a longitudinal birth cohort study in California, Harley et al observed that prenatal and early childhood BPA exposure of children results in behavioral problems, including anxiety, depression, and hyperactivity [123].…”

Section: Neurotoxicitymentioning

confidence: 99%

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Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability

Kim

Kumar

et al. 2019

IJERPH

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Bisphenols are widely used in the synthesis of polycarbonate plastics, epoxy resins, and thermal paper, which are used in manufacturing items of daily use. Packaged foods and drinks are the main sources of exposure to bisphenols. These chemicals affect humans and animals by disrupting the estrogen, androgen, progesterone, thyroid, and aryl hydrocarbon receptor functions. Bisphenols exert numerous harmful effects because of their interaction with receptors, reactive oxygen species (ROS) formation, lipid peroxidation, mitochondrial dysfunction, and cell signal alterations. Both cohort and case-control studies have determined an association between bisphenol exposure and increased risk of cardiovascular diseases, neurological disorders, reproductive abnormalities, obesity, and diabetes. Prenatal exposure to bisphenols results in developmental disorders in animals. These chemicals also affect the immune cells and play a significant role in initiating the inflammatory response. Exposure to bisphenols exhibit age, gender, and dose-dependent effects. Even at low concentrations, bisphenols exert toxicity, and hence deserve a critical assessment of their uses. Since bisphenols have a global influence on human health, the need to discover the underlying pathways involved in all disease conditions is essential. Furthermore, it is important to promote the use of alternatives for bisphenols, thereby restricting their uses.

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Section: Obesity and Diabetesmentioning

confidence: 99%

Section: Neurotoxicitymentioning

confidence: 99%

Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability

Kim

Kumar

et al. 2019

IJERPH

View full text Add to dashboard Cite

show abstract

“…In a Chinese population case-control study of 251 cases of diabetes mellitus type 2 (DM2) and 251 controls, urinary concentrations of bisphenols (BPAF and BPS) were found to be positively correlated with DM2 [79]. A meta-analysis study determined that BPA toxicity is related to an increased risk of DM2; they reported that both urine and serum BPA levels are positively associated with the risk of DM2 [81]. In a cross-sectional study on the middle-aged and elderly Chinese population, a positive association was found between generalized obesity, abdominal obesity and insulin resistance [83].…”

Section: Obesity and Diabetesmentioning

confidence: 99%

“…Children are more prone to bisphenol exposure, and even low concentrations (≤ 100 µ M) are toxic to brain development in both prenatal and childhood stage [90,[119][120][121][122][123]. Exposure to BPA in the first trimester of pregnancy is associated with sleep-related problems in preschool children [81]. In a longitudinal birth cohort study in California, Harley et al observed that prenatal and early childhood BPA exposure of children results in behavioral problems, including anxiety, depression, and hyperactivity [121].…”

Section: Neurotoxicitymentioning

confidence: 99%

Bisphenols as A Legacy Pollutant, and Their Effects on Organ Vulnerability

Kim¹,

Kumar²,

Kumar³

et al. 2019

Preprint

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Bisphenols are widely used in the synthesis of polycarbonate plastics, epoxy resins and thermal paper, which are used in manufacturing items of daily use. Packaged foods and drinks are the main sources of exposure to bisphenols. These chemicals affect humans and animals by disrupting the estrogen, androgen, progesterone, thyroid, and aryl hydrocarbon receptor functions. Bisphenols exert numerous harmful effects because of their interaction with receptors, ROS formation, lipid peroxidation, mitochondrial dysfunction, and cell signal alterations. Both cohort and case-control studies have determined an association between bisphenol exposure and increased risk of cardiovascular diseases, neurological disorders, reproductive abnormalities, obesity, and diabetes. Prenatal exposure to bisphenol results in developmental disorders in animals. These chemicals also affect the immune cells and play a significant role in initiating the inflammatory response. Exposure to bisphenols exhibit age, gender, and dose-dependent effects. Even at low concentrations, bisphenols exert toxicity, and hence deserve a critical assessment for their uses. Since bisphenols have a global influence on human health, the need to discover the underlying pathways involved in all disease conditions is essential. Furthermore, it is important to promote the use of alternatives for bisphenols, thereby restricting their uses.

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“…7,8 Furthermore, epidemiological evidence suggest harmful effects such as infertility, lower male sexual function, reduced sperm quality, changes in endogenous sex hormone concentrations, immunotoxicity, obesity, cardiovascular disease, type-2 diabetes, and neurobehavioral problems. [9][10][11] These effects have been identified at human BPA concentrations that lie below safety thresholds of government agencies. These findings, thus, call into question the frequent use of BPA-containing products and bring about concerns of adverse effects from low-dose chronic exposure.…”

Section: Introductionmentioning

confidence: 99%

Challenges to regulate products containing bisphenol A: Implications for policy

et al. 2019

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Desafíos para regular los productos que contienen bisfenol A: implicaciones para la política. Salud Publica Mex. 2019;61:692-697. https://doi. AbstractBisphenol A (BPA), found in plastics and epoxy resins, is one of the most studied chemicals. BPA is regarded as an endocrine disruptor and has been related to adverse health effects in humans. However, some regulatory agencies around the world have concluded that BPA is safe at current human exposure levels. As the scientific community attempts to settle the debate on BPA's health effects, regulatory agencies have been put into a challenging public health policy situation. The United States has implemented no regulatory actions due to safety concerns, while Europe has used the precautionary principle to guide its regulation in the face of scientific uncertainty. In this paper, we explore the debate surrounding BPA regulation and the possibility for countries to introduce guidelines, using Mexico as an example. Policy change determinants analysis suggest that countries can and should impose regulations on BPA.

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Bisphenol A exposure and type 2 diabetes mellitus risk: a meta-analysis

Cited by 101 publications

References 43 publications

Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability

Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability

Bisphenols as A Legacy Pollutant, and Their Effects on Organ Vulnerability

Challenges to regulate products containing bisphenol A: Implications for policy

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