Bisphenol A Diglycidyl Ether (BADGE) and Progesterone Do Not Induce Ca2+ Signals in Boar Sperm Cells

Rehfeld, Anders; Mendoza, Noelia; Ausejo, Raquel; Skakkebæk, Niels E.

doi:10.3389/fphys.2020.00785

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…Indeed, bisphenols (BPG, BPAF, BPC and BPB) are also able to induce Ca 2+ signals via the CatSper channel and also inhibit progesterone induced Ca 2+ signals in human sperm cells. CatSper is normally activated by progesterone produced by cumular cells ( Rehfeld et al, 2020 ). CatSper is also activated by p,p′-DDE, a metabolite of dichlorodiphenyltrichloroethane (DDT) ( Tavares et al, 2013 ).…”

Section: Main Effect Of Endocrine Disruptors On Male Fertilitymentioning

confidence: 99%

Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes

et al. 2021

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Male fertility has been deteriorating worldwide for considerable time, with the greatest deterioration recorded mainly in the United States, Europe countries, and Australia. That is, especially in countries where an abundance of chemicals called endocrine disruptors has repeatedly been reported, both in the environment and in human matrices. Human exposure to persistent and non-persistent chemicals is ubiquitous and associated with endocrine-disrupting effects. This group of endocrine disrupting chemicals (EDC) can act as agonists or antagonists of hormone receptors and can thus significantly affect a number of physiological processes. It can even negatively affect human reproduction with an impact on the development of gonads and gametogenesis, fertilization, and the subsequent development of embryos. The negative effects of endocrine disruptors on sperm gametogenesis and male fertility in general have been investigated and repeatedly demonstrated in experimental and epidemiological studies. Male reproduction is affected by endocrine disruptors via their effect on testicular development, impact on estrogen and androgen receptors, potential epigenetic effect, production of reactive oxygen species or direct effect on spermatozoa and other cells of testicular tissue. Emerging scientific evidence suggests that the increasing incidence of male infertility is associated with the exposure to persistent and non-persistent endocrine-disrupting chemicals such as bisphenols and perfluoroalkyl chemicals (PFAS). These chemicals may impact men’s fertility through various mechanisms. This study provides an overview of the mechanisms of action common to persistent (PFAS) and nonpersistent (bisphenols) EDC on male fertility.

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Section: Main Effect Of Endocrine Disruptors On Male Fertilitymentioning

confidence: 99%

Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes

et al. 2021

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“…In this study, we have explored the protective effects of CF-C 60 in the non-freezing storage of sperm in a porcine model. This animal model was chosen because pigs are an increasingly prevailing animal model in translational studies based on their resemblance to humans in terms of anatomy, physiology [34], and reproductive maturation and the similarities between porcine and human sperm in terms of reproductive and functional capacity [35][36][37]. We explored the effects of CF-C 60 on sperm quality and its antioxidant, anti-apoptotic, and bactericidal abilities, as well as the underlying mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Carboxyfullerene C60 preserves sperm by enhancing antioxidant capacity and inhibiting apoptosis and harmful bacteria

Li,

Zhang,

Xiao

et al. 2024

Preprint

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Background The current approaches for the preservation of human sperm have several limitations, and there are a lack of effective non-freezing preservation methods. Recently, carboxyfullerene C60 (CF-C60) has gained attention as an important nanocarbon derivative with strong antioxidant and antibacterial activity. This study uses a porcine model to systematically investigate whether CF-C60 can be used for the preservation of sperm. Results The results indicate that CF-C60 supplementation can preserve sperm quality during storage at 17°C. This effect is attributable to improvement in the antioxidant capacity of sperm through a decrease in the ROS level. Additionally, CF-C60 can maintain mitochondrial function, inhibit sperm apoptosis through the ROS/Cytochrome C/Caspase 3 signaling pathway, and mediate suppression of bacterial growth through the effects of ROS. Finally, the results of artificial insemination experiments indicate that insemination with CF-C60-treated sperm can increase the total number of offspring born and reduce the number of deformed piglets. Conclusions Thus, CF-C60 can preserve sperm quality by inhibition of apoptosis and bacterial growth via a reduction in ROS levels and is safe for use as a component of semen diluent for storage. These findings pave the way for the prospective clinical application of carbon nano-materials as antioxidants for non-freezing sperm preservation methods.

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Bisphenol A Diglycidyl Ether (BADGE) and Progesterone Do Not Induce Ca2+ Signals in Boar Sperm Cells

Cited by 2 publications

References 29 publications

Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes

Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes

Carboxyfullerene C60 preserves sperm by enhancing antioxidant capacity and inhibiting apoptosis and harmful bacteria

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