Bisphenol A depresses compound action potential of frog sciatic nerve in vitro involving Ca2+-dependent mechanisms

Pandey, Abhay K.; Deshpande, Shripad B.

doi:10.1016/j.neulet.2012.04.044

Cited by 24 publications

(28 citation statements)

References 27 publications

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“…[11,12] Tamoxifen was seen to block the BPA-induced depression of compound action potential of frog sciatic nerve. [13] Considering these observations, we hypothesized that BPA-induced decrease in force or amplitude of contractions in GI muscles may be mediated through estrogen receptor.…”

Section: Discussionmentioning

confidence: 99%

Effects of chronic ingestion of Bisphenol A on gut contractility in rats

Dixit¹,

Singh²,

Tiwari³

et al. 2017

Natl J Physiol Pharm Pharmacol

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Background: Bisphenol A (BPA) is a plastic toxin widely used in manufacturing of plastic containers. It is known to produce a variety of toxic effects on body functions including reproduction, metabolism, and development. Despite the fact that the gastrointestinal tract is chronically exposed to food containing BPA, its effect on the gut motility is poorly understood. Aims and Objectives: The present study attempted to assess the small and large gut contractility in vitro in male rats fed with BPA-mixed food for 28 days. Materials and Methods: This study was carried out in 8 adult male albino rats of 150-200 g weight. One group (4 rats) was subjected to daily oral administration of BPA (50 µg/kg/day) for 28 days. Another group of 4 rats was Sham-fed and served as control. With the help of organ bath preparations and computerized data acquisition system, in vitro isometric contraction (spontaneous and agonist-induced) was recorded from small gut (distal ileum) and large gut (mid colon) segments. Results: Recordings of spontaneous contractions revealed significantly (P < 0.05) decreased contractile tension in small gut and a decrease in both tension and frequency in large gut of the BPA-fed group of rats. Conclusion: Chronic exposure of BPA depresses spontaneous and agonist-induced contractility of small and large gut of rats.

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Section: Discussionmentioning

confidence: 99%

Effects of chronic ingestion of Bisphenol A on gut contractility in rats

Dixit¹,

Singh²,

Tiwari³

et al. 2017

Natl J Physiol Pharm Pharmacol

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show abstract

“…It is very well documented that BPA and various related compounds bind to hormone receptors and influence multiple endocrine pathways Okada et al, 2008;Swedenborg et al, 2009;Riu et al, 2011;Soriano et al, 2012). Beyond this, recent studies provide evidence that BPA can directly interact with biologically active proteins such as enzymes and ion channels (Hiroi et al, 2006;Asano et al, 2010;Hashimoto et al, 2012;O'Reilly et al, 2012;Pandey and Deshpande, 2012). Protein disulfide isomerase (PDI) has been isolated as a binding protein of BPA in the rat brain.…”

Section: Introductionmentioning

confidence: 99%

Bisphenol A Inhibits Voltage-Activated Ca²⁺ Channels in Vitro: Mechanisms and Structural Requirements

et al. 2012

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“…The level of lysosomal membrane stability (NRR time) was decreased till the critical level; depletion of cholinesterase at tested the neurotoxicity, known for the effect of BPA on different animal models [17]. The absence of the neurotoxic effect of BPA in the presence of Nfd as Ltype Ca 2+ channels antagonist was shown for the frog sciatic nerve [17] demonstrating the dependence of the BPA toxicity on these Ca 2+ channels [17]. However, the evidence of other mecha nisms of neurotoxicity in the coexposure was evident from the depletion of ChE in the mussels in the present study.…”

Section: Resultsmentioning

confidence: 99%

“…The major injury known for BPA is the endocrine disruption [4,17]. The evaluation of the ALP detected this typical effect − the increase of the level of these vitellogenin-like proteins in the gonads of male specimens, despite in the hemolymph their level was not changed by exposure.…”

Section: таблиця 3 біомаркери токсичності у травній залозі (Dg) гемmentioning

confidence: 96%

Multi-marker study of the response of bivalve mollusk Unio tumidus induced by the compounds of typical municipal effluents

Gnatyshyna¹,

Falfushynska²,

Mykhalska³

et al. 2017

Biol. Stud.

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The pharmaceutical and personal care products (PPCPs) became the most typical pollutants of the surface waters. The aim of this study was to evaluate the effects of the combine exposure to the common compounds of the municipal effluents, constituent of plastics bisphenol A (BPA) and popular medicine nifedipine (Nfd), on the model orga nism, a mussel Unio tumidus. Male U. tumidus were exposed for 14 days to the com bination of Nfd (10 μM) and BPA (0.88 nM). The indices of oxidative stress, metabolic, immune and endocrine activity, metal balance, as well as the manifestations of toxicity were detected. The exposure caused the features known for the effect of Nfd: the ac tivation of the oxidative stress response, particularly Cu,Znsuperoxide dismutase (by 6.0 times), glutathione and oxyradical levels, metabolic shift to the anaerobiosis due to the elevated level of lactate in the digestive gland. The manifestation of endocrine dis ruption typical for the BPA effect the increased level of alkalilabile phosphates (vitel logeninlike proteins) in gonads was detected. The caspase3 related apoptotic activity was suppressed; whereas the cathepsin D mediated proteolysis and immune response of phenoloxidase were up-regulated significantly. The signs of geno-, neuro-and cyto toxicity were detected. These results detect that the approximation of the experimental conditions to the environmentally realistic situation could assist the comprehensive fore casting of the effects of utilized PPCPs for the aquatic animals.

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Bisphenol A depresses compound action potential of frog sciatic nerve in vitro involving Ca2+-dependent mechanisms

Cited by 24 publications

References 27 publications

Effects of chronic ingestion of Bisphenol A on gut contractility in rats

Effects of chronic ingestion of Bisphenol A on gut contractility in rats

Bisphenol A Inhibits Voltage-Activated Ca²⁺ Channels in Vitro: Mechanisms and Structural Requirements

Multi-marker study of the response of bivalve mollusk Unio tumidus induced by the compounds of typical municipal effluents

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Bisphenol A depresses compound action potential of frog sciatic nerve in vitro involving Ca2+-dependent mechanisms

Cited by 24 publications

References 27 publications

Effects of chronic ingestion of Bisphenol A on gut contractility in rats

Effects of chronic ingestion of Bisphenol A on gut contractility in rats

Bisphenol A Inhibits Voltage-Activated Ca2+ Channels in Vitro: Mechanisms and Structural Requirements

Multi-marker study of the response of bivalve mollusk Unio tumidus induced by the compounds of typical municipal effluents

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Bisphenol A Inhibits Voltage-Activated Ca²⁺ Channels in Vitro: Mechanisms and Structural Requirements