Bisphenol-A Can Inhibit the Enzymatic Activity of Human Superoxide Dismutase

Prasanth, Ganesh K.; Lakshmanan, M.; Sadasivan, C.

doi:10.1080/10807039.2012.683720

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…As BPA may bind to the SOD sites, thereby inhibiting the enzymatic activity of SOD. Hence, decrease the activities of SOD, thereby leading to increase concentration of SOD [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Alterations of Kiss 1 receptor, GnRH receptor and nuclear receptors of the hypothalamo-pituitary-ovarian axis following low dose bisphenol-A exposure in Wistar rats

et al. 2021

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Bisphenol A is a chemical used primarily as a monomer in the production of polycarbonate plastics and epoxy resins. It is a synthetic chemical compound that is produced in billions of pounds annually, and tagged as an endocrine disruptor. Bisphenol A is a high production synthetic chemical compound that is used in the production of many consumables and equipments of daily consumption and use by man. Growing interest in possible health threats posed by endocrine disrupting chemicals (bisphenol-A inclusive), as these substances are in our environment, food, and many consumer products. Therefore, this study aims to determine bisphenol-A effects on the hypothalamo-pituitary-ovarian axis, and role of melatonin in this regard. Forty-two Wistar rats were bred, grouped into 7, with each group consisting of 6 rats. Experimental groups were administered low and high doses of bisphenol-A and melatonin, starting from day 19, and was continued for 7 weeks orally. They were left to develop into full adults and were sacrificed on day 120±4 days. Blood samples, hypothalamus, pituitary and ovarian tissues were excised for biochemical and tissue antioxidants assays as well as genetic studies. Results show elevated gonadotropin and androgen levels. There was disruption of reactive oxygen species in the ovarian tissues, as well as alterations in the expression of genes that regulate reproduction at the hypothalamus and pituitary levels. Conclusion of early exposure to bisphenol-A is associated with prolonged duration of disruption of reproductive functions in female Wistar rats, which persist long after cessation of the exposure. Melatonin antioxidant effects give some promising outturns against bisphenol-A induced toxicities.

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“…As BPA may bind to the SOD sites, thereby inhibiting the enzymatic activity of SOD. Hence, decrease the activities of SOD, thereby leading to increase concentration of SOD [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Alterations of Kiss 1 receptor, GnRH receptor and nuclear receptors of the hypothalamo-pituitary-ovarian axis following low dose bisphenol-A exposure in Wistar rats

et al. 2021

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“…Proper positioning and orientation of superoxide is required for electron transfer with Cu ion, and is achieved by Arg143. The active site of SOD is completely occupied by BPA via the formation of two hydrogen bonds traversing the substrate-binding cavity [36]. The interruption of the superoxide-copper interaction by BPA binding interferes with catalysis.…”

Section: Sodmentioning

confidence: 99%

“…Further, BPA forms many Van der Waal bonds with functionally important residues, including His48, His63, and Arg143, which prevents proper positioning of the superoxide in the active site. Consequently, BPA directly impairs the free radical-scavenging and enzymatic activities of SOD [36,37]. Ultimately, BPA exposure compromises cellular antioxidant defences by increasing ROS production [24].…”

Section: Sodmentioning

confidence: 99%

Role of Antioxidants in Alleviating Bisphenol A Toxicity

2020

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Bisphenol A (BPA) is an oestrogenic endocrine disruptor widely used in the production of certain plastics, e.g., polycarbonate, hard and clear plastics, and epoxy resins that act as protective coating for food and beverage cans. Human exposure to this chemical is thought to be ubiquitous. BPA alters endocrine function, thereby causing many diseases in human and animals. In the last few decades, studies exploring the mechanism of BPA activity revealed a direct link between BPA-induced oxidative stress and disease pathogenesis. Antioxidants, reducing agents that prevent cellular oxidation reactions, can protect BPA toxicity. Although the important role of antioxidants in minimizing BPA stress has been demonstrated in many studies, a clear consensus on the associated mechanisms is needed, as well as the directives on their efficacy and safety. Herein, considering the distinct biochemical properties of BPA and antioxidants, we provide a framework for understanding how antioxidants alleviate BPA-associated stress. We summarize the current knowledge on the biological function of enzymatic and non-enzymatic antioxidants, and discuss their practical potential as BPA-detoxifying agents.

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Elimination of Estrogenic Activity of Thermal Paper Using Laccase from Trichoderma sp NFCCI-2745

Divya

Prasanth

Sadasivan

2013

Appl Biochem Biotechnol

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In thermal printing, bisphenol A (BPA) functions chemically as a developer and reacts with white or colorless dyes in the presence of heat, converting them to a dark color. BPA can transfer readily to skin in small amounts from these papers. Its damage to environment and organisms has caused an extensive concern. In the present study, thermal paper used at the local automated teller machine counters of India were analyzed for the presence of BPA, and the capability of the paper to produce estrogenicity were assessed using a yeast two-hybrid assay experimental system. The study also focused on eliminating the endocrine-disrupting properties with partially purified laccase from newly isolated ascomycete fungi. The results indicate that these papers can produce estrogen hormone-like effect on experimental systems. It should be noted that on a daily basis, tons of such receipts are being dumped in the environment. Estrogenic properties of thermal paper were effectively removed from the reaction mixture within 3 h of incubation with the partially purified enzyme. We propose the utilization of waste thermal paper as a cheap substrate for laccase production for a safer and cleaner environment.

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Bisphenol-A Can Inhibit the Enzymatic Activity of Human Superoxide Dismutase

Cited by 5 publications

References 35 publications

Alterations of Kiss 1 receptor, GnRH receptor and nuclear receptors of the hypothalamo-pituitary-ovarian axis following low dose bisphenol-A exposure in Wistar rats

Alterations of Kiss 1 receptor, GnRH receptor and nuclear receptors of the hypothalamo-pituitary-ovarian axis following low dose bisphenol-A exposure in Wistar rats

Role of Antioxidants in Alleviating Bisphenol A Toxicity

Elimination of Estrogenic Activity of Thermal Paper Using Laccase from Trichoderma sp NFCCI-2745

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