Bisphenol A (BPA) the mighty and the mutagenic

Jalal, Nasir; Surendranath, Austin Richard; Pathak, Janak L.; Shi, Yu; Chung, Chang Y.

doi:10.1016/j.toxrep.2017.12.013

Cited by 208 publications

(125 citation statements)

References 92 publications

(102 reference statements)

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“…In turn, changes in neurons immunoreactive to various substances suggest multidirectional effects of BPA on the ENS. The fluctuations in the immunoreactivity of the enteric neurons noted in the present study may result from the genotoxic effects of BPA and disturbances in protein synthesis on various levels, as well as disorders in the intraneuronal transport of the active factors studied. The changes are probably connected with pro‐inflammatory neurotoxic and/or relaxant impact of BPA, but it should be noted that the exact mechanisms of the observed fluctuations remain unclear and require further investigation.…”

Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 62%

“…Namely, BPA acts on the mast cells, causing an increase in the production of tumor necrosis factor (TNF)‐α, interleukin (IL)‐6, interferon‐gamma (INF‐γ), IL‐4, histamine, and many other factors, but the kind of immune factors released during exposure to BPA clearly depends on animal species and the toxin dose . Moreover, it is known that BPA affects macrophages, which contributes to the increase in the synthesis of TNF‐α and IL‐6 with a simultaneous decrease in the production of IL‐10 and transforming growth factor (TGF)‐β . BPA‐induced changes have been also observed in the T‐ and B‐lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

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Neurochemical characterization of the enteric neurons within the porcine jejunum in physiological conditions and under the influence of bisphenol A (BPA)

Szymańska

Gonkowski

2019

Neurogastroenterology Motil

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Background Bisphenol A (BPA) is commonly used in the production of plastics and has multidirectional, negative effects on the living organisms. It may also affect the enteric nervous system (ENS) located in the wall of the gastrointestinal tract. Enteric neurons express many active substances, which regulate majority of intestinal activities not only in physiological conditions but also under the impact of pathological factors. Methods The influence of various doses of BPA on the ENS of jejunum has been investigated using the double immunofluorescence technique. The commercial antibodies against substance P (SP), vasoactive intestinal polypeptide (VIP), galanin (GAL), vesicular acetylcholine transporter (VAChT), and cocaine‐ and amphetamine‐regulated transcript peptide (CART) were used. Key Results Both doses of BPA studied changed the number of the enteric neurons immunoreactive to SP, VIP, GAL, VAChT, and CART, and the intensity of fluctuations depended on the BPA dose and on the type of the enteric plexus. Bisphenol A causes the increase in the number of neurons immunoreactive to the majority of substances studied. The only exception was VAChT‐positive neurons, the number of which was lower under the impact of BPA in the comparison with physiological conditions. Conclusions & Inferences Even low doses of BPA cause the changes in neurochemical characterization of the enteric neurons in the jejunum. These changes may be the first sign of subclinical BPA intoxication. The mechanisms of observed changes are probably connected with neurotoxic and/or pro‐inflammatory activity of BPA, but their exact mechanisms are not fully explained.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

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Neurochemical characterization of the enteric neurons within the porcine jejunum in physiological conditions and under the influence of bisphenol A (BPA)

Szymańska

Gonkowski

2019

Neurogastroenterology Motil

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“…Thereby, it must be highlighted that BPA is one of the most widely used synthetic compounds worldwide and can adversely impact human health, especially infants (Jalal et al, 2018). BPA is usually applied in production of specific polycarbonate plastic and epoxy resins coatings for cans.…”

Section: Food-package Interactionmentioning

confidence: 99%

Packaging perspective of milk and dairy products

et al. 2019

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Packaging of dairy products develops continuously along with advances in material technologies, which are in turn a response to demands of consumers. This article aimed to give an overview of currently available dairy packaging systems. Novel dairy packaging systems include new packaging technologies such as the modified atmosphere packaging (MAP) that is widely used nowadays, especially for dairy product like cheese. Application of edible packaging could significantly reduce the costs of cheese packaging by reducing the amount of usually required packaging material. Nanomaterials and active packaging might be useful for extending the shelf life of dairy products by reducing material permeability or negative sensory characteristics of batch processing. Forms of active packaging relevant to dairy foods include oxygen scavenging, carbon dioxide absorbers, moisture and/or flavour/odour taints absorbers; releasing compounds (carbon dioxide, ethanol, antioxidants and/or other preservatives); maintaining temperature control and/or compensating temperature changes and antimicrobial packaging. Antimicrobial packaging is gaining interest from packaging scientists and industry due to its potential for providing quality and their safety benefits. The greatest challenge from the ecological point of view is biodegradable packaging. The main challenges for low waste materials are the durability of the packaging correlated with product shelf life as well as the ecological perspective.

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“…However, BPA was commonly found in human blood with concentrations between 0.1-100 nM [28] and its conjugated form was found in urines samples with average values between 2-650 nM [29]. An interesting study found a statistically higher BPA concentration in urine samples in females than in males and higher BPA in children than in adults [30], but the reasons are not clear yet. A randomized clinical trial showed that consuming canned beverage augmented urinary BPA concentration and increased blood pressure [31,32].…”

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confidence: 99%

The Mechanism of Bisphenol A Atherogenicity Involves Apolipoprotein A-I Downregulation through NF-κB Activation

Trusca¹,

Dumitrescu²,

Fenyo³

et al. 2019

IJMS

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Apolipoprotein A-I (apoA-I) is the major protein component of high-density lipoproteins (HDL), mediating many of its atheroprotective properties. Increasing data reveal the pro-atherogenic effects of bisphenol A (BPA), one of the most prevalent environmental chemicals. In this study, we investigated the mechanisms by which BPA exerts pro-atherogenic effects. For this, LDLR −/− mice were fed with a high-fat diet and treated with 50 µg BPA/kg body weight by gavage. After two months of treatment, the area of atherosclerotic lesions in the aorta, triglycerides and total cholesterol levels were significantly increased, while HDL-cholesterol was decreased in BPA-treated LDLR −/− mice as compared to control mice. Real-Time PCR data showed that BPA treatment decreased hepatic apoA-I expression. BPA downregulated the activity of the apoA-I promoter in a dose-dependent manner. This inhibitory effect was mediated by MEKK1/NF-κB signaling pathways. Transfection experiments using apoA-I promoter deletion mutants, chromatin immunoprecipitation, and protein-DNA interaction assays demonstrated that treatment of hepatocytes with BPA induced NF-κB signaling and thus the recruitment of p65/50 proteins to the multiple NF-κB binding sites located in the apoA-I promoter. In conclusion, BPA exerts pro-atherogenic effects downregulating apoA-I by MEKK1 signaling and NF-κB activation in hepatocytes. Int. J. Mol. Sci. 2019, 20, 6281 2 of 15 and in apoA-I −/− /LDLR −/− mice [6]. On the other hand, overexpression of human apoA-I reduced atherogenesis in apoE −/− or in LDLR −/− mice [7][8][9][10][11][12][13][14], providing strong evidence for the antiatherogenic role of apoA-I. Recently, it was proposed that the ratio of HDL-cholesterol to apoA-I gives additional insights as a risk marker for cardiovascular disease [15]. To exploit the anti-atherogenic properties of HDL-apoA-I, different approaches, such as pharmacological interventions using HDL-apoA-I mimetic peptides or infusions of apoA-I-containing particles were proposed for the reduction of atherogenesis [16,17].In humans, the APOAI gene is 1.8 Kb in length and it is located on chromosome 11 in the APOAI/APOCIII/APOAIV gene cluster [18]. ApoA-I is synthesized mainly by the liver and the small intestine. APOAI gene expression is mainly regulated at transcriptional level [19]. The APOAI gene promoter contains a TATA box and several cis elements that regulate its gene expression in either a positive or negative manner. Acidosis caused apoA-I downregulation by promoting binding of repressor proteins to a pH-responsive element that overlaps the TATA box within the apoA-I promoter [20]. Several hormones, such as glucocorticoids, thyroid hormones, and insulin, induced APOAI gene expression through a direct mechanism interacting with their specific hormone response elements [21,22]. In humans, treatment with fibrates that interact with a PPAR-responsive element located in the apoA-I promoter increased APOAI gene expression, but opposite effects of fibrates on apoA-I expression were found in r...

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Bisphenol A (BPA) the mighty and the mutagenic

Abstract: Graphical abstract

Cited by 208 publications

References 92 publications

Neurochemical characterization of the enteric neurons within the porcine jejunum in physiological conditions and under the influence of bisphenol A (BPA)

Neurochemical characterization of the enteric neurons within the porcine jejunum in physiological conditions and under the influence of bisphenol A (BPA)

Packaging perspective of milk and dairy products

The Mechanism of Bisphenol A Atherogenicity Involves Apolipoprotein A-I Downregulation through NF-κB Activation

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