Bisphenol A and phthalate levels in adolescents with polycystic ovary syndrome

Akgül, Sinem; Sur, Ünzile; Düzçeker, Yasemin; Balcı, Aylin; Kızılkan, Melis Pehlivantürk; Kanbur, Nuray; Bozdağ, Gürkan; Erkekoğlu, Pınar; Gümüş, Ersin; Koçer-Gümüşel, Belma; Derman, Orhan

doi:10.1080/09513590.2019.1630608

Cited by 48 publications

(33 citation statements)

References 25 publications

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“…A study in 2019 focusing on adolescents looked at BPA levels in 62 girls with PCOS and 33 control subjects in the age range, 12–18 years. 180 High-performance liquid chromatography was employed to measure urinary BPA concentrations. The adolescent patients demonstrated markedly greater BPA levels (case: 15.89 μg/g versus control: 7.30 μg/g creatinine).…”

Section: Etiology Of Pcosmentioning

confidence: 99%

An update on polycystic ovary syndrome: A review of the current state of knowledge in diagnosis, genetic etiology, and emerging treatment options

Islam

Masud

Islam

et al. 2022

Womens Health (Lond Engl)

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Polycystic ovary syndrome is the most common endocrine disorder in women of reproductive age, which is still incurable. However, the symptoms can be successfully managed with proper medication and lifestyle interventions. Despite its prevalence, little is known about its etiology. In this review article, the up-to-date diagnostic features and parameters recommended on the grounds of evidence-based data and different guidelines are explored. The ambiguity and insufficiency of data when diagnosing adolescent women have been put under special focus. We look at some of the most recent research done to establish relationships between different gene polymorphisms with polycystic ovary syndrome in various populations along with the underestimated impact of environmental factors like endocrine-disrupting chemicals on the reproductive health of these women. Furthermore, the article concludes with existing treatments options and the scopes for advancement in the near future. Various therapies have been considered as potential treatment through multiple randomized controlled studies, and clinical trials conducted over the years are described in this article. Standard therapies ranging from metformin to newly found alternatives based on vitamin D and gut microbiota could shine some light and guidance toward a permanent cure for this female reproductive health issue in the future.

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Section: Etiology Of Pcosmentioning

confidence: 99%

An update on polycystic ovary syndrome: A review of the current state of knowledge in diagnosis, genetic etiology, and emerging treatment options

Islam

Masud

Islam

et al. 2022

Womens Health (Lond Engl)

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“…A wide-array of EDCs, including BPA and phthalates, are known to possess androgenic activities, and NHANES studies indicate that the majority of humans (greater than 95%) possess detectable serum and urinary levels of these agents [38,39]. Furthermore, a recent study showed that the levels of BPA and phthalates were significantly elevated in adolescent girls with PCOS [47]. Furthermore, BPA is thought to increase androgen levels in females by inhibiting aromatase activity in ovarian granulosa cells [48].…”

Section: Androgensmentioning

confidence: 99%

Endocrine Disrupting Chemicals, Hormone Receptors, and Acne Vulgaris: A Connecting Hypothesis

Rao

Douglas

Hall

2021

Cells

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The relationship between endocrine disrupting chemicals (EDCs) and the pathogenesis of acne vulgaris has yet to be explored in the literature. Acne vulgaris is a chronic inflammatory skin disease of the pilosebaceous unit. The pathogenesis of acne involves several hormonal pathways, including androgens, insulin-like growth factor 1(IGF-1), estrogens, and corticosteroids. EDCs influence these pathways primarily through two mechanisms: altering endogenous hormone levels and interfering with hormone receptor function. This review article describes the mechanistic links between EDCs and the development of acne lesions. Highlighted is the contributory role of androgen receptor ligands, such as bisphenol A (BPA) and mono-2-ethylhexyl Phthalate (MEHP), via upregulation of lipogenic genes and resultant exacerbation of cholesterol synthesis. Additionally discussed is the protective role of phytoestrogen EDCs in counteracting androgen-induced sebocyte maturation through attenuation of PPARy transcriptional activity (i.e., resveratrol) and restoration of estrogen-regulated TGF-B expression in skin cells (i.e., genistein). Examination of the relationship between EDCs and acne vulgaris may inform adjunctive avenues of treatment such as limiting environmental exposures, and increasing low-glycemic, plant-rich foods in the diet. With a better understanding of the cumulative role that EDCs play in acne, clinicians can be better equipped to treat and ultimately improve the lives of their patients.

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“… 69 Adolescents with polycystic ovary syndrome were found to have significantly higher BPA levels when compared with the control group. 70 …”

Section: Resultsmentioning

confidence: 99%

New insights on the effects of endocrine-disrupting chemicals on children

Predieri

Alves

2022

Jornal de Pediatria

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Bisphenol A and phthalate levels in adolescents with polycystic ovary syndrome

Cited by 48 publications

References 25 publications

An update on polycystic ovary syndrome: A review of the current state of knowledge in diagnosis, genetic etiology, and emerging treatment options

An update on polycystic ovary syndrome: A review of the current state of knowledge in diagnosis, genetic etiology, and emerging treatment options

Endocrine Disrupting Chemicals, Hormone Receptors, and Acne Vulgaris: A Connecting Hypothesis

New insights on the effects of endocrine-disrupting chemicals on children

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